The impact of adipokines on vascular networks in adipose tissue

Vliora, Maria; Ravelli, Cosetta; Grillo, Elisabetta; Corsini, Michela; Andreas, D. Flouris; Mitola, Stefania

doi:10.1016/j.cytogfr.2022.07.008

Cited by 9 publications

(8 citation statements)

References 228 publications

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“…The plasticity and expansion of WAT are associated with its angiogenic capacity, which is necessary for the formation of new blood vessels during fat tissue expansion. To promote vascularization, growing adipocytes produce a variety of angiogenic factors, including vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF‐2), hepatocyte growth factor (HGF), insulin‐like growth factor (IGF), placental growth factor (PLGF), vascular endothelial growth factor C (VEGFC), heparin‐binding epidermal growth factor (HB‐EGF), and angiopoietin 73 …”

Section: Wat Microenvironment Remodeling and Metabolismmentioning

confidence: 99%

MHO or MUO? White adipose tissue remodeling

Zhao,

Zhou,

et al. 2024

Obesity Reviews

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SummaryIn this review, we delve into the intricate relationship between white adipose tissue (WAT) remodeling and metabolic aspects in obesity, with a specific focus on individuals with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). WAT is a highly heterogeneous, plastic, and dynamically secreting endocrine and immune organ. WAT remodeling plays a crucial role in metabolic health, involving expansion mode, microenvironment, phenotype, and distribution. In individuals with MHO, WAT remodeling is beneficial, reducing ectopic fat deposition and insulin resistance (IR) through mechanisms like increased adipocyte hyperplasia, anti‐inflammatory microenvironment, appropriate extracellular matrix (ECM) remodeling, appropriate vascularization, enhanced WAT browning, and subcutaneous adipose tissue (SWAT) deposition. Conversely, for those with MUO, WAT remodeling leads to ectopic fat deposition and IR, causing metabolic dysregulation. This process involves adipocyte hypertrophy, disrupted vascularization, heightened pro‐inflammatory microenvironment, enhanced brown adipose tissue (BAT) whitening, and accumulation of visceral adipose tissue (VWAT) deposition. The review underscores the pivotal importance of intervening in WAT remodeling to hinder the transition from MHO to MUO. This insight is valuable for tailoring personalized and effective management strategies for patients with obesity in clinical practice.

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Section: Wat Microenvironment Remodeling and Metabolismmentioning

confidence: 99%

MHO or MUO? White adipose tissue remodeling

Zhao,

Zhou,

et al. 2024

Obesity Reviews

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“…Indeed, a new set of studies have highlighted that the AT can be located near and surrounding most of large blood vessels, providing an important mechanical protection and modulating the vascular tone, density and angiogenic processes (Galley et al, 2022; Opatrilova et al, 2018; Vliora et al, 2023). Besides this direct contact between the AT and vascular tissue, a paracrine or endocrine communication mediated by the secretion of many adipokines regulates the vascular function.…”

Section: Cerebrovascular System Adipose Tissue and Alzheimer's Diseasementioning

confidence: 99%

“…The RAAS regulates blood osmolarity and pressure throughout the body and the AT modulates this system at several points, such as the production of angiotensinogen and by expressing aldosterone (Briones et al, 2012; Yasue et al, 2010). This critical communication between the AT and the vasculature can be altered under pathological conditions such as obesity or any other metabolic disorder, leading to the development of important negative effects that may cause many vascular abnormalities, including endothelial dysfunction, vascular stiffness and elevated blood pressure (Galley et al, 2022; Opatrilova et al, 2018; Vliora et al, 2023). Therefore, AT‐mediated vascular damage may be considered a therapeutic target not only for metabolic, but also for neurological diseases, such as AD.…”

Section: Cerebrovascular System Adipose Tissue and Alzheimer's Diseasementioning

confidence: 99%

“…Taking into consideration that vascular damage is an important feature of many neurodegenerative disorders, understanding the link(s) by which the AT may modify the vascular system and consequently promote brain disorders is a matter of great interest. Indeed, a new set of studies have highlighted that the AT can be located near and surrounding most of large blood vessels, providing an important mechanical protection and modulating the vascular tone, density and angiogenic processes (Galley et al, 2022;Opatrilova et al, 2018;Vliora et al, 2023). Besides this direct contact between the AT and vascular tissue, a paracrine or endocrine communication mediated by the secretion of many adipokines regulates the vascular function.…”

Section: Adipose Tissue and The Vascular Systemmentioning

confidence: 99%

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Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

Bettinetti‐Luque,

Trujillo‐Estrada,

Garcia‐Fuentes

et al. 2023

British J Pharmacology

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The adipose tissue (AT) has recently been recognized as an important endocrine organ that plays a crucial role in energy metabolism and in the immune response in multiple metabolic tissues. With this regard, emerging evidence indicates that an important crosstalk exists between the AT and the brain. However, the AT contribution in the development of age‐related diseases, including Alzheimer’s disease (AD), remains poorly defined. New studies suggest that the AT modulates brain function through multiple bioactive factors known as adipokines, which can cross the blood brain barrier (BBB) to reach the brain target‐areas or even regulate the BBB function. In this review, we discuss the effect of multiple adipokines in the BBB physiology, their contribution to the development of AD and their therapeutic potential.

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“…If energy intake is relatively higher than consumption, the amount and volume of adipose tissue increases, with an eventual corresponding increase in mass [ 2 ]. The main role of adipose tissue is to store energy in the body and secrete adipokines as an active endocrine organ [ 3 ]. However, dysregulation of lipid metabolism causes an increase in adipose tissue inflow to the liver and destroys the balance of lipid metabolism, thereby resulting in obesity-induced fatty liver.…”

Section: Introductionmentioning

confidence: 99%

Novel Plant Extract Ameliorates Metabolic Disorder through Activation of Brown Adipose Tissue in High-Fat Diet-Induced Obese Mice

Kim

Yang

Kwon

et al. 2022

IJMS

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Obesity is characterized by excessive body fat accumulation due to unbalanced energy intake and expenditure. Potential therapeutic targets for anti-obesity include the inhibition of white adipose tissue (WAT) hypertrophy and hyperplasia and the activation of brown adipose tissue (BAT). Not only the activation of BAT but also the browning of WAT have gained increasing attention in research fields as an alternative method in the prevention and treatment of obesity. Here, we investigated possible mechanisms underlying the anti-obesity effect of Phlomis umbrosa Turcz. root ethanol extract (PUE) in an obesogenic animal model. PUE treatment can reduce diet-induced obesity and modulate obesity-associated metabolic disorders, including insulin resistance, hepatic steatosis, and inflammation. In the liver, PUE improved hepatic steatosis by suppressing hepatic lipogenesis and lipid absorption while increasing biliary sterol excretion and hepatic fatty acid oxidation compared to the high-fat group. Moreover, PUE increased energy expenditure and regulated fecal lipid excretion, leading to reduced body weight gain. In particular, PUE remarkably activated the browning of subWAT via upregulation of the browning-related protein and gene expression and promoted BAT activation. In conclusion, these findings provide the potential therapeutic usefulness into the effects of PUE in the treatment of obesity and metabolic disorders. Furthermore, it suggests that PUE treatment can regulate energy metabolism via activating BAT and browning subWAT.

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The impact of adipokines on vascular networks in adipose tissue

Cited by 9 publications

References 228 publications

MHO or MUO? White adipose tissue remodeling

MHO or MUO? White adipose tissue remodeling

Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

Novel Plant Extract Ameliorates Metabolic Disorder through Activation of Brown Adipose Tissue in High-Fat Diet-Induced Obese Mice

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