The impact of age on the incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis

Katsinelos, Panagiotis

doi:10.20524/aog.2017.0203

Cited by 6 publications

(5 citation statements)

References 21 publications

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“…Although PEP has a very guarded prognosis and may be fatal in some cases, most previous studies were performed in high-volume centers [16,17]. Although these risk factors are consistently reported in the medical guidelines and references, complete prevention of PEP has not been achieved because of the possible presence of other underlying risk factors for PEP [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Risk Factors for Post-Endoscopic Retrograde Pancreatography Pancreatitis: A Retrospective Chart Review in a Regional Hospital in Japan

et al. 2019

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Background: Endoscopic retrograde pancreatography (ERCP) is sometimes complicated by post-ERCP pancreatitis (PEP), which is a severe adverse effect. Objective: The present study was performed to (i) evaluate the risk factors for PEP and (ii) compare the risk of PEP after ERCP performed in the off hours versus regular hours. Methods: This retrospective study included 374 patients who underwent ERCP from January 2013 to December 2017. Among these patients, 38 (10.2%) developed PEP. The potential risk factors for PEP were evaluated by multivariate regression analysis, and the risk of PEP was compared between ERCP performed during regular hours and off hours. Results: The independent risk factors for PEP were a relatively younger age (< 75 years; p = 0.024), female sex (p = 0.002), a history of pancreatitis (p = 0.044), and performance of pancreatography (p = 0.010). Use of a diclofenac suppository and performance of pancreatic stenting were not preventive for PEP after ERCP. The complication rate of PEP did not differ between ERCP performed during the off hours versus regular hours. Conclusions: A relatively younger age (< 75 years), female sex, a history of pancreatitis, and performance of pancreatography were potential risk factors for PEP, whereas the risk of PEP was not different between ERCP performed during the off hours versus regular hours.

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Section: Introductionmentioning

confidence: 99%

Risk Factors for Post-Endoscopic Retrograde Pancreatography Pancreatitis: A Retrospective Chart Review in a Regional Hospital in Japan

et al. 2019

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“…With advancing age, there is progressive pancreatic atrophy and fibrosis, that is, pancreatic senescence, resulting in tissue destruction and chronic pancreatitis (CP) [ 72 ]. CP is an irreversible disease of chronic pancreatic fibrosis.…”

Section: The Role Of Senescence In Types Of Pancreatic Diseasesmentioning

confidence: 99%

Changes in Pancreatic Senescence Mediate Pancreatic Diseases

Bian

Xiao

et al. 2023

IJMS

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In recent years, there has been a significant increase in age-related diseases due to the improvement in life expectancy worldwide. The pancreas undergoes various morphological and pathological changes with aging, such as pancreatic atrophy, fatty degeneration, fibrosis, inflammatory cell infiltration, and exocrine pancreatic metaplasia. Meanwhile, these may predispose the individuals to aging-related diseases, such as diabetes, dyspepsia, pancreatic ductal adenocarcinoma, and pancreatitis, as the endocrine and exocrine functions of the pancreas are significantly affected by aging. Pancreatic senescence is associated with various underlying factors including genetic damage, DNA methylation, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and inflammation. This paper reviews the alternations of morphologies and functions in the aging pancreas, especially β-cells, closely related to insulin secretion. Finally, we summarize the mechanisms of pancreatic senescence to provide potential targets for treating pancreatic aging-related diseases.

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“…Evidence suggests that the patient's inflammatory response to pancreatic duct imaging and instrumentation contribute to the development of PEP [9,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Predictive Factors for Prophylaxis Effect of Naproxen in Post Endoscopic Pancreatitis

Tanaj

Кондов

Krasniqi

2022

JMS

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Endoscopic retrograde cholangiopancreatography (ERCP) can be associated with complications like post-ERCP pancreatitis (PEP). We aimed to examine the possible influence of selective demographic and clinical factors on efficacy of periprocedural 500 mg Naproxen single dose rectal administration in prevention of PEP in patients after diagnostic or therapeutic ERCP.This randomized prospective mono-centric clinical study was implemented during January-April 2022 on 30 patients referred for ERCP at the University Clinical Center of Kosovo-Prishtina. Before ERCP, all patients received periprocedural 500mg Naproxen single dose rectal administration in prevention of PEP. The levels of amylase, lipase, and CRP were measured before ERCP, and 4/24h after.The incidence of PEP was 16,67% (5/ 30) -2 (11,76%) of the male and 3 (23,08%) of the female (p=0,4101). No significant differences between the patients without/with PEP was found related to age (p=0,8674), BMI (p=0,5591) and duration of procedure (p=0,5590). Pancreatic duct wire cannulation happened in 5 (16,67%) patients, while only 2 (40%) of them developed PEP. Amylases levels 24h after ERCP were significantly higher in patients with PEP (p=0,0005). Between patients without/with PEP there were significant differences in lipase levels before/4h/24h after ERCP for p=0,0451 vs. p=0,0278 vs. p=0,005 respectively. Related to CRP levels, no significant difference was found between the groups at any measurement time. Analyzed potential influencing factors didn't show significant influence on efficacy of Naproxen in prevention of PEP after ERCP. More extensive controlled trials are underway in Republic of Kosovo to precise the effects of Naproxen in reduction of PEP after ERCP.

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The impact of age on the incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis

Cited by 6 publications

References 21 publications

Risk Factors for Post-Endoscopic Retrograde Pancreatography Pancreatitis: A Retrospective Chart Review in a Regional Hospital in Japan

Risk Factors for Post-Endoscopic Retrograde Pancreatography Pancreatitis: A Retrospective Chart Review in a Regional Hospital in Japan

Changes in Pancreatic Senescence Mediate Pancreatic Diseases

Predictive Factors for Prophylaxis Effect of Naproxen in Post Endoscopic Pancreatitis

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