The impact of acute mental stress on brachial artery flow-mediated dilation in women diagnosed with depression

D'Urzo, Katrina A; Rocque, Cherie L. La; Williams, Jennifer S.; Stuckless, Troy J.R.; King, Trevor J.; Plotnick, Meghan; Gurd, Brendon J.; Harkness, Kate L.; Pyke, Kyra E.

doi:10.1016/j.ijpsycho.2018.12.003

Cited by 9 publications

(7 citation statements)

References 45 publications

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“…This variation could be because individuals felt different intensities of shame at different times, altering the time course of change in the physiological correlates of shame and therefore the timing of their interaction with the endothelium. This idea is supported by reported variability in the time course of stress‐induced responses after an acute stress‐inducing task (Carson et al., 2017; Kario et al., 2002; Lopez‐Duran et al., 2009), which is why, similar to the primary analysis reported here, many studies characterize stress task reactivity as a peak change (Childs et al., 2010; D'Urzo et al., 2019; Dickerson & Kemeny, 2004; Lopez‐Duran et al., 2009; Sawyers et al., 2021). For example, Lopez‐Duran et al.…”

Section: Discussionsupporting

confidence: 79%

“…The %FMD and absFMD analysis was performed with and without covariation for SR‐AUC. This analysis strategy of capturing peak/nadir has been used previously in stress reactivity research (Carson et al., 2017; Childs et al., 2010; D'Urzo et al., 2019; Dickerson & Kemeny, 2004; Lopez‐Duran et al., 2009; Plotnick et al., 2017; Sawyers et al., 2021; Szijgyarto et al., 2013) and was used for this study to account for possible inter‐individual variability in the time course of physiological responses to shame. Substantial variability in individual time to peak has been noted for stress reactivity parameters in response to stress‐inducing protocols, such as the Trier social stress task (TSST) (Kirschbaum & Hellhammer, 2000; Lopez‐Duran et al., 2009).…”

Section: Methodsmentioning

confidence: 99%

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The acute effect of a laboratory shame induction protocol on endothelial function in young, healthy adults

McGarity-Shipley

Lew

Bonafiglia

et al. 2022

Experimental Physiology

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The objective of this study was to examine the impact of a shame induction protocol on endothelial function. Fifteen participants (n = 7 men, n = 8 women) completed both a written shame induction protocol and a control protocol on two different experimental days. Pre-and post-protocol we assessed: (1) endothelial function and arterial shear rate via a standard brachial artery reactive hyperaemia flow-mediated dilatation (FMD) test across two post-intervention time points (15 and 35 min post); (2) perceived shame via the experiential shame scale (ESS); and (3) cortisol and soluble tumor necrosis factor alpha receptor (sTNFαRII) through oral fluid analysis. Shame increased after the shame induction protocol (pre, 2.9 ± 0.6 vs. post, 3.7 ± 0.5, P < 0.001) but not the control protocol (pre, 3.0 ± 0.5 vs. post, 2.8 ± 0.5, P = 0.15; protocol by time interaction, P < 0.001). When all three time points were included in the analysis, %FMD did not change over time. Considering only the lowest post time point, %FMD decreased significantly in response to the shame protocol (pre, 4.8 ± 1.9 vs. post, 3.2 ± 1.6, P < 0.001) but not the control protocol (pre, 4.2 ± 1.8 vs. post, 3.8 ± 1.5, P = 0.45; protocol by time interaction, P = 0.035). Covariation of the shear rate stimulus for FMD did not alter the FMD results. When including both the control and shame protocols, but not the shame protocol alone, increased shame was significantly associated with decreased FMD (r = −0.37, P < 0.046). There were no significant time by protocol interaction effects for cortisol or sTNFαRII. In conclusion, temporary increases in shame might cause transient endothelial dysfunction which, if chronically repeated, could manifest as reduced vasoprotection against atherosclerosis.

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Section: Discussionsupporting

confidence: 79%

Section: Methodsmentioning

confidence: 99%

The acute effect of a laboratory shame induction protocol on endothelial function in young, healthy adults

McGarity-Shipley

Lew

Bonafiglia

et al. 2022

Experimental Physiology

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“…In the present study, there is no different in hemodynamics between groups. In addition, previous study (D'Urzo et al, 2019) demonstrated that mental stress does not affect the FMD. Thus, we believe that effect of acute smoking cessation may be minimal in the present study.…”

Section: Subjectsmentioning

confidence: 82%

Habitual cigarette smoking attenuates shear‐mediated dilation in the brachial artery but not in the carotid artery in young adults

et al. 2020

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In the present study, we hypothesized that habitual cigarette smoking attenuates endothelial function in the cerebral circulation as well as that of the peripheral circulation in young adults. To test this hypothesis, we measured cerebrovascular and peripheral flow‐mediated dilation (FMD) in young smokers and nonsmokers in the present study. Ten healthy nonsmokers and 10 smokers participated in the study. We measured blood velocity and diameter in the brachial artery and internal carotid artery (ICA) using Doppler ultrasound. We identified shear‐mediated dilation in the brachial artery and ICA by the percentage change in peak diameter during hyperemia stimulation (reactive hyperemia and hypercapnia). We measured the baseline diameter and the shear rate area under the curve from the onset of hyperemia to peak dilation in the brachial artery and ICA, finding the measurements of the smokers and those of the nonsmokers did not differ (p > .05). In contrast to brachial FMD (5.07 ± 1.79% vs. 7.92 ± 3.01%; smokers vs. nonsmokers, p = .019), FMD in the ICA was not attenuated in the smokers compared with that of the nonsmokers (5.46 ± 2.32% vs. 4.57 ± 2.70%; p = .442). These findings indicate that in young healthy smokers, cerebral endothelial function was preserved, and the response of cerebral endothelial function to smoking was different from that of peripheral vasculature.

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“…Brachial artery 47 [19,189,185,201,182,199,186,157,193,183,164,158,184,165,190,205,191,166,159,175,170,176,179,171,194,200,202,187,180,160,196,197,161,206,198,203,167,162,168,169,163,192,172,173,177,174,178] Femoral artery 2 [195,188] Posterior tibial artery 1 [204] Aspect of vasculature assessed Endothelial function 45…”

Section: Vascular Bed Assessedmentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

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The impact of acute mental stress on brachial artery flow-mediated dilation in women diagnosed with depression

Cited by 9 publications

References 45 publications

The acute effect of a laboratory shame induction protocol on endothelial function in young, healthy adults

The acute effect of a laboratory shame induction protocol on endothelial function in young, healthy adults

Habitual cigarette smoking attenuates shear‐mediated dilation in the brachial artery but not in the carotid artery in young adults

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

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