The impact of adjuvant treatment with external beam radiotherapy and vaginal brachytherapy on health-related quality of life in patients with early-stage endometrioid endometrial carcinoma — initial results of a prospective study

Kluska, Adam; Moszyńska-Zielińska, Małgorzata; Zytko, Leszek; Tracz, Natalia; Tomasik, Bartłomiej; Stanisławek, Anna; Łuniewska-Bury, Jolanta; Fijuth, Jacek; Gottwald, Leszek

doi:10.5603/gp.a2021.0112

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2023

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“…Although the current medical science has been very advanced, the molecular mechanism of the occurrence of EC is not very clear [5]. Further exploration of the pathogenesis of EC and finding new targets for treatment are of vital significance for improving the prognosis of EC [6].…”

Section: Introductionmentioning

confidence: 99%

Chikusetsusaponin Iva induces apoptosis and inhibits proliferation in endometrial cancer via promoting reactive oxygen species (ROS) production

2023

European Journal of Gynaecological Oncology

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Endometrial carcinoma (EC) is an epithelial malignant tumor that occurs in the endometrium. It is of great significance to explore new targets for improving the prognosis of endometrial cancer. Chikusetsusaponin Iva (CHI) is a plant compound extracted from Panacis japonica which has multiple biological activities, including anti-inflammation and anti-tumor effects. However, its possible effects on EC are unclear. Herein, we found that CHI inhibited EC cell proliferation and cell cycle, confirmed by colony formation and flow cytometry (FCM) assays. The results further confirmed that CHI stimulated the apoptosis of EC cells. Furthermore, we noticed that CHI treatment induced reactive oxygen species (ROS) in EC cells. In addition, it could suppress the Microtubule-Associated Protein Kinase (MAPK) pathway in EC cells, thereby affecting cell proliferation and apoptosis. Therefore, CHI could serve as a potential drug for EC treatment.

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Section: Introductionmentioning

confidence: 99%

Chikusetsusaponin Iva induces apoptosis and inhibits proliferation in endometrial cancer via promoting reactive oxygen species (ROS) production

2023

European Journal of Gynaecological Oncology

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show abstract

The impact of adjuvant treatment with external beam radiotherapy and vaginal brachytherapy on health-related quality of life in patients with early-stage endometrioid endometrial carcinoma — initial results of a prospective study

Abstract: This article has been peer reviewed and published immediately upon acceptance.

Cited by 1 publication

References 17 publications

Chikusetsusaponin Iva induces apoptosis and inhibits proliferation in endometrial cancer via promoting reactive oxygen species (ROS) production

Chikusetsusaponin Iva induces apoptosis and inhibits proliferation in endometrial cancer via promoting reactive oxygen species (ROS) production

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