The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

Hortobágyi, Tibor; Vetrovsky, Tomas; Balbim, Guilherme Moraes; Silva, Nárlon Cássio Boa Sorte; Manca, Andrea; Deriu, Franca; Kolmos, Mia; Kruuse, Christina; Liu‐Ambrose, Teresa; Radák, Zsolt; Váczi, Márk; Johansson, Hanna; Santos, Paulo Cezar Rocha dos; Franzén, Erika; Granacher, Urs

doi:10.1016/j.arr.2022.101698

Cited by 33 publications

(19 citation statements)

References 239 publications

(360 reference statements)

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“…Moreover, both DNAm-PhenoAge acceleration and DNAmGrimAge acceleration showed that a higher level of physical fitness suppresses the progress of aging. The health-promoting effects of exercise are well documented (Hortobágyi et al 2022;Quan et al 2020;Radak et al 2013), and this study also demonstrates that these changes could be associated with DNA methylation. Surralles et al (1999) demonstrated that telomere shortening could be affected by histone acetylation, therefore influenced by epigenetics.…”

Section: Discussionsupporting

confidence: 59%

No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

et al. 2023

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Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging are strongly influenced by environmental and lifestyle factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study, we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNA methylation-based estimation of TL (DNAmTL), and DNA methylation-based biomarkers of aging of master rowers (N = 146) and sedentary subjects (N = 95), aged between 37 and 85 years. It was found that the TL inversely correlated with chronological age. We could not detect an association between telomere length and VO2max, vertical jump, and working memory by RT-PCR method, while these physiological test results showed a correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there are no strong beneficial effects of exercise or physiological fitness on telomere shortening, however, the degree of DNA methylation is associated with telomere length.

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Section: Discussionsupporting

confidence: 59%

No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

et al. 2023

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“…8 Aerobic exercise has been shown to increase blood circulation in fronto-parietal and hippocampal areas, which are known to be important brain regions for motor learning and memory. 9 Since people with PD are found to have problems with memory consolidation, it would be interesting to determine whether aerobic exercise can induce similar beneficial effects.…”

Section: Introductionmentioning

confidence: 99%

Influences of Aerobic Exercise on Motor Sequence Learning and Corticomotor Excitability in People With Parkinson’s Disease

Chan

Tai

Wang

et al. 2023

Neurorehabil Neural Repair

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Background People with Parkinson’s disease (PD) are known to have motor learning difficulties. Although numerous studies have demonstrated that a single bout of aerobic exercise (AEX) can facilitate motor learning in non-disabled adults, the same beneficial effect in PD is unknown. Furthermore, associated neuroplastic changes have not been investigated. Objectives This study aimed to determine whether a single bout of aerobic exercise (AEX) can facilitate motor sequence learning in people with PD and to investigate the associated neurophysiological changes. Methods Thirty individuals with PD were recruited and randomized into the exercise group (PD + AEX) and non-exercise group (PD − AEX). At the first visit, corticomotor excitability was assessed using transcranial magnetic stimulation (TMS). All participants then performed a serial reaction time task (SRTT) followed by 20 minutes of moderately-high intensity aerobic exercise (AEX) for the PD + AEX group or rest for the PD − AEX group. The SRTT and TMS were reevaluated at 3 time points: immediately after aerobic exercise (AEX) or rest, on the second day after practice (D2), and a week after practice (D7). Results Both groups showed improvement throughout practice. At retention, the PD + AEX group showed improved SRTT performance on D7 compared to D2 ( P = .001), while the PD − AEX group showed no change in performance. TMS results showed that the PD + AEX group had significantly higher corticomotor excitability than the PD − AEX group on D7. Conclusion A single session of aerobic exercise (AEX) could enhance motor sequence learning and induce neuroplastic changes. Clinicians can consider providing aerobic exercise (AEX) after motor task training for people with PD. Clinical registration: NCT04189887 (ClinicalTrials.gov).

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“…Moreover, both DNAmPhenoAge acceleration and DNAmGrimAge acceleration showed that higher level of physical tness suppresses the progress of aging. The health promoting effects of exercise are well documented (Hortobágyi et al 2022;Quan et al 2020;Radak et al 2012), but this is the rst study, to our knowledge, which demonstrates that these changes are based on DNA methylation, hence could be inherited in a certain degree.…”

Section: Discussionmentioning

confidence: 81%

Association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

Seki

Aczel

Torma

et al. 2022

Preprint

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Cellular senescence is greatly accelerated by telomere shortening, and the steps forward in human aging is strongly influenced by environmental and life-style factors, whether DNA methylation (DNAm) is affected by exercise training, remains unclear. In the present study we investigated the relationships between physiological functions, maximal oxygen uptake (VO2max), vertical jump, working memory, telomere length (TL) assessed by RT-PCR, DNAmethylation based estimation of TL (DNAmTL) and DNA methylation based biomarkers of aging of master rowers (N = 151) and sedentary subjects (N = 90), aged between 37–85 years. It was found that the TL inversely correlated with chronological age, while no gender dependent difference was found. We could not detect association between telomere length and VO2max, vertical jump and working memory by RT-PCR method, while these physiological test results showed correlation with DNAmTL. DNAmGrimAge and DNAmPhenoAge acceleration were inversely associated with telomere length assessed by both methods. It appears that there is no powerful beneficial effects of exercise or physiological fitness on telomere shortening, however the degree of DNA methylation is associated with telomere length. DNAm based estimation of TL shows stronger relationships with physiological functions than RT-PCR measured data.

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The impact of aerobic and resistance training intensity on markers of neuroplasticity in health and disease

Cited by 33 publications

References 239 publications

No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

No strong association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

Influences of Aerobic Exercise on Motor Sequence Learning and Corticomotor Excitability in People With Parkinson’s Disease

Association among epigenetic modifications by DNA methylation, telomere length, and physical fitness in biological aging

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