The impact of age and BMI on oocyte maturation and embryo development

Al-Obaidi, Manal Taha; Mahdi, Huda Bahjat; Alwasiti, Estabraq

doi:10.4066/biomedicalresearch.29-17-3756

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The observations were contrary to the study by (Al-Obaidi, et al [11] ) which showed that triggering day were markedly high with progesterone elevation than in the nonprogesterone elevation groups (Wu, et al [14] ). The explanation is that, when FSH is used in stimulation, it induces bearing of LH receptors in granulosa cells, which leads to increase sensitivity to the same LH, which in turn could conduct to create the rise of progesterone prematurely, even with low level of serum LH (Glamoclija, et al [15] ).…”

Section: Discussioncontrasting

confidence: 91%

Evaluation of Serum Progesterone Level on the Day of hCG Injection on Clinical Outcome of Antagonist Protocol in ICSI Cycles

Al-Bader¹,

Selman²

2019

IJEIR

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Progesterone's premature rise during late follicular phase will negatively affect the outcome of antagonist protocol in the Intracytoplasmic sperm injection (ICSI) cycles, on trigger day progesterone level above 1.5 ng/ml create different endometrial gene expression profiles, lead to asynchrony between the endometrium and the fresh embryo transfer. Enhanced FSH-stimulation only without LH support considers as the main cause for premature progesterone rise. To analyze the influence of progesterone rise on trigger day by hCG on clinical outcomes and pregnancy rates of fresh embryo transfer in the ICSI by the use of antagonist protocol. 60 Iraqi infertile women were enrolled in this interventional study stimulated by antagonist protocol, they were subdivided according to the level of serum progesterone on day of trigger by hCG into 30 infertile women with serum progesterone ≤1.5 ng/ml and thirty infertile women with serum progesterone >1.5 ng/ml. The maturation, fertilization, cleavage, implantation, biochemical and clinical pregnancy rates were all measured in both groups. women with serum progesterone level >1.5 ng/ml on hCG trigger day, showed longer stimulation days with significant difference (P < 0.02) and highly significant increment in the mean level of serum progesterone and mean P 4 /E 2 ratio (P <0.001) and of serum LH (P <0.010). While there was significant decrease in implantation percentage (P =0.012) and in biochemical and clinical pregnancy rate (P =0.010) in comparison to women with serum progesterone level ≤ 1.5 ng/ml on day of hCG trigger. Measurement of serum progesterone and P 4 /E 2 ratio on trigger day by hCG are considering as an important predictor factor for the clinical outcome (implantation rate; biochemical and clinical pregnancy).

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Section: Discussioncontrasting

confidence: 91%

Evaluation of Serum Progesterone Level on the Day of hCG Injection on Clinical Outcome of Antagonist Protocol in ICSI Cycles

Al-Bader¹,

Selman²

2019

IJEIR

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“…The present study displayed the absence of a significant difference in mean age between pregnant and non-pregnant women, which agreed with the result of (Zhang, Bu, Su, & Sarah Hamza Herez, et al: Effect of Bisphenol A Level in Follicular Fluid on ICSI OutCome Zhu, 2018) who noted a reasonable low outcome in women aged 35-37 years during the first three ovarian stimulation cycles. In opposite other studies concluded that the female age is the fundamental predictor of pregnancy after assisted reproduction technique and there is a negative relation between increasing female age and the success rate of ICSI (Al-Obaidi, Mahdi, & Alwasiti, 2018;Fahad, Al-Murshedi, & Al-Khafaji, 2015). Also, the comparison between the Pregnant and Non-Pregnant women, showed that there were no significant differences in other demographic characteristics, namely body mass index (BMI), residency, educational level, occupation, lifestyle habits, type, and duration of infertility, and history of previous IVF treatment.…”

Section: Discussionmentioning

confidence: 96%

Effect of Bisphenol A Level in Follicular Fluid on ICSI OutCome

2022

pnr

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Background: Infertility is the disability of a couple to obtain pregnancy after one year of sexual intercourse that is unprotected and regular. Bisphenol A (BPA) is an industrial chemical, that is produced in huge quantities worldwide. It is utilized as a raw material in multiple industries, and assorted as one of the endocrine-disrupting chemicals, as it can interfere with hormone activity. Bisphenol A may have a role in the reproduction process and may impact oocyte's maturity, meiotic division of germ cells, or fertilization rate. This study aimed to assess the impact of Bisphenol A level in follicular fluid on ICSI outcome.

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“…Women, ages 20–24 yr old have the best ability to get pregnant; after age 30, a progressive decline in this ability occurs with age ( 2 , 3 ). Both the gradual depletion of oocytes and the reduction in oocyte quality, at least after the age of 31, are important reasons for decreased fertility capacity ( 4 – 6 ).…”

Section: Introductionmentioning

confidence: 99%

Causal Effects of Body Mass Index and Maternal Age on Oocyte Maturation in Assisted Reproductive Technology: Model-Average Causal Effect and Bayesian LASSO Method

Alizadeh¹,

Omani-Samani²,

Mansournia³

et al. 2020

ijph

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Background: Body Mass Index (BMI) and maternal age are related to various disorders of the female reproductive system. This study aimed to estimate the causal effects of BMI and maternal age on the rate of metaphase II oocytes (MII) using a new statistical method based on Bayesian LASSO and model averaging. Methods: This investigation was a historical cohort study and data were collected from women who underwent assisted reproductive treatments in Tehran, Iran during 2015 to 2018. Exclusion criteria were gestational surrogacy and donor oocyte. We used a new method based on Bayesian LASSO and model average to capture important confounders. Results: Overall, 536 cycles of 398 women were evaluated. BMI and Age had inverse relationships with the number of MII based on univariate analysis, but after adjusting the effects of other variables, there was just a significant association between age and the number of MII (adjusted incidence rate ratio (aIRR) of age =0.989, 95% CI: [0.979, 0.998], P=0.02). The results of causal inference based on the new presented method showed that the overall effects of age and BMI of all patients were significantly and inversely associated with the number of MII (both P<0.001). Therefore the expected number of MII decreased by 0.99 for an increase of 1 year (95% CI: [-1.00,-0.97]) and decreased by 0.99 for each 1-unit increase in BMI (95% CI: [-1.01,-0.98]). Conclusion: Maternal age and BMI have significant adverse casual effects on the rate of MII in patients undergoing ART when the effects of important confounders were adjusted.

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The impact of age and BMI on oocyte maturation and embryo development

Cited by 5 publications

References 16 publications

Evaluation of Serum Progesterone Level on the Day of hCG Injection on Clinical Outcome of Antagonist Protocol in ICSI Cycles

Evaluation of Serum Progesterone Level on the Day of hCG Injection on Clinical Outcome of Antagonist Protocol in ICSI Cycles

Effect of Bisphenol A Level in Follicular Fluid on ICSI OutCome

Causal Effects of Body Mass Index and Maternal Age on Oocyte Maturation in Assisted Reproductive Technology: Model-Average Causal Effect and Bayesian LASSO Method

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