The impact of age on fertility rate in patients who underwent microsurgical varicocelectomy

Bolat, Mustafa Suat; Kocamanoglu, Fatih; Gülşen, Murat Taner; Sengul, Mesut; Aşçı, Ramazan

doi:10.1111/and.13234

Cited by 9 publications

(7 citation statements)

References 37 publications

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“… 26 On the contrary, the patient's age seems not to be related with the post‐surgery seminal improvement. This result is in contrast with other reports 41 , 42 but, probably, in our setting the duration of varicocele is a more a relevant parameter than age at surgery. Taken together, these results could help the clinician in the current clinical approach to varicocele‐related male infertility.…”

Section: Discussioncontrasting

confidence: 99%

Improvement of sperm morphology after surgical varicocele repair

et al. 2021

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Section: Discussioncontrasting

confidence: 99%

Improvement of sperm morphology after surgical varicocele repair

et al. 2021

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“…On the contrary, the patient's age seems not to be related with the post-surgery seminal improvement. This result is in contrast with other reports 38,39 but, probably, in our setting the duration of varicocele is a more a relevant parameter than age at surgery. In our cohort, seminal improvement is detected only in patients treated with sub-inguinal ebectomy.…”

Section: Discussioncontrasting

confidence: 99%

Improvement of Sperm Morphology After Surgical Varicocele Repair

Morini

Spaggiari

Daolio

et al. 2021

Preprint

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Setting: A causative relationship between varicocele and impairment of semen quality has been largely investigated in the context of male infertility, although its clinical benefit remains controversial.Objective: To investigate the effect of varicocele correction on detailed morphologic microscopic semen parameters in a large homogeneous cohort of patients and to evaluate which factors could predict semen improvement after the surgical treatment.Design: An observational, retrospective cohort study was carried out including all patients undergoing surgical treatment for varicocele from September 2011 to March 2020 in the same clinical centre. Enrolled males performed at least one semen analysis before and one after surgical varicocele correction. Primary outcome was the detailed morphologic microscopic sperm evaluation. Secondary outcomes were conventional semen analyses.Results: 121 males (mean age 24.6+6.1 years) were enrolled. Using detailed morphologic microscopic sperm evaluation, a significant morphological improvement was recorded, with a reduction in head and tail abnormalities. Moreover, a significant increase in sperm concentration (p=0.015) and percentage of progressive and total motility (p=0.022 and p=0.039) were observed after surgery. The multivariate logistic analysis identified the ultrasonography varicocele degree before surgery as a main predictor of the sperm concentration improvement (p=0.016), with the highest improvement for varicocele of I and II degree. Conclusion: For the first time, the detailed morphologic microscopic sperm evaluation highlights a relevant reduction in sperm abnormalities after varicocele surgery, showing its potential application in clinical practice.

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“…We also evaluated whether age was associated with postoperative seminal recovery determined a significant increase in sperm parameters in patients aged ≤30 years compared with those aged >30 years. This result contradicts the findings reported by Morini et al but it is consistent with other reports [24–26] …”

Section: Discussionsupporting

confidence: 78%

Effect of varicocelectomy on detailed sperm morphology parameters

Yaris¹,

Kilinc²

2022

Medicine

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Although many studies suggest that varicocelectomy leads to improvement in semen parameters and morphology, its clinical efficacy remains controversial. The detailed morphological parameters described in the World Health Organization guidelines are important in terms of showing the effect of microsurgical subinguinal varicocelectomy on morphological changes. An observational, retrospective clinical cohort study was conducted with patients followed up from January 2018 to August 2021. This study included the data of 79 patients who met the criterion of undergoing at least 2 detailed morphological evaluations before and after surgery. All operations were performed by the same surgical team using the microsurgical subinguinal varicocelectomy technique. The mean age of the patients was 30.25 years. Of the patients, 63 underwent left-sided varicocelectomy and 16 underwent bilateral surgery. The sperm analysis revealed statistically significant increases in sperm volume ( P = .006), sperm concentration ( P = .003), total sperm count ( P = .001), progressive sperm motility ( P < .001), and normal morphology ( P < .001). In the detailed morphological evaluation, except for the elongated head anomaly ( P = .037), no other statistically significant changes were found in relation to sperm head, tail, and neck anomalies after surgery. This study makes an important contribution to the literature, being the first to use the subinguinal microscopic varicocelectomy technique in detailed morphological semen evaluation. We consider that detailed morphology examination in the selection and treatment of infertile patients may be useful in evaluating the efficacy of varicocelectomy.

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The impact of age on fertility rate in patients who underwent microsurgical varicocelectomy

Cited by 9 publications

References 37 publications

Improvement of sperm morphology after surgical varicocele repair

Improvement of sperm morphology after surgical varicocele repair

Improvement of Sperm Morphology After Surgical Varicocele Repair

Effect of varicocelectomy on detailed sperm morphology parameters

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