The impact of attention on social functioning in survivors of pediatric acute lymphoblastic leukemia and brain tumors

Moyer, Katherine H.; Willard, Victoria W.; Gross, Alan M.; Netson, Kelli L.; Ashford, Jason M.; Kahalley, Lisa S.; Wu, Shengjie; Xu, Xiaoping; Conklin, Heather M.

doi:10.1002/pbc.24256

Cited by 60 publications

(54 citation statements)

References 46 publications

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“…Our findings also support the association between cognition and social outcomes in recent studies (Moyer et al, 2012; Poggi et al, 2005). However, to our knowledge, no social competence interventions have included a cognitive rehabilitation component.…”

Section: Discussionsupporting

confidence: 92%

“She Was a Little Social Butterfly”: A Qualitative Analysis of Parent Perception of Social Functioning in Adolescent and Young Adult Brain Tumor Survivors

Wilford

Buchbinder

Fortier

et al. 2017

J Pediatr Oncol Nurs

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Psychosocial sequelae of diagnosis and treatment for childhood brain tumor survivors are significant, yet little is known about their impact on adolescent and young adult (AYA) brain tumor survivors. Interviews were conducted with parents of AYA brain tumor survivors with a focus on social functioning. Semistructured interviews were conducted with English- and Spanish-speaking parents of AYA brain tumor survivors ≥10 years of age who were >2 years postdiagnosis, and analyzed using emergent themes theoretically integrated with a social neuroscience model of social competence. Twenty parents representing 19 survivors with a survivor mean age 15.7 ± 3.3 years and 10.1 ± 4.8 years postdiagnosis were interviewed. Several themes relevant to the social neuroscience social competence model emerged. First, parents’ perceptions of their children’s impaired social functioning corroborated the model, particularly with regard to poor social adjustment, social withdrawal, impaired social information processing, and developmentally inappropriate peer communication. Second, ongoing physical and emotional sequelae of central nervous system insults were seen by parents as adversely affecting social functioning among survivors. Third, a disrupted family environment and ongoing parent psychosocial distress were experienced as salient features of daily life. We document that the aforementioned framework is useful for understanding the social impact of diagnosis and treatment on AYA brain tumor survivorship. Moreover, the framework highlights areas of intervention that may enhance social functioning for AYA brain tumor survivors.

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Section: Discussionsupporting

confidence: 92%

“She Was a Little Social Butterfly”: A Qualitative Analysis of Parent Perception of Social Functioning in Adolescent and Young Adult Brain Tumor Survivors

Wilford

Buchbinder

Fortier

et al. 2017

J Pediatr Oncol Nurs

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“…Survivors of ALL and BT are known to be at risk for attention difficulties (Brouwers et al, 1984; Buizer et al, 2005; Butler et al, 2013; Langer et al, 2002; Moyer et al, 2012; Reddick et al, 2006). Our findings suggest that attention is the primary deficit in affected survivors of ALL, while attentional difficulties appear to be part of a more global deficit profile in affected survivors of BT.…”

Section: Discussionmentioning

confidence: 99%

Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia

Winter

Conklin

Tyc

et al. 2014

Journal of Clinical and Experimental Neuropsychology

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BACKGROUND Survivors of pediatric brain tumors (BT) and acute lymphoblastic leukemia (ALL) are at risk for neurocognitive late effects related to executive function. PROCEDURE Survivors of BT (48) and ALL (50) completed neurocognitive assessment. Executive function was compared to estimated IQ and population norms by diagnostic group. RESULTS Both BT and ALL demonstrated relative executive function weaknesses. As a group, BT survivors demonstrated weaker executive functioning than expected for age. Those BT survivors with deficits exhibited a profile suggestive of global executive dysfunction, while affected ALL survivors tended to demonstrate specific rapid naming deficits. CONCLUSION Findings suggest that pediatric BT and ALL survivors may exhibit different profiles of executive function late effects, which may necessitate distinct intervention plans.

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“…However, intrathecal methotrexate is associated with neurotoxic sequelae including cognitive deficits. Survivors of childhood leukemia show an increased rate of deficits in working memory and executive function, leading to impaired school and occupational performance (1–7), as well as diminished quality of life (8–10). Among patients treated without cranial radiation, treatment intensity explains some portion of the variability in cognitive outcomes (5), but all children with ALL seem to be at some risk of posttreatment cognitive dysfunction (11).…”

Section: Introductionmentioning

confidence: 99%

Memantine Protects Rats Treated with Intrathecal Methotrexate from Developing Spatial Memory Deficits

Cole

Vijayanathan

Ali

et al. 2013

Clinical Cancer Research

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Purpose To test whether memantine can prevent methotrexate-induced cognitive deficits in a preclinical model. Experimental Design After noting that methotrexate exposure induces prolonged elevations of the glutamate analog homocysteic acid (HCA) within cerebrospinal fluid, we tested whether intrathecal injection of HCA would produce memory deficits similar to those observed after intrathecal methotrexate. We then tested whether memantine, an antagonist of the N-methyl-D-aspartate (NMDA) subclass of glutamate receptors, could protect animals treated with clinically relevant doses of intrathecal methotrexate against developing memory deficits. Finally, we asked whether memantine affected this pathway beyond inhibiting the NMDA receptor by altering expression of the NMDA receptor or affecting concentrations of HCA or glutamate within the central nervous system. Results Four intrathecal doses of methotrexate induced deficits in spatial memory, persisting at least one month following the final injection. Intrathecal HCA was sufficient to reproduce this deficit. Concurrent administration of memantine during the period of methotrexate exposure was protective, decreasing the incidence of methotrexate-induced spatial memory deficits from 56% to 20% (P < 0.05). Memantine neither altered expression of NMDA receptors within the hippocampus nor blunted the methotrexate-induced increases in glutamate or HCA. Conclusions Excitotoxic glutamate analogs including HCA contribute to cognitive deficits observed after intrathecal methotrexate. Memantine, an NMDA receptor antagonist, reduces the incidence of cognitive deficits in rats treated with intrathecal methotrexate, and may therefore benefit patients with cancer receiving similar treatment.

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The impact of attention on social functioning in survivors of pediatric acute lymphoblastic leukemia and brain tumors

Cited by 60 publications

References 46 publications

“She Was a Little Social Butterfly”: A Qualitative Analysis of Parent Perception of Social Functioning in Adolescent and Young Adult Brain Tumor Survivors

“She Was a Little Social Butterfly”: A Qualitative Analysis of Parent Perception of Social Functioning in Adolescent and Young Adult Brain Tumor Survivors

Executive function late effects in survivors of pediatric brain tumors and acute lymphoblastic leukemia

Memantine Protects Rats Treated with Intrathecal Methotrexate from Developing Spatial Memory Deficits

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