The impact of Akkermansia muciniphila and its extracellular vesicles in the regulation of serotonergic gene expression in a small intestine of mice

Yaghoubfar, Rezvan; Zare BanadKoki, Ehsan; Ashrafian, Fatemeh; Shahryari, Arefeh; Kariman, Arian; Davari, Mehdi; Fateh, Abolfazl; Khatami, Shohreh; Siadat, Seyed Davar

doi:10.1016/j.anaerobe.2023.102786

Cited by 1 publication

(1 citation statement)

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“…Certain gut bacteria, such as Lactobacillus, Lactococcus, Streptococcus, and Klebsiella, increase the gene expression of tryptophan synthetase, leading to the augmented production of serotonin [71]. Furthermore, studies have reported that Akkermansia muciniphila and its extracellular vesicles affected the mRNA expression of genes involved in serotonin signaling/metabolism in the hippocampus and the colon through the GBA [73][74][75][76].…”

Section: Kynurenine Pathway Metabolites and Neurotransmittersmentioning

confidence: 99%

The Power of Psychobiotics in Depression: A Modern Approach through the Microbiota–Gut–Brain Axis: A Literature Review

Dziedzic,

Maciak,

Bliźniewska-Kowalska

et al. 2024

Nutrients

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The microbiota–gut–brain (MGB) axis is a complex communication network linking the gut, microbiota, and brain, influencing various aspects of health and disease. Dysbiosis, a disturbance in the gut microbiome equilibrium, can significantly impact the MGB axis, leading to alterations in microbial composition and function. Emerging evidence highlights the connection between microbiota alterations and neurological and psychiatric disorders, including depression. This review explores the potential of psychobiotics in managing depressive disorders, emphasizing their role in restoring microbial balance and influencing the MGB axis. Psychobiotics exhibit positive effects on the intestinal barrier, immune response, cortisol levels, and the hypothalamic–pituitary–adrenal (HPA) axis. Studies suggest that probiotics may serve as an adjunct therapy for depression, especially in treatment-resistant cases. This review discusses key findings from studies on psychobiotics interventions, emphasizing their impact on the gut–brain axis and mental health. The increasing acceptance of the expanded concept of the MGB axis underscores the importance of microorganisms in mental well-being. As our understanding of the microbiome’s role in health and disease grows, probiotics emerge as promising agents for addressing mental health issues, providing new avenues for therapeutic interventions in depressive disorders.

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