The impact of a poor quality embryo on the implantation chance of a good quality one when transferred together: A study on double blastocyst transfers

Demirel, Cem; Çelik, Hale Göksever; Tülek, Fırat; Tuysuz, Gulsum; Donmez, Ersan; Ergin, Tolga; Buyru, Faruk; Baştu, Ercan

doi:10.1016/j.jogoh.2020.101967

Cited by 5 publications

(2 citation statements)

References 19 publications

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“…Two other researchers also investigated the issue, and both confirmed that low-and high-quality embryo transfer could reduce implantation and fertility rates. However, these researchers did not report any differences in terms of clinical pregnancy rates, live birth rates, abortion rates, abnormal pregnancy rates, or multiple pregnancies, which is consistent with the current findings (15,16).…”

Section: Discussionsupporting

confidence: 87%

Evaluation of Fertility Success Rate with Simultaneous Transfer of Embryos with Different Qualities in IVF/ICSI Candidates

et al. 2022

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Background: One of the most important factors in the success of assisted reproductive techniques is the quality of the embryo generated in the laboratory. Whether to transfer only one high-quality embryo or a combination of high- and low-quality embryos is a dilemma. Objectives: The present study reviewed the embryo transfer records of IVF/intra cytoplasmic sperm injection (ICSI) patients in Dezful Infertility Center, Iran, to evaluate the impact of the simultaneous transfer of a low-quality embryo on the growth and implantation of a high-quality embryo and live birth. Methods: This cross-sectional study evaluated the files and records of 802 patients undergoing IVF/ICSI at Dezful Infertility Treatment Center from 2013 to September 2020. The patients were classified into group 1: Patients with the transfer of only one grade A (equal blastomeres without fragmentation) embryo, group 2: Patients with the transfer of two grade A and B (equal blastomeres with slight fragmentation) embryos, group 3: Patients with the transfer of two grade A and C (unequal blastomeres with or without fragmentation) embryos, and group 4: Patients with the transfer of two grade C and B embryos. Results: The mean age of women and men was 32.52 ± 5.10 and 37.59 ± 6.60 years, respectively. Age, duration of infertility, cause of infertility, endometrial diameter, estradiol level, oocyte number, and embryo number had no significant differences between the groups (P > 0.05). Also, the findings indicated no significant differences between the groups in terms of implantation rate, live birth rate, fertility rate, multiple pregnancies rate, and chemical and clinical abortions (P > 0.05). Conclusions: It seems that the simultaneous transfer of embryos with different qualities does not affect the success rate and fertility outcomes in IVF/ICSI candidates.

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Section: Discussionsupporting

confidence: 87%

Evaluation of Fertility Success Rate with Simultaneous Transfer of Embryos with Different Qualities in IVF/ICSI Candidates

et al. 2022

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“…According to a study, SET can greatly decrease multiple pregnancy (MP) rates from 26−29% to 2%, and results in lower risks of miscarriage, preterm delivery, morbidity, and mortality of mothers and children (1). Many studies have shown that the risk of live birth is lower in the SET cycle than in the DET cycle (2)(3)(4). According to systematic reviews which included five randomized trials on pregnancy outcomes of SET and DET in fresh IVF cycle, the live birth rate (LBR) per cycle with DET was significantly higher than that with SET (OR: 2.10, 95% CI: 1.65 to 2.66), with MP rate being significantly lower in women who had SET compared with DET (OR: 0.04, 95% CI: 0.01-0.11) (5).…”

Section: Introductionmentioning

confidence: 99%

Association between transferred embryos and multiple pregnancy/live birth rate in frozen embryo transfer cycles: A retrospective study

Zhou²,

Xu³

et al. 2023

Front. Endocrinol.

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BackgroundPhysicians need an appropriate embryo transfer strategy to address the challenge of reducing multiple birth rates, while maintaining the couples’ live birth rate during assisted reproductive technology.MethodsWe included 10,060 frozen embryo transfer cycles from January 2015 to March 2020 in reproductive medical center of Ruijin hospital, Shanghai, China. Patients were grouped according to the number and grade of cleavage-stage embryo or blastocysts transferred. Live birth rate and multiple live birth rate were compared among groups of women of different ages. Multivariable logistic regression models were used to estimate the risk of multiple live birth using different combinations of transferred embryos.ResultsThe transfer of double good-quality embryos was an independent predictor for multiple birth in women aged <30 years and those aged 36−39 years [<30 years: aOR =1.54 (95% CI: 1.14−2.06, P < 0.01); 36−39 years: aOR =1.84 (95% CI: 1.0−3.4, P < 0.01)]. Further, for women aged <36 years, the transfer of good-quality + poor-quality blastocysts was an independent predictor for multiple birth rate [<30 years: aOR=2.46 (95% CI: 1.45−4.18, P < 0.01); 31−35 years: aOR =4.45 (95% CI: 1.97−10.06, P < 0.01)].ConclusionsSingle-good-quality blastocyst transfer is recommended for women of all ages. When good-quality cleavage embryos are available, the choice of single or double embryo transfer with good- or average-quality embryo should depend on the age of women. Double embryo transfer with the highest possible grade of embryos is recommended for women aged ≥40 years.

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Transfer of a poor-quality along with a good-quality embryo on in vitro fertilization/intracytoplasmic sperm injection-embryo transfer clinical outcomes: a systematic review and meta-analysis

Xiao¹,

Wang²,

Gui³

et al. 2022

Fertility and Sterility

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The impact of a poor quality embryo on the implantation chance of a good quality one when transferred together: A study on double blastocyst transfers

Cited by 5 publications

References 19 publications

Evaluation of Fertility Success Rate with Simultaneous Transfer of Embryos with Different Qualities in IVF/ICSI Candidates

Evaluation of Fertility Success Rate with Simultaneous Transfer of Embryos with Different Qualities in IVF/ICSI Candidates

Association between transferred embryos and multiple pregnancy/live birth rate in frozen embryo transfer cycles: A retrospective study

Transfer of a poor-quality along with a good-quality embryo on in vitro fertilization/intracytoplasmic sperm injection-embryo transfer clinical outcomes: a systematic review and meta-analysis

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