The Impact of Accepting Living Kidney Donors With Mild Hypertension or Proteinuria on Transplantation Rates

Karpinski, Martin; Knoll, Greg; Cohn, Adam; Yang, Robert C.; Garg, Amit X.; Storsley, Leroy

doi:10.1053/j.ajkd.2005.10.012

Cited by 44 publications

(28 citation statements)

References 33 publications

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“…We should recognize that the use of marginal living donors as a response to the growing number of patients who have ESRD and are dying while awaiting renal transplantation may be in direct conflict with our responsibility to potential donors to "do no harm." A recent multicenter study of potential living donors in Canada found that acceptance of potential donors who were excluded for mild hypertension or proteinuria would have resulted in only a 3% increase in the number of patients who receive a transplant (82). Liberalization of these exclusion criteria would have a minimal impact on the waiting list and would not offset its steady growth.…”

Section: Discussionmentioning

confidence: 99%

Medical Risks in Living Kidney Donors

Ommen¹,

Winston²,

Murphy³

2006

Clinical Journal of the American Society of Nephrology

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Section: Discussionmentioning

confidence: 99%

Medical Risks in Living Kidney Donors

Ommen¹,

Winston²,

Murphy³

2006

Clinical Journal of the American Society of Nephrology

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“…It is impossible to calculate the precise number of patients awaiting a cadaver organ that could be taken off the wait list if use of donors with kidney stones became standard practice. Karpinski et al [30] recently explored the impact of using ‘marginal’ living donors with mild hypertension or proteinuria. They found a potential modest increase of donors of 3%.…”

Section: Discussionmentioning

confidence: 99%

Trends in Kidney Donation among Kidney Stone Formers: A Survey of US Transplant Centers

et al. 2009

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Background: Living kidney donation is on the rise and acceptance criteria for potential donors are evolving to include more ‘complex’ patients such as kidney stone formers. Transplant centers are faced with sparse data on patient outcomes when evaluating potential donors who are stone formers; thus, attitudes and practice can differ greatly between centers. Methods: We conducted a survey of United States kidney transplant programs to assess current trends in the approach to dealing with stone formers who are evaluated for kidney donation. Results: Based on the survey results, there appears to be a tendency toward increased acceptance of donors with a history of kidney stones. 77% of responding centers allowed stone formers to donate. Nearly 40% of centers reported that their attitude towards accepting donors with kidney stones has changed over the last 5–10 years. Among these, the overwhelming majority reported that they were more likely to accept these donors. Conclusions: Such trends are likely based on organ need, as published patient outcomes and evidence-based guidelines are lacking for this unique group of patients. We propose the need for a study to formally evaluate the outcome of stone formers who donate a kidney in order to systematically examine whether appropriately selected stone formers can safely donate.

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“…This was found to be due to circulating donor-specific antibodies (ABO or HLA) on immunologic screening of the recipient [71]. Medical professionals and governments have realized this fact and have undertaken different approaches to increase transplantation rates through living donation [72,73].…”

Section: Policies To Enhance Living Donationmentioning

confidence: 99%

Live Donor Kidney Transplantation Pearls: A Practical Review

Matter¹,

Abbas²,

Nagib³

et al. 2017

UNOAJ

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Living donation is "a gift of extraordinary value". The use of living donors for renal transplantation was critical for the early development of the field and preceded the use of cadaveric donors. Most donors are related genetically to the recipient, but there are an increasing percentage of cases, where donors are genetically unrelated like spouses, friends, or other emotionally related individuals. Ethical guidelines mandate that the living donors should not be coerced without any evidence of financial profit for the donor. Living donation has been associated with a higher success rate than that seen with cadaveric donation. Conclusion:In view of higher demand for transplantation and the lack of a parallel increase in the number of available cadaveric organs, living donation is important solution for patients to avoid long times on waiting list, and occasionally, even the need of dialysis so, much efforts are needed to encourage living donation rates.

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The Impact of Accepting Living Kidney Donors With Mild Hypertension or Proteinuria on Transplantation Rates

Cited by 44 publications

References 33 publications

Medical Risks in Living Kidney Donors

Medical Risks in Living Kidney Donors

Trends in Kidney Donation among Kidney Stone Formers: A Survey of US Transplant Centers

Live Donor Kidney Transplantation Pearls: A Practical Review

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