The impact of ageing on stroke subtypes, length of stay and mortality: study in the province of Teruel, Spain

Modrego, Pedro J.; Pina, M. A.; Lerín, F. J.

doi:10.1034/j.1600-0404.2003.00168.x

Cited by 7 publications

(6 citation statements)

References 28 publications

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“…The incidence of cerebrovascular diseases among the elderly is the highest, however, the pathophysiological mechanism of brain responding to cerebral ischemia in the elderly is still poorly understood (11). Old age is a major risk factor for the diseases and is associated with their increasing incidence and mortality (12,13). In most developed countries, ~87% of strokes are ischemic and originate from intracranial arterial occlusion (IAO), being the major cause of patient death and adult disability (14,15).…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of vascular intervention combined with intravenous thrombolysis in treatment of acute intracranial arterial occlusion

et al. 2020

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Efficacy and safety of vascular intervention combined with intravenous thrombolysis (IVT) was investigated in the treatment of acute intracranial arterial occlusion (AIAO). Ninety-two patients with AIAO treated in People's Hospital of Tongchuan from January 2014 to February 2016 were enrolled in this retrospective study. Forty-two patients were treated with vascular intervention (control group), while another 50 patients were treated with vascular intervention combined with IVT (study group). They were observed in terms of the improvement of clinical efficacy after treatment, the comparison of complications after treatment, the National Institute of Health Stroke Scale (NIHSS) score after treatment, the modified Rankin Scale (mRS) score at 3 months after treatment, and the Mini-Mental State Examination (MMSE) score at 3 months after treatment. Compared with those in the control group, patients in the study group had statistically significantly higher marked effectiveness and statistically significantly lower ineffectiveness (P= 0.018), and a statistically significantly higher overall effective rate (P=0.042). The NIHSS score in the study group was statistically significantly lower than that in the control group after treatment (P=0.001). There was a statistically significant difference between the two groups in the mRS score at 3 months after treatment (Z=8.764, P>0.05). Compared with those in the control group, patients in the study group had a statistically significantly higher MMSE score after treatment, and a statistically significantly lower total incidence of postoperative complications (P=0.001). Vascular intervention combined with IVT has good efficacy and high safety in the treatment of AIAO, and the combination can statistically significantly improve patients' quality of life, so it has a good clinical application value.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of vascular intervention combined with intravenous thrombolysis in treatment of acute intracranial arterial occlusion

et al. 2020

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“…Since we have still a low rate of immigration, the population is ethnically homogeneous. The mean approximate incidence rate of stroke was 155/ 100,000 per year from 1994 to 1998 [14], but it rose to 183 in the period 1999 -2001 [15]. The community of Bajo Aragón is located in the north of the province and its population is approximately half that of the entire province.…”

Section: Study Population and Methodsmentioning

confidence: 99%

Recurrence and survival after first-ever stroke in the area of Bajo Aragon, Spain. A prospective cohort study

Modrego¹,

Mainar²,

Turull³

2004

Journal of the Neurological Sciences

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“…Aging is an important risk factor for Alzheimer's disease (AD) [21, 22]. But the factors that cause the relatively benign process of normal brain aging to the pathological cascade that leads to AD are unknown.…”

Section: Discussionmentioning

confidence: 99%

Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice

Lee

Oliynyk

Jung³

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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The function and the role of glucosylceramide have not been well studied in the central nervous system. This study was aimed to investigate the possible roles of glucosylceramide in memory function in aged mice. Glucosylceramide (50 mg/kg, p.o.) showed memory enhancing activity after 3-month treatment in the aged mice (C56BL/6, 18–20 months old) through Y-maze, novel objective test, and Morris water maze test. Long-term treatment of glucosylceramide decreased the expression of iNOS and COX-2 in the brain of aged mice. The LPS-induced mRNA level of iNOS, COX-2, IL-1β, and TNF-α was reduced by the acute treatment with glucosylceramide in adult mice. These results suggest that glucosylceramide plays an important role in anti-inflammatory and memory enhancement, and it could be a potential new therapeutic agent for the treatment of neurodegenerative diseases such as Alzheimer's disease.

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The impact of ageing on stroke subtypes, length of stay and mortality: study in the province of Teruel, Spain

Cited by 7 publications

References 28 publications

Efficacy and safety of vascular intervention combined with intravenous thrombolysis in treatment of acute intracranial arterial occlusion

Efficacy and safety of vascular intervention combined with intravenous thrombolysis in treatment of acute intracranial arterial occlusion

Recurrence and survival after first-ever stroke in the area of Bajo Aragon, Spain. A prospective cohort study

Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice

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