The impact of aerobic and anaerobic training regimes on blood pressure in normotensive and hypertensive rats: focus on redox changes

Jakovljevic, Biljana; Turnic, Tamara Nikolic; Jeremić, Nevena; Jeremić, Jovana; Bradić, Jovana; Ravic, Marko; Jakovljević, Vladimir; Jelic, Djordje; Radovanović, Dragan; Pecháňová, Oľga; Živković, Vladimir

doi:10.1007/s11010-018-3457-y

Cited by 13 publications

(22 citation statements)

References 33 publications

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“…Results of our study clearly indicate that nimodipine, nicardipine, and training alone and their combination did significantly increased relative to the control normotensive group of rats [4]. The reason for different levels of O 2 after training might be the duration of exercise protocols.…”

Section: Discussionmentioning

confidence: 49%

“…Animals and Design of the Study. According to the literature data and our previous investigations [4], we used ninety-six male Wistar albino rats that were kept on an artificial 12-h light-dark cycle (8 : 00 am-8 : 00 pm) at room temperature (22 ± 2°C). Water and food were available ad libitum.…”

Section: Methodsmentioning

confidence: 99%

“…In our study, moderate-intensity training (MIT) was performed ( Figure 1 and Table 1). The rats on exercise MIT protocol ran on treadmill for 8 weeks-5 days, with 1 week of adaptation period before (8 m/s speed for 30 min/day), and with gradual increase in speed during weeks, from 10 m/min in the second week to 15 m/min in the eighth week with 3 min rest/100 m and 5 min warmup at 8 m/min, prior to each training session [4].…”

Section: Exercise Protocol Exercise Protocol Was Performed Bymentioning

confidence: 99%

“…Nowadays, scientists are engaged in finding the optimal intensity of physical activity in order to promote health and lifespan, improve quality of life, and decrease the incidence of lifestyle-related diseases [2,3]. Moderateintensity training (MIT) represents a training method involving longer-duration sessions of moderate-intensity exercise performed continuously without rest [4].…”

Section: Introductionmentioning

confidence: 99%

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Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats

Ristić

Folić

Radonjić

et al. 2020

Oxidative Medicine and Cellular Longevity

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Taken into consideration that oxidative stress response after preconditioning with phosphodiesterase inhibitors (PDEIs) and moderate physical activity has still not been clarified, the aim of this study was to assess the effects of PDEIs alone or in combination with physical activity, on systemic redox status. The study was carried out on 96 male Wistar albino rats classified into two groups. The first group included animals exposed only to pharmacological preconditioning (PreC) maneuver (sedentary control (CTRL, 1 ml/day saline, n=12), nicardipine (6 mg/kg/day of NIC, n=12), vinpocetine (10 mg/kg/day of VIN, n=12), and nimodipine (NIM 10 mg/kg/day of, n=12). The second included animals exposed to preconditioning with moderate-intensity training (MIT) on treadmill for 8 weeks. After 5 weeks from the start of training, the animals were divided into four subgroups depending on the medication to be used for pharmacological PreC: moderate-intensity training (MIT+ 1 ml/day saline, n=12), nicardipine (MIT+ 6 mg/kg/day of NIC, n=12), vinpocetine (MIT+ 10 mg/kg/day of VIN, n=12), and nimodipine (MIT+ 10 mg/kg/day of NIM, n=12). After three weeks of pharmacological preconditioning, the animals were sacrificed. The following oxidative stress parameters were measured spectrophotometrically: nitrites (NO2−), superoxide anion radical (O2−), hydrogen peroxide (H2O2), index of lipid peroxidation (TBARS), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH). Our results showed that PDE1 and MIT preconditioning decreased the release of prooxidants and improved the activity of antioxidant enzymes thus preventing systemic oxidative stress.

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Section: Discussionmentioning

confidence: 49%

Section: Methodsmentioning

confidence: 99%

Section: Exercise Protocol Exercise Protocol Was Performed Bymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats

Ristić

Folić

Radonjić

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Various types of exercise training are able to induce beneficial effects on the progression of subclinical atherosclerosis [140][141][142][143]. Regular physical activity not only improves clinical symptoms but also affects the progression of atherosclerosis by reducing the rupture of atherosclerotic plaque and enhancing the endothelial-related relaxation, which is protective against endothelial NOS (eNOS-NO) dysfunction in atherosclerosis [135,140,[144][145][146][147].…”

Section: Effect Of Exercise On Atherosclerosis and Oxidative Stressmentioning

confidence: 99%

Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining

et al. 2019

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Although low levels of reactive oxygen species (ROS) are beneficial for the organism ensuring normal cell and vascular function, the overproduction of ROS and increased oxidative stress levels play a significant role in the onset and progression of cardiovascular diseases (CVDs). This paper aims at providing a thorough review of the available literature investigating the effects of acute and chronic exercise training and detraining on redox regulation, in the context of CVDs. An acute bout of either cardiovascular or resistance exercise training induces a transient oxidative stress and inflammatory response accompanied by reduced antioxidant capacity and enhanced oxidative damage. There is evidence showing that these responses to exercise are proportional to exercise intensity and inversely related to an individual's physical conditioning status. However, when chronically performed, both types of exercise amplify the antioxidant defense mechanism, reduce oxidative stress and preserve redox status. On the other hand, detraining results in maladaptations within a time-frame that depends on the exercise training intensity and mode, as high-intensity training is superior to low-intensity and resistance training is superior to cardiovascular training in preserving exercise-induced adaptations during detraining periods. Collectively, these findings suggest that exercise training, either cardiovascular or resistance or even a combination of them, is a promising, safe and efficient tool in the prevention and treatment of CVDs.

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High‐intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

et al. 2021

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Background: The prostatic effects induced by arterial hypertension is very controversial and its mechanism is unclear. High-intensity interval training (HIIT) is an exercise considered to be hypotensive. The objective of this work was to investigate the molecular, biochemical, and morphological effects of 8 weeks of HIIT in the prostatic tissue of spontaneously hypertensive rats (SHR).Methods: Twenty male SHR rats, 51.4 weeks old, were used. The SHR animals were divided into two groups: spontaneously sedentary hypertensive and spontaneously hypertensive submitted to HIIT. We analyze androgens receptor and glucocorticoid receptors in the prostate. Still, we verify effects of the hypertension and HIIT on the physiopathology prostatic, for immunohistochemistry investigated BCL-2, BAX, IGF-1, FAS/CD95, data's inflammatory tumour necrosis factor α, nuclear factor kappa B and interleukin (IL)-6, anti-inflammatory IL-10. The echocardiographic evaluation was performed at the baseline and after the training period.Results: Arterial hypertension promote high prostatic intraepithelial neoplasia incidence in the prostate, increases IGF-1, BCL-2 (p < 0.05), and inflammatory proteins (p < 0.05). Eight weeks of HIIT training reduced the arterial pressure and increase the concentration of tissue collagen and intracellular glycogen and showed a higher expression of BAX, FAS/CD95, and IL-10 proteins (p < 0.05), coinciding with a lower incidence of lesions and lower prostate weight (p < 0.05) and reduction of the BCL-2 and IGF-1. Conclusion:Our data suggested that arterial hypertension suppressed apoptosis and increased damage prostatic. On other hand, HIIT promotes morphology and function improves in the prostatic environment, inhibited inflammation, and increased apoptosis.

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The impact of aerobic and anaerobic training regimes on blood pressure in normotensive and hypertensive rats: focus on redox changes

Cited by 13 publications

References 33 publications

Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats

Preconditioning with PDE1 Inhibitors and Moderate-Intensity Training Positively Affect Systemic Redox State of Rats

Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining

High‐intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate

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