The Impact of 68Ga-PSMA PET/CT and PET/MRI on the Management of Prostate Cancer

PSA and PSA Kinetics Thresholds for the Presence of 68Ga-PSMA-11 PET/CT-Detectable Lesions in Patients with Biochemical Recurrent Prostate Cancer

“…A high positivity rate of 77% (450/581 patients) for the detection of malignant prostatic lesions was shown ( Figure 4A,B)). Our data reflects the positive results of several other studies and confirms that 68 Ga-PSMA-11 PET/CT is a promising method for diagnosing PC [12,[20][21][22][23][24]. For restaging prostatectomized BC patients by PSMA PET/CT, the EAU guidelines recommend a PSA level of > 0.2 ng/mL [8].…”

“…In the group of prostatectomized patients, the positivity rate was 75% (370/493 patients) (see Table 3A). Therefore, a clinically relevant percentage of patients with low PSA levels (< 0.5 ng/mL) could be diagnosed with the recurrence of PC, being comparable to the results of other studies [6,12,23,26]. In recent studies of restaging by 68 Ga-PSMA PET/CT, the detection rate was 50% at PSA levels of 0.2 to 0.49 ng/mL [6] and, in another study, 57.9% of the patients were 68 Ga-PSMA PET/CT-positive at PSA levels from 0.2 to < 0.5 ng/mL [20].…”

“…In recent studies of restaging by 68 Ga-PSMA PET/CT, the detection rate was 50% at PSA levels of 0.2 to 0.49 ng/mL [6] and, in another study, 57.9% of the patients were 68 Ga-PSMA PET/CT-positive at PSA levels from 0.2 to < 0.5 ng/mL [20]. The results from the present study emphasize that 68 Ga-PSMA PET/CT is a sensitive tool for restaging PC, even at low PSA values [23]. After early salvage RT (PSA ≤ 0.5 ng/mL), an undetectable PSA level can be reached in 60% of the patients, being associated with a chance of 80% for a progression free five-year survival.…”

“…Eiber et al described that the detection of malignant lesions by PET was extremely important for the final diagnosis in over 50%. They showed lesions that were not detected by computed tomography (CT) [20,23]. Another study demonstrated that, in patients with BC after RP while using the standard procedure, nearly 20% of 68 Ga-PSMA PET/CT-positive lesions-suspicious of malignancy-would not have been included in the radiation field.…”

“…All of these patients belonged to the crucial collective with PSA of < 1 ng/mL. 68 Ga-PSMA-11 PET/CT hybrid imaging opens up the possibility of changing the therapy [23,27]. Based on the data, both radiation therapists and urologists should have a more accurate road map for directing therapy.…”