The Impact of Aging on Cardio and Cerebrovascular Diseases

Izzo, Carmine; Carrizzo, Albino; Alfano, Antonia; Virtuoso, Nicola; Coccia, Mario; Calabrese, Mariaconsiglia; Simone, Eros De; Sciarretta, Sebastiano; Frati, Giacomo; Oliveti, Marco; Damato, Antonio L.; Ambrosio, Mariateresa; De, Francesco; Remondelli, Paolo; Vecchione, Carmine

doi:10.3390/ijms19020481

Cited by 76 publications

(66 citation statements)

References 257 publications

(280 reference statements)

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“…Those changes were particularly apparent in males ( Supplementary Table S2). Previous studies have found that CO does not change, whereas SV increases with aging in humans [12,25].…”

Section: Discussionmentioning

confidence: 79%

Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range

et al. 2020

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Various cardiovascular diseases can be detected and diagnosed using echocardiography. The demand for cardiovascular system research using nonhuman primates is increasing, but echocardiographic references for nonhuman primates are limited. This report describes the first comparison of echocardiographic reference values in 247 normal cynomolgus monkeys (135 females, 112 males) over a wide age range. Echocardiography, electrocardiography, blood pressure and chest X-ray images were acquired under immobilization with intramuscular ketamine hydrochloride, then cardiac structure, function, and flow velocity were assessed. Cardiac hormone levels were also tested. We found that cardiac structures positively correlated with weight, that the size of these structures stabilized after reaching maturity and that cardiac output increased according to heart size. In contrast, fractional shortening of the left ventricle, ejection fraction and flow velocity showed no significant correlations with weight or age, and age and E wave correlated negatively. These findings appear sufficiently similar to those in humans to suggest that cynomolgus monkeys can serve as a suitable model of human cardiac disease. Our data should also prove useful for surveying cardiac dysfunction in monkeys.

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“…Those changes were particularly apparent in males ( Supplementary Table S2). Previous studies have found that CO does not change, whereas SV increases with aging in humans [12,25].…”

Section: Discussionmentioning

confidence: 79%

Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range

et al. 2020

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“…In patients with high risk, physiological aging (CA= BA) was observed in 9.4% (9/96) cases, in 31.3% (30/96) cases, a slowed aging rate (SAR) was recorded, and an accelerated aging rate (AAR) was observed in 59.4% (57/96) patients. As evidenced by numerous studies various factors may contribute to accelerated aging [10]. Thus, Emelyanov V.V.…”

Section: Resultsmentioning

confidence: 99%

Effects of Biological Age and Aging Rates on the Expression of Risk Factors in Patients With Arterial Hypertension and Type 2 Diabetes Mellitus

Nemtsova¹

2019

Med. and Ecol. probl.

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Objective: biological age has been given a large role in determining the significance and contribution to the general concept of risk factors in recent years. The relevance of determining the rate of aging is also due to the fact that the rate of aging may have a real prognostic value for assessing the health of both an individual and groups exposed to one or another risk factor. The aim of the present paper was to study the biological age, to assess the rate of aging in persons with high cardiovascular risk (CVR), as well as to carry out search for possible correlations of age-related indices of aging and some risk factors. Methods: During 2016-2018, 96 patients (42 men and 54 women), whose mean age was 62.66 ± 4.21 years, with AH stage II (disease duration of 10.2 ± 3.7 years) and DM2T, disease duration of 4.1 ± 2.4 years) were included in the study. The biological age and rate of aging was investigated by the method of V.P. Voitenko et al. Results: Physiological aging was observed in 9.38% (9/96) patients, in 31.25% (30/96) there was a delayed rate of aging, in 59.38% (57/96) - an accelerated rate of aging (ARA). ARA was characterized by a more pronounced body mass index, fasting blood glucose level, insulin resistance degree. In men, ARA was observed 2 times more frequently than in women. The most significant correlations between the indices characterizing the biological age and the rate of aging were recorded with systolic, diastolic and pulse arterial pressure. Conclusion: Thus, the complex of anthropometric and metabolic disorders can act as an initiating syndrome of accelerated aging, thereby aggravating the existing cardiovascular risk.

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“…Although prolonged lifespan does not always correspond to health span, extreme longevity is often accompanied by reduced or delayed morbidity (111,112). This led to the hypothesis that the aging-related decay is neither necessary nor irreversible (111).…”

Section: Genetics Of Extreme Longevity: Can This Inform New Therapy Smentioning

confidence: 99%

Molecular therapies delaying cardiovascular aging: disease- or health-oriented approaches

et al. 2020

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Regenerative medicine is a new therapeutic modality that aims to mend tissue damage by encouraging the reconstitution of physiological integrity. It represents an advancement over conventional therapies that allow reducing the damage but result in disease chronicization. Age-related decline in spontaneous capacity of repair, especially in organs like the heart that have very limited proliferative capacity, contributes in reducing the benefit of conventional therapy. ncRNAs are emerging as key epigenetic regulators of cardiovascular regeneration. Inhibition or replacement of miRNAs may offer reparative solutions to cardiovascular disease. The first part of this review article is devoted to illustrating novel therapies emerging from research on miRNAs. In the second part, we develop new therapeutic concepts emerging from genetics of longevity. Prolonged survival, as in supercentenarians, denotes an exceptional capacity to repair and cope with risk factors and diseases. These characteristics are shared with offspring, suggesting that the regenerative phenotype is heritable. New evidence indicates that genetic traits responsible for prolongation of health span in humans can be passed to and benefit the outcomes of animal models of cardiovascular disease. Genetic studies have also focused on determinants of accelerated senescence and related druggable targets. Evolutionary genetics assessing the genetic basis of adaptation and comparing successful and unsuccessful genetic changes in response to selection within populations represent a powerful basis to develop novel therapies aiming to prolong cardiovascular and whole organism health.

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The Impact of Aging on Cardio and Cerebrovascular Diseases

Cited by 76 publications

References 257 publications

Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range

Echocardiographic evaluation of cardiac function in cynomolgus monkeys over a wide age range

Effects of Biological Age and Aging Rates on the Expression of Risk Factors in Patients With Arterial Hypertension and Type 2 Diabetes Mellitus

Molecular therapies delaying cardiovascular aging: disease- or health-oriented approaches

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