The impact of a human influenza pandemic

Booth, Sarah

doi:10.1111/j.1365-2044.2006.04553.x

Cited by 3 publications

(1 citation statement)

References 2 publications

(2 reference statements)

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“…It is worrisome that published evidence suggests that, at present, pandemic preparations are limited. 5,6 This lack of preparation may be either because of a lack of awareness of the need for preparation, or the unwillingness of decision makers to commit expensive resources in the presence of so much uncertainty. Of course, the exact nature, timing, and severity of the next pandemic is impossible to predict with accuracy and there is even considerable controversy as to whether the world can expect an imminent event.…”

Section: Introductionmentioning

confidence: 98%

SARS, Bird Flu and other scares—epidemic and pandemic preparedness in intensive care

Joynt

Gomersall

2008

Southern African Journal of Anaesthesia and Analgesia

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Section: Introductionmentioning

confidence: 98%

SARS, Bird Flu and other scares—epidemic and pandemic preparedness in intensive care

Joynt

Gomersall

2008

Southern African Journal of Anaesthesia and Analgesia

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Pandemic preparedness

Gomersall¹,

Loo²,

Joynt³

et al. 2007

Current Opinion in Critical Care

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THE EFFICACY OF INTRACOELOMIC FOSPROPOFOL IN RED-EARED SLIDERS (TRACHEMYS SCRIPTA ELEGANS)

Schroeder

Johnson

2013

Journal of Zoo and Wildlife Medicine

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Intravenous anesthetic delivery in reptiles can be challenging; current injectable techniques have varied induction/recovery times and anesthetic quality. This study hypothesized that intracoelomic administration of a new anesthetic, fospropofol, in turtles would result in dose-dependent anesthesia and respiratory depression. A two-part prospective trial using adult red-eared slider turtles (Trachemys scripta) weighing 764±17 g was conducted to 1) determine an effective anesthetic dose, and 2) evaluate the anesthetic quality, duration and respiratory effects of an efficacious dose. In Part 1, six turtles were randomly administered 25 mg kg−1 (low dose: LD) and 50 mg kg−1 (high dose: HD) fospropofol in a cross-over design. Respiratory rate, immobility and muscle relaxation scores were evaluated for 180 minutes. In Part 2, eight turtles were administered HD fospropofol. Immobility and muscle relaxation (front and hind limb) scores, and time to endotracheal intubation/extubation were evaluated until scores returned to baseline. In Part 1, the LD group had significantly lower immobility and muscle relaxation scores versus the HD group over time (both P<0.05); scores were significantly elevated from baseline for 20–120 minutes and 15–180 minutes, respectively (all P<0.05). Although not significantly different between groups (P>0.05), respiratory rate was significantly decreased from baseline from 10–120 minutes (all P<0.05). In Part 2, HD fospropofol decreased respiratory rate from 21.5±2.9 breaths min−1 to 0.1±0.1 breaths min−1, similar to the results in Part 1. Maximal reductions in immobility, front and hind limb motor tone occurred at 39.0±4.1, 30.8±3.6, and 24.0±3.6 minutes, respectively. Intubation in 7/8 turtles occurred at 45.7±5.4 min and extubation at 147.0±23.2 min. However, 2/8 turtles showed prolonged anesthetic effects, requiring resuscitative efforts for recovery. Due to the unpredictable quality and duration of anesthesia with intracoelomic fospropofol, it should be used with caution for general anesthesia in red-eared sliders at the doses and administration route investigated.

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The impact of a human influenza pandemic

Cited by 3 publications

References 2 publications

SARS, Bird Flu and other scares—epidemic and pandemic preparedness in intensive care

SARS, Bird Flu and other scares—epidemic and pandemic preparedness in intensive care

Pandemic preparedness

THE EFFICACY OF INTRACOELOMIC FOSPROPOFOL IN RED-EARED SLIDERS (TRACHEMYS SCRIPTA ELEGANS)

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