The Impact of Age, Body Mass Index and Testosterone on Erectile Dysfunction

Kratzik, Christian; Schatzl, Georg; Lunglmayr, G; Rücklinger, Ernst; Huber, Johannes

doi:10.1097/01.ju.0000162049.95483.51

Cited by 69 publications

(42 citation statements)

References 19 publications

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“…16 It is well-known that androgen replacement restore EF in hypogonadal men. 17 Kratzik et al 18 revealed evidence of an impact of testosterone and bioavailable testosterone in cases of severe ED, albeit a significant association was only found in men with severe ED and low levels of serum bioavailable testosterone compared with men with normal levels of serum bioavailable testosterone. These findings show that low testosterone becomes more important for men with severe ED rather than for men with moderate or mild ED.…”

Section: Discussionmentioning

confidence: 99%

Severity of erectile dysfunction in married impotent patients: Interrelationship with anthropometry, hormones, metabolic profiles and lifestyle

et al. 2006

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Objective: This study was designed to evaluate the effects of risk factors for erectile dysfunction (ED) or cardiovascular disease on the disease severity in impotent men. Methods: A total of 87 men, 25-75 years old (mean age, 53.4) were included in the study. Patients were evaluated with anthropometry, hormones, metabolic profiles and lifestyle. Baseline erectile function (EF) was evaluated using the International Index of Erectile Function (IIEF). The severity of ED was classified into the following four grades based on the six-item EF domain of the IIEF: severe (6-10); moderate (11-16); mild to moderate (17-21); and mild (22-25). Patients were deemed to have metabolic syndrome (MS) if they had three or more of five criteria according to National Cholesterol Education Program, with some modification. Results: Of 87 patients, 15 patients (17.2%) had mild , 11 (12.6%) had mild to moderate, 33 (37.9%) had moderate and 28 (32.3%) had severe ED. There was no correlation between scores of IIEF or EF domain and continuous parameters. On the multivariate model used , hypertensive patients had 26-fold higher risk (odds ratio, 26.195; 95% confidence interval, 1.463-46.072; P = 0.027) of severe ED than those without hypertension. Other factors were not significant. Conclusion:The results of the study indicate that MS might not influence the severity of ED in impotent men. However, our findings suggest that hypertension plays a role in the disease severity in these patients.

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Section: Discussionmentioning

confidence: 99%

Severity of erectile dysfunction in married impotent patients: Interrelationship with anthropometry, hormones, metabolic profiles and lifestyle

et al. 2006

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“…Indeed, hypogonadism was shown to be associated with a decline in erectile function and in the erectile function domain scores on the IIEF. 6,59,60 In a study performed by Kratzik et al 60 on 675 workers aged from 45-60 years, screened for their erectile function and serum testosterone levels, severe cases of ED (IIEF-5 score 7 or less) were significantly associated with a decrease in total testosterone and bioavailable testosterone (BAT). Individuals with low bioavailable testosterone (f1 ng ml 21 ) had a three times higher risk of severe ED compared with men with BAT greater than 1 ng ml 21 (odds ratio: 3.045, 95% CI: 1.08828.522, P50.034), even after adjustment for age and body mass index.…”

Section: Edmentioning

confidence: 99%

Impact of androgen deprivation therapy on sexual function

Mazzola

Mulhall²

2012

Asian J Androl

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Many patients with prostate cancer for whom androgen deprivation therapy (ADT) is indicated are young and desire to remain sexually active. In such patients, the side effects of androgen therapy on sexual function can be a source of serious reduction in overall quality of life. Providing the appropriate treatment options in this patient population is therefore essential. Nevertheless, treating such patients is challenging and an understanding of the underlying mechanisms of sexual physiology and pathophysiology is crucial to optimal patient care. In this paper, we reviewed what was known regarding the effects of ADT on sexual function in animal models and we also provided a detailed review on the effects of ADT on sexual health in humans and its treatment.

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“…Each year, increase in age reduces the score of the International Index of Erectile Function in 0.195 affecting the risk for erectile dysfunction. 42 Habits like smoking and the presence of dyslipidemia were not associated with erectile dysfunction in the study by Abdo et al, 47 but in the one by Bacon et al, 20 who found that smoking is associated with increased prevalence of erectile dysfunction. Prevention against smoking represents an important approach to reduce the risk of erectile dysfunction.…”

Section: Discussionmentioning

confidence: 62%

“…It was verified that the increase in BMI of 1 kg m -2 reduces the score of the International Physical Activity Index at 0.141 regardless of age and increases by 7.6% the risk for erectile dysfunction, making it a strong association. 42 Otherwise, the decrease in BMI is associated with an increased score of the International Index of Erectile Function. 8 In this study, the association of erectile dysfunction and obesity did not occur; however, there was a tendency (P ¼ 0.062).…”

Section: Discussionmentioning

confidence: 99%

Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years

et al. 2011

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The aim of this study is to evaluate the association between physical activity level and physical fitness with erectile dysfunction in men aged 40-75 years. We examined 180 men aged 40-75 years. The individuals were evaluated for age, presence of dyslipidemia and smoking and for anthropometric parameters for the characterization of body mass index. For assessing the level of physical fitness, a test was performed to measure the indirect maximum oxygen consumption. The evaluation of erectile function was made by the International Index of Erectile Function questionnaire and assessment of physical activity level by the International Physical Activity questionnaire in its short version. This study showed that younger men with higher physical activity and better physical fitness are less likely to suffer from erectile dysfunction. Multivariable analysis through logistic regression showed that age (odds ratio (OD) ¼ 1.15; 95% confidence interval (95% CI) ¼ 1.07-1.23), physical activity (OD ¼ 10.38; 95% CI ¼ 3.94-27.39) and physical fitness (OD ¼ 4.62; 95% CI ¼ 1.75-12.25) were independent variables associated with erectile dysfunction. This study reinforces the concept that healthy habits have a direct effect on erectile function.

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The Impact of Age, Body Mass Index and Testosterone on Erectile Dysfunction

Abstract: BMI contributes strongly to ED. Low T or BAT are only relevant if IIEF-5 questionnaire results in severe ED.

Cited by 69 publications

References 19 publications

Severity of erectile dysfunction in married impotent patients: Interrelationship with anthropometry, hormones, metabolic profiles and lifestyle

Severity of erectile dysfunction in married impotent patients: Interrelationship with anthropometry, hormones, metabolic profiles and lifestyle

Impact of androgen deprivation therapy on sexual function

Erectile dysfunction association with physical activity level and physical fitness in men aged 40–75 years

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