The impact of atosiban on pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer: A meta-analysis

Abstract

BackgroundAtosiban is administered to women undergoing in vitro fertilization-embryo transfer (IVF-ET) to improve pregnancy outcomes. However, the results of this treatment were controversial. We conducted this meta-analysis to investigate whether atosiban improves pregnancy outcomes in the women undergoing in vitro fertilization (IVF).MethodsDatabases of PubMed, EMBASE, Web of Science, China BioMedicine, and Google Scholar were systematically searched. Meta-analyses were performed to investigate whether atosiban improves pregnancy outcomes in the women undergoing IVF.ResultsOur results showed that atosiban was associated with higher implantation (OR = 1.63, 95% CI: 1.17–2.27; P = 0.004) and clinical pregnancy (OR = 1.84, 95% CI: 1.31–2.57; P < 0.001) rates. However, atosiban showed no significant association with the miscarriage, live birth, multiple pregnancy or ectopic pregnancy rates. When a further subgroup analysis was performed in the women undergoing repeated implantation failure (RIF), implantation (OR = 1.93, 95% CI: 1.45–2.57; P < 0.001), clinical pregnancy (OR = 2.48, 95% CI: 1.70–3.64; P <0.001) and the live birth (OR = 2.89, 95% CI: 1.78–4.67; P < 0.001) rates were significantly higher in the case group. Nevertheless, no significant difference was detected in the miscarriage and multiple pregnancy rates between the case and control groups.ConclusionAtosiban may be more appropriate for women undergoing RIF and play only a limited role in improving pregnancy outcomes in the general population of women undergoing IVF. These conclusions should be verified in large and well-designed studies.

Impairment of Uterine Contractility Is Associated with Unexplained Infertility

“…9, 95% CI: 1.8-4.7). 84 In addition to conflicting results regarding benefit in either a general or specific infertility population, Atosiban has the disadvantage of being an intravenously administered therapeutic.…”

Effect of sex hormone–binding globulin polymorphisms on the outcome of in vitro fertilization‐embryo transfer for polycystic ovary syndrome patients: A case‐control study

“…In recent years, in vitro fertilization‐embryo transfer (IVF‐ET), an accessorial reproduction technology that extracts oocytes from infertile women for fertilization in vitro, has been regarded as one of the most effective therapies for PCOS . Huang et al have explored the effect of body mass index (BMI) on the results of IVF treatment of PCOS patients in China, finding that in comparison with obese women, PCOS women with a BMI of ≥24 kg/m 2 had poorer clinical pregnancy rates.…”

Efficacy of therapies and interventions for repeated embryo implantation failure: a systematic review and meta-analysis

“…After a review of the titles and abstracts, 154 studies were identified as potentially eligible for inclusion. After a full review, we excluded 19 systematic reviews or meta-analysis 2,5,22,23,37,[46][47][48][49][50][51][52][53][54][55][56][57][58][59] , 8 case reports [60][61][62][63][64][65][66][67] , 4 letters to the editor [68][69][70][71] and 81 original studies [references and reasons for exclusion are reported in Table 1]. Data on the efficacy of therapies and interventions for RIF were extracted from the remaining 42 articles 8,12,13,18,20,21,24,27,28,31,75, .…”