The impact of antimicrobial use in broiler chickens on growth performance and on the occurrence of antimicrobial-resistant Escherichia coli

Costa, Paulo Martins da; Oliveira, Manuela; Ramos, Bruno; Bernardo, Fernando

doi:10.1016/j.livsci.2010.09.016

Cited by 23 publications

(7 citation statements)

References 23 publications

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“…While we did observe the production signature for AR in the immediate production environment, this signature production pattern of AR did not occur in the domestic environment, suggesting that AR selected for by poultry production systems is limited to the production environment. It is possible that the frequency of sampling and the culturing methods that we used did not offer enough power to detect the effect of added systemic antibiotics that other studies have reported ( 24 , 30 , 36 , 37 ). However, it is also possible that the intermittent nature of intensive production does not result in sufficient pressure to affect bacterial populations within the household environment.…”

Section: Discussionmentioning

confidence: 94%

Antibiotic Resistance in Animal and Environmental Samples Associated with Small-Scale Poultry Farming in Northwestern Ecuador

Braykov

Eisenberg

Grossman

et al. 2016

mSphere

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In developing countries, small-scale poultry farming employing antibiotics as growth promoters is being advanced as an inexpensive source of protein and income. Here, we present the results of a large ecoepidemiological study examining patterns of antibiotic resistance (AR) in E. coli isolates from small-scale poultry production environments versus domestic environments in rural Ecuador, where such backyard poultry operations have become established over the past decade. Our previous research in the region suggests that introduction of AR bacteria through travel and commerce may be an important source of AR in villages of this region. This report extends the prior analysis by examining small-scale production chicken farming as a potential source of resistant strains. Our results suggest that AR strains associated with poultry production likely originate from sources outside the study area and that these outside sources might be a better place to target control efforts than local management practices.

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Section: Discussionmentioning

confidence: 94%

Antibiotic Resistance in Animal and Environmental Samples Associated with Small-Scale Poultry Farming in Northwestern Ecuador

Braykov

Eisenberg

Grossman

et al. 2016

mSphere

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“…These transferable plasmids carry mobile genetic DNA elements (integrons) that often contain numerous genes for resistance to antibiotics, which are transferred simultaneously to other bacteria, where they are jointly expressed (Schroeder, Hoog, & Helmuth, ). According to Martins da Costa, Oliveira, Ramos, and Bernardo (), the phenomenon of coselection is hugely important in the persistence of multiresistant strains which are, moreover, stable and capable of lingering on farms long after any selective pressures have disappeared (Song et al, ).…”

Section: Discussionmentioning

confidence: 99%

Microbial load and antibiotic resistance in raw beef preparations from northwest Spain

González-Gutiérrez

García‐Fernández

Alonso‐Calleja

et al. 2019

Food Science & Nutrition

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Beef preparations (meatballs, minced meat, hamburgers, white sausages, and red sausages) from northwest Spain were tested. Microbial counts ranged from 0.70 ± 0.00 log10 cfu/g (enterococci) to 9.57 ± 0.37 log10 cfu/g (psychrotrophs). In 73.3% of cases, total aerobic counts were higher than the microbiological limits set for the end of the manufacturing process in the European Union (EU Regulation 2073/2005). Forty Escherichia coli isolates were tested against thirteen clinically important antibiotics (disk diffusion method; CLSI). Three of the strains (7.5%) were susceptible to all the antibiotics, four (10.0%) showed resistance or reduced susceptibility to one antibiotic, and 33 (82.5%) were multiresistant (with resistance or reduced susceptibility to between two and eight antibiotics), with an average of 1.85 resistances per strain. The highest rates of resistance were observed for two antimicrobials widely used on cattle farms (cefalotin and tetracycline). The findings in this research emphasize the need to correctly handle beef preparations with the aim of reducing risks to consumers.

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“…Apramycin MIC90 dropped to a relatively low level 3 days after cessation, but increased again from Days 20 to 40 after cessation. Some studies have investigated the influence of other antibiotics on resistance changes of E. coli isolated from different farm animals ( Smith et al, 2007 ; Martins da Costa et al, 2011 ; Sato et al, 2014 ). These previous studies have also demonstrated that antimicrobials caused selective pressure and resulted in increased resistance to bacteria originating from animals.…”

Section: Discussionmentioning

confidence: 99%

“…This change in antibiotic resistance has also been observed in other studies featuring no antimicrobial treatment ( Diarra et al, 2007 ; da Costa et al, 2009 ). These findings might be due to the influence of resistant strains in the farm environment and animal feed on microbial composition in the chicken gut ( Apajalahti et al, 2004 ; Martins da Costa et al, 2011 ). We also hypothesized that the change of resistant phenotype of the un-medicated group was due to the spread of the resistant strains from the medicated group to un-medicated group through environmental factors (e.g., air, dust, mice, and flies).…”

Section: Discussionmentioning

confidence: 99%

“…Antimicrobial resistance emerges from the use of antimicrobials in animals and the subsequent transfer of resistance bacteria from those animals to the broader environment ( Berendonk et al, 2015 ). The influence of antimicrobial usage on the prevalence of resistant strains in animals is of great concern for wider public health ( da Costa et al, 2008 ; Martins da Costa et al, 2011 ; Sato et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Resistance Patterns and Detection of Apramycin Resistance Genes in Escherichia coli Isolated from Chicken Feces and Houseflies after Apramycin Administration

Zhang

Guan

et al. 2018

Front. Microbiol.

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The aim of this study was to evaluate the influence of apramycin administration on the development of antibiotic resistance in Escherichia coli (E. coli) strains isolated from chicken feces and houseflies under field conditions. Chickens in the medicated group (n = 25,000) were given successive prophylactic doses (0.5 mg/l) of apramycin in their drinking water from Days 1 to 5, while no antibiotics were added to the un-medicated groups drinking water (n = 25,000). Over 40 days, a total of 1170 E. coli strains were isolated from fecal samples obtained from medicated and un-medicated chickens and houseflies from the same chicken farm. Apramycin MIC90 values for E. coli strains obtained from the medicated group increased 32–128 times from Days 2 to 6 (256–1024 μg/ml) when compared to those on Day 0 (8 μg/ml). Strains isolated from un-medicated chickens and houseflies had consistently low MIC90 values (8–16 μg/ml) during the first week, but showed a dramatic increase from Days 8 to 10 (128–1024 μg/ml). The apramycin resistance gene aac(3)-IV was detected in E. coli strains from medicated (n = 71), un-medicated (n = 32), and housefly groups (n = 42). All strains positive for aac(3)-IV were classified into 12 pulsed-field gel electrophoresis (PFGE) types. PFGE types A, E, and G were the predominant types in both the medicated and housefly groups, suggesting houseflies play an important role in spreading E. coli-resistant strains. Taken together, our study revealed that apramycin administration could facilitate the occurrence of apramycin-resistant E. coli and the apramycin resistance gene acc(3)-IV. In turn, these strains could be transmitted by houseflies, thus increasing the potential risk of spreading multi-drug-resistant E. coli to the public.

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The impact of antimicrobial use in broiler chickens on growth performance and on the occurrence of antimicrobial-resistant Escherichia coli

Cited by 23 publications

References 23 publications

Antibiotic Resistance in Animal and Environmental Samples Associated with Small-Scale Poultry Farming in Northwestern Ecuador

Antibiotic Resistance in Animal and Environmental Samples Associated with Small-Scale Poultry Farming in Northwestern Ecuador

Microbial load and antibiotic resistance in raw beef preparations from northwest Spain

Characterization of Resistance Patterns and Detection of Apramycin Resistance Genes in Escherichia coli Isolated from Chicken Feces and Houseflies after Apramycin Administration

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