The impact of an enhanced health surveillance system for COVID-19 management in Serrana, Brazil

Ferreira, Nilson; Garibaldi, Pedro Manoel Marques; Moraes, Glenda R.; Moura, José Carlos de; Klein, Taline Monteiro; Machado, Larissa E.; Scofoni, Lilian F.B.; Haddad, Simone Kashima; Calado, Rodrigo T.; Covas, Dimas Tadeu; Fonseca, Benedito Antônio Lopes da; Palácios, Ricardo; Conde, Monica T.R.P.; Borges, Marcos C.

doi:10.1016/j.puhip.2022.100301

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…Further, under the Butantan Institute’s guidance, Serrana participated in the first stepped-wedge trial to assess the efficiency of the CoronaVac vaccine. Briefly, this clinical trial was conducted between the epidemiological weeks 6 and 19 of 2021, coinciding with the mid-Gamma VOC wave of the second wave when the Gamma VOC was introduced and became predominant (for more information of the campaign organization, refer to reference [ 20 ]). Additionally, by this time São Paulo state had established the Network for Pandemic Alert of SARS-CoV-2 variants, that improved the genomic surveillance in this region and helped to understand the introduction routes of the SARS-CoV-2 variants in the town of Serrana.…”

Section: Discussionmentioning

confidence: 99%

Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil

Slavov

La-Roque²,

Costa³

et al. 2022

Viruses

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From a country with one of the highest SARS-CoV-2 morbidity and mortality rates, Brazil has implemented one of the most successful vaccination programs. Brazil’s first model city vaccination program was performed by the CoronaVac vaccine (Sinovac Biotech) in the town of Serrana, São Paulo State. To evaluate the vaccination effect on the SARS-CoV-2 molecular dynamics and clinical outcomes, we performed SARS-CoV-2 molecular surveillance on 4375 complete genomes obtained between June 2020 and April 2022 in this location. This study included the period between the initial SARS-CoV-2 introduction and during the vaccination process. We observed that the SARS-CoV-2 substitution dynamics in Serrana followed the viral molecular epidemiology in Brazil, including the initial identification of the ancestral lineages (B.1.1.28 and B.1.1.33) and epidemic waves of variants of concern (VOC) including the Gamma, Delta, and, more recently, Omicron. Most probably, as a result of the immunization campaign, the mortality during the Gamma and Delta VOC was significantly reduced compared to the rest of Brazil, which was also related to lower morbidity. Our phylogenetic analysis revealed the evolutionary history of the SARS-CoV-2 in this location and showed that multiple introduction events have occurred over time. The evaluation of the COVID-19 clinical outcome revealed that most cases were mild (88.9%, 98.1%, 99.1% to Gamma, Delta, and Omicron, respectively) regardless of the infecting VOC. In conclusion, we observed that vaccination was responsible for reducing the death toll rate and related COVID-19 morbidity, especially during the gamma and Delta VOC; however, it does not prevent the rapid substitution rate and morbidity of the Omicron VOC.

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Section: Discussionmentioning

confidence: 99%

Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil

Slavov

La-Roque²,

Costa³

et al. 2022

Viruses

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Antibody response dynamics to CoronaVac vaccine and booster immunization in adults and the elderly: A long-term, longitudinal prospective study

Volpe¹,

Vessoni

Soares

et al. 2023

IJID Regions

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Inspeções Sanitárias Em Consórcios De Saúde Na Covid-19

Reginaldo Pinto,

Dos Santos de Sousa,

Saraiva Silveira Araújo

et al. 2023

Cadernos ESP

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O estudo objetivou verificar as conformidades e não conformidades sanitárias existentes nos serviços consorciados de saúde durante a pandemia de Covid-19. Pesquisa de análise documental, abrangeu a macrorregião de saúde de Sobral, Ceará. Essa macrorregião possui cinco regiões de saúde, sendo que cada uma possui uma policlínica e um centro de especialidade odontológica regional. Utilizou-se os relatórios de inspeção sanitária produzidos pelos inspetores estaduais que continham informações sobre estrutura, organização e funcionamento dessas unidades, avaliadas de setembro de 2020 a setembro de 2021. Os resultados foram georreferenciados pelo software Quantum GIS 3.26, Buenos Aires. Verificou-se que a policlínica de Sobral estava em melhor conformidade sanitária, enquanto Acaraú necessitava de ajustes nos processos de trabalho, segurança dos pacientes e segurança ocupacional. Quanto aos CEOs avaliados, dois apresentaram excelentes conformidades sanitárias e três estavam com itens em não conformidade. Essas evidências sugerem a melhoria da gestão da qualidade nos consórcios de saúde avaliados.

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The impact of an enhanced health surveillance system for COVID-19 management in Serrana, Brazil

Cited by 3 publications

References 33 publications

Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil

Dynamics of SARS-CoV-2 Variants of Concern in Vaccination Model City in the State of Sao Paulo, Brazil

Antibody response dynamics to CoronaVac vaccine and booster immunization in adults and the elderly: A long-term, longitudinal prospective study

Inspeções Sanitárias Em Consórcios De Saúde Na Covid-19

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