The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study

Burger, Antoinette; Brooks, Samantha J.; Stein, Dan J.; Howells, Fleur M.

doi:10.1016/j.drugalcdep.2017.11.029

Cited by 21 publications

(14 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first finding of the present study is that the NAA/PCr+Cr ratio was increased in the mPFC of MAD subjects. Finding the decreased ratio of NAA/PCr+Cr among MAD subjects is consistent with previous studies ( 12 , 16 , 18 , 39 , 40 ) and as well as other psychiatric disorders ( 41 ). NAA is taken as a neuronal marker, and reflects neuronal integrity, viability and number ( 42 ).…”

Section: Discussionsupporting

confidence: 92%

Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study

Chang

Long

et al. 2018

Front. Psychiatry

View full text Add to dashboard Cite

Background: The medial prefrontal cortex (mPFC) contains various neurotransmitter systems and plays an important role in drug use. Broad body of literature on how methamphetamine (MA) affects the structure and metabolism in the animal's mPFC is emerging, while the effects on metabolites of mPFC among human is still unclear. In this study, proton magnetic resonance spectroscopy (1H MRS) was used to measure metabolites of mPFC in methamphetamine dependent subjects.Methods: Sixty-one subjects with a history of MA dependence (fulfiled the Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria) and 65 drug-naïve control subjects (age19–45) completed 1H MRS scans using 3.0T Siemens MRI scanner. Single voxel spectra were acquired from the mPFC bilaterally using a point resolved spectroscopy sequence (PRESS). The 1H MRS data were automatically fit with linear combination model for quantification of metabolite levels of n-acetyl-aspartate (NAA), myo-inositol (mI), glycerophosphocholine plus phosphocholine(GPC+PC), phosphocreatine plus creatine (PCr+Cr), and glutamate (Glu). Metabolite levels were reported as ratios to PCr+Cr.Results: The MA group showed a significant reduction in NAA/PCr+Cr ratio and elevation in Glu/PCr+Cr ratio and mI/PCr+Cr ratio, compared with healthy control. No significant correlation was found between metabolite ratios and MA use variables.Conclusions: MA use is associated with a significant increased Glu/PCr+Cr ratio, mI/PCr+Cr ratio and reduced NAA/PCr+Cr ratio in the mPFC of MA dependence subjects. These findings suggest that Glu may play a key role in MA induced neurotoxicity.

show abstract

Section: Discussionsupporting

confidence: 92%

Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study

Chang

Long

et al. 2018

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…Across studies, subjects were imaged at various stages of substance use ranging from active use to ~2 years abstinent. Nine studies found myo- inositol levels were higher among methamphetamine and MDMA users relative to controls [124, 190-197], while 10 studies found no difference between groups [198-208]. Among studies that reported group differences, higher myo- inositol levels were most reliably observed in the frontal cortex [124, 190-197].…”

Section: Resultsmentioning

confidence: 99%

“…Nine studies found myo- inositol levels were higher among methamphetamine and MDMA users relative to controls [124, 190-197], while 10 studies found no difference between groups [198-208]. Among studies that reported group differences, higher myo- inositol levels were most reliably observed in the frontal cortex [124, 190-197]. Among studies that did not report a difference, methamphetamine/MDMA subjects tended to use less frequently than those reporting group differences [198, 201, 202, 204, 207].…”

Section: Resultsmentioning

confidence: 99%

Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

et al. 2019

View full text Add to dashboard Cite

There is tremendous interest in the role of the neuroimmune system and inflammatory processes in substance use disorders (SUDs). Imaging biomarkers of the neuroimmune system in vivo provide a vital translational bridge between preclinical and clinical research. Herein, we examine two imaging techniques that measure putative indices of the neuroimmune system and review their application among SUDs. Positron emission tomography (PET) imaging of 18 kDa translocator protein availability is a marker associated with microglia. Proton magnetic resonance spectroscopy quantification of myo-inositol levels is a putative glial marker found in astrocytes. Neuroinflammatory responses are initiated and maintained by microglia and astrocytes, and thus represent important imaging markers. The goal of this review is to summarize neuroimaging findings from the substance use literature that report data using these markers and discuss possible mechanisms of action. The extant literature indicates abused substances exert diverse and complex neuroimmune effects. Moreover, drug effects may change across addiction stages, i.e. the neuroimmune effects of acute drug administration may differ from chronic use. This burgeoning field has considerable potential to improve our understanding and treatment of SUDs. Future research is needed to determine how targeting the neuroimmune system may improve treatment outcomes.

show abstract

“…Such reduction is mediated by the redistribution of DA from vesicular storage vesicles to the extracellular space, the subsequent formation of reactive oxygen species and quinine by-products [163], and the lipid peroxidation of dopaminergic terminal membranes [164]. Alternatively, a recent study utilizing proton magnetic resonance spectroscopy compared METH users to healthy controls and demonstrated that after acute to short term abstinence, METH users display prominent damage of integrity in neuronal tissues, suggestive of maintained neuroinflammation in the PFC and anterior cingulate cortex [165].…”

Section: Inflammationmentioning

confidence: 99%

Traumatic brain injury and methamphetamine: A double-hit neurological insult

Hayek

Allouch²,

Razafsha

et al. 2020

Journal of the Neurological Sciences

View full text Add to dashboard Cite

The impact of acute and short-term methamphetamine abstinence on brain metabolites: A proton magnetic resonance spectroscopy chemical shift imaging study

Cited by 21 publications

References 79 publications

Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study

Metabolites Alterations in the Medial Prefrontal Cortex of Methamphetamine Users in Abstinence: A 1H MRS Study

Imaging Biomarkers of the Neuroimmune System among Substance Use Disorders: A Systematic Review

Traumatic brain injury and methamphetamine: A double-hit neurological insult

Contact Info

Product

Resources

About