The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle

Gutiérrez-Casado, Elena; Khraiwesh, Husam; López-Domínguez, José A; Montero-Guisado, Jesús; López-Lluch, Guillermo; Navas, Plácido; Cabo, Rafael de; Ramsey, Jon J.; González-Reyes, José A.; Villalba, José M.

doi:10.1093/gerona/gly161

Cited by 36 publications

(41 citation statements)

References 38 publications

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“…CR is a long-term dietary intervention characterized by reduced caloric intake, but malnutrition and deficiency of essential nutrients are prevented [12,13]. The health advantages of CR resulting in lifespan extension are well established in many studies [14,15]. Moreover, accumulating evidence indicates that CR represents an effective strategy to reduce weight, influences adipose tissues plasticity, and modifies endocrinological function of adipose tissue and skeletal muscle.…”

Section: Introductionmentioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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: It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.

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Section: Introductionmentioning

confidence: 99%

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Senesi

Luzi

Terruzzi

2020

IJMS

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“…Furthermore, they found decreased muscle inflammation, suggesting another beneficial role of CR on muscle biology. The study by Gutierrez-Casado et al also showed a prominent effect of CR on autophagy in the muscle [68]. CR resulted in decreased levels of p62, suggesting a possible increase in autophagy flux.…”

Section: Musclementioning

confidence: 84%

The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention

Chung

2019

Nutrients

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Autophagy is an important housekeeping process that maintains a proper cellular homeostasis under normal physiologic and/or pathologic conditions. It is responsible for the disposal and recycling of metabolic macromolecules and damaged organelles through broad lysosomal degradation processes. Under stress conditions, including nutrient deficiency, autophagy is substantially activated to maintain proper cell function and promote cell survival. Altered autophagy processes have been reported in various aging studies, and a dysregulated autophagy is associated with various age-associated diseases. Calorie restriction (CR) is regarded as the gold standard for many aging intervention methods. Although it is clear that CR has diverse effects in counteracting aging process, the exact mechanisms by which it modulates those processes are still controversial. Recent advances in CR research have suggested that the activation of autophagy is linked to the observed beneficial anti-aging effects. Evidence showed that CR induced a robust autophagy response in various metabolic tissues, and that the inhibition of autophagy attenuated the anti-aging effects of CR. The mechanisms by which CR modulates the complex process of autophagy have been investigated in depth. In this review, several major advances related to CR’s anti-aging mechanisms and anti-aging mimetics will be discussed, focusing on the modification of the autophagy response.

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“…Muscle mass loss is considered normal with age; however, calorie restricted diets can slow aging and protect muscle. Therefore, Gutierrez‐Casado et al 64 . assessed CR and age on markers of mitophagy.…”

Section: Resultsmentioning

confidence: 99%

“…Muscle mass loss is considered normal with age; however, calorie restricted diets can slow aging and protect muscle. Therefore, Gutierrez-Casado et al 64 assessed CR and age on markers of mitophagy. Ten-week-old mice were divided into four groups: a control group and three CR groups with different sources of dietary fat (lard, fish oil, or soybean oil) for 6 or 18 months.…”

Section: Fasting or Calorie Restriction And Mitophagymentioning

confidence: 99%

The effect of fasting or calorie restriction on mitophagy induction: a literature review

Mehrabani

Bagherniya

Askari

et al. 2020

J cachexia sarcopenia muscle

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Mitochondrial dysfunction can be a major cause of a wide range of age-related diseases. Maintaining the normal homeostasis of mitochondria population plays an important role in ensuring people's health, which is done through the mitophagy process. Among the various stimuli for the onset of mitophagy, caloric restriction (CR) is one of the strongest non-genetic triggers for initiating the mitophagy process. The primary objective of this paper is to review the literature assessing the effect of CR on mitophagy. Medline, Web of Science, Scopus, and Google Scholar databases was searched from inception to 1 August 2019. Reference lists from all selected articles were also examined for additional relevant studies. The evidence regarding the effect of fasting or CR on mitophagy is still limited. In addition, the methodological approaches of the studies are too heterogeneous in terms of types of food restriction, study duration, and targeted tissues. Most of the studies showed that fasting or CR induced mitophagy and mitophagy-related markers such as Binp3 and Parkin. However, some studies demonstrated that mitophagy occurred both in fasting and fed state with no significant differences or may be induced in fed state. Study on the muscle tissue of subjects after exercise showed that mitophagy was upregulated in the fed state. It has been demonstrated that mitophagy in the muscle was lowered in the absence of AMP-dependent kinase and fibroblast growth factor 21 genes, both in fasted and fed conditions. Current evidence overwhelmingly suggests that CR and fasting induce mitophagy and mitophagy-related markers. Based on the current evidence that we reviewed here, it could be concluded that fasting or CR has a promising role as a novel and practical approach in the prevention of age-related diseases without any side effects by inducing mitophagy in different organs of the body. More studies will be required in future to clarify the relationship between food deprivation and mitophagy. Further studies using a variety of different types of CR and fasting states are also warranted to determine the best approach for inducing mitophagy and improving health.

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The Impact of Aging, Calorie Restriction and Dietary Fat on Autophagy Markers and Mitochondrial Ultrastructure and Dynamics in Mouse Skeletal Muscle

Cited by 36 publications

References 38 publications

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions

The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention

The effect of fasting or calorie restriction on mitophagy induction: a literature review

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