The impact of amalgam dental fillings on the frequency of Helicobacter pylori infection and H. pylori eradication rates in patients treated with concomitant, quadruple, and levofloxacin-based therapies

Aktaş, Bora; Başyiğit, Sebahat; Yüksel, Osman; Akkan, Tolga; Atbaşı, Suna Tülin; Uzman, Metin; Yılmaz, Barış; Şimşek, Gülçin Güler; Nazlıgül, Yaşar

doi:10.1097/meg.0000000000000372

Cited by 4 publications

(2 citation statements)

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“…Epidemiological studies have indicated that the prevalence of Helicobacter pylori ( H. pylori ) infection has an incidence of 20–50% in developed countries and 40–60% in China 1 , 2 . H. pylori plays a causative role in many diseases, including gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma and gastric cancer 3 – 8 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy of two different dosages of levofloxacin in curing Helicobacter pylori infection: A Prospective, Single-Center, randomized clinical trial

Gan

Tie-li

Huang

et al. 2018

Sci Rep

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Bismuth + proton pump inhibitor (PPI) + amoxicillin + levofloxacin is one of the bismuth quadruple therapy regimens widely used for the eradication of H. pylori infection. The recommended dosage of levofloxacin is 500 mg once daily or 200 mg twice daily to eradicate H. pylori infection. The aim of the present open-label, randomized control trial was to compare the effectiveness, safety, and compliance of different dosages of levofloxacin used to cure Helicobacter pylori infection. Eligible patients were randomly assigned to receive esomeprazole, amoxicillin, colloidal bismuth pectin and levofloxacin 500 mg once/day (group A) or levofloxacin 200 mg twice/day (group B) for 14 days. The primary outcome was the eradication rates in the intention-to-treat (ITT) and per protocol (PP) analyses. Overall, 400 patients were enrolled. The eradication rates in group A and group B were 77.5% and 79.5% respectively, in the ITT analysis, and 82.9% and 86.4%, respectively, in the PP analysis. No significant differences were found between two groups in terms of eradication rate, adverse effects or compliance. Oral levofloxacin 200 mg twice daily was similar in efficacy for eradicating H. pylori infection to oral levofloxacin 500 mg once daily but with lower mean total costs.

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Section: Introductionmentioning

confidence: 99%

Efficacy of two different dosages of levofloxacin in curing Helicobacter pylori infection: A Prospective, Single-Center, randomized clinical trial

Gan

Tie-li

Huang

et al. 2018

Sci Rep

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“…elicobacter pylori is a common infectious agent worldwide with a prevalence of 20-50% in developed countries and 80% in developing countries [1]. This gram-negative and microaerophilic bacterium colonizes the gastric mucosa and duodenum and causes chronic gastritis as well as diseases such as gastric adenocarcinoma, MALT lymphoma, gastric & duodenal ulcers [2][3][4].…”

mentioning

confidence: 99%

Prevalence of Helicobacter Pylori in the Tonsil and Adenoid Tissue of Adenotonsillectomy Patients with Rapid Urease Test

Yousefi

Shoghi

Taheri

et al. 2020

hrjbaq

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Introduction: Helicobacter pylori is a micro-aerophilic gram-negative bacteria that is colonized in the gastric mucosa and duodenum using its own factors such as urease, catalase and lipase. While the stomach is considered the main source of it, other tissues such as the Walder ring, gallbladder, gums, oral lesions and dental plaque have also been suggested as potential sources. Recent studies suggest that adenotonsillar tissue is susceptible to Helicobacter pylori colonization, but the results are very contradictory. Therefore, in the present study, we tried to evaluate the presence of this bacterium in this tissue. Materials and Methods: In this cross-sectional study, which was conducted from October 2017 to October 2016, cases of adenotonsillectomy surgery without a history of antibiotics and bismuth in the last two weeks were included in the study. 2 to 5 mm of samples were removed and placed in a filled vial up to half of the urease test kit solution. Change of color of the solution from yellow to purple was a positive result and no color change after a maximum of one hour, a negative result was recorded. Results: A total of 114 samples were obtained from 64 patients, of which 63 were tonsil samples and 51 were adenoids. In 5 samples (all tissues removed from the tonsil), the urease test was positive (4.4%) and the other 109 samples (95.6%) were negative. There was no significant relationship between urease test result with tissue type (P = 0.063), reason for surgery (P = 0.65) and age (P = 0.07). Conclusion: Our results showed that Helicobacter pylori colonization in adenotonsillar tissue had a frequency of 4.4%, in other words, 5 out of 64 patients (7.8%) had tonsil colonization with Helicobacter pylori, which showed a small amount.

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Annual review of selected scientific literature: Report of the committee on scientific investigation of the American Academy of Restorative Dentistry

Donovan

Marzola²,

Murphy³

et al. 2016

The Journal of Prosthetic Dentistry

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The impact of amalgam dental fillings on the frequency of Helicobacter pylori infection and H. pylori eradication rates in patients treated with concomitant, quadruple, and levofloxacin-based therapies

Abstract: This is the first study to show a lower frequency of H. pylori colonization in patients with amalgam fillings than without and that H. pylori eradication rates are lower in patients with amalgam fillings compared to those without.

Cited by 4 publications

References 40 publications

Efficacy of two different dosages of levofloxacin in curing Helicobacter pylori infection: A Prospective, Single-Center, randomized clinical trial

Efficacy of two different dosages of levofloxacin in curing Helicobacter pylori infection: A Prospective, Single-Center, randomized clinical trial

Prevalence of Helicobacter Pylori in the Tonsil and Adenoid Tissue of Adenotonsillectomy Patients with Rapid Urease Test

Annual review of selected scientific literature: Report of the committee on scientific investigation of the American Academy of Restorative Dentistry

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