The impact of 3-D virtual hepatectomy simulation in living-donor liver transplantation

Yamanaka, Junichi; Saito, Shinichi; Iimuro, Yuji; Hirano, Toshio; Okada, Toshihiro; Kuroda, N.; Sugimoto, Takafumi; Fujimoto, Jiro

doi:10.1007/s00534-005-1075-z

Cited by 31 publications

(35 citation statements)

References 18 publications

(39 reference statements)

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“…Liver scintigraphy has been used to evaluate the functional liver reserve, and evaluation of the separated liver area is possible using this method (7). Liver volume represents another piece of useful information to define operative indications and is usually measured by computed tomography (CT) (4)(5)(6)(8)(9)(10). In cases of PVE, both the morphological liver volume and functional liver volume may change before and after embolization.…”

Section: Resultsmentioning

confidence: 99%

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Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Nanashima¹,

Abo²,

Kudo

et al. 2013

Nuclear Medicine Communications

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ObjectivesThe aim of the study was to clarify the clinical significance of single-photon emission computed tomography/computed tomography (SPECT/CT) imaging in terms of technetium-99m galactosyl human serum albumin ( 99m Tc-GSA) scintigraphy. To this end, we examined the relationship using data from surgical records of 67 patients with hepatocellular carcinoma who underwent hepatectomy. Materials and methodsLiver functional parameters or functional volume was estimated by 99m Tc-GSA scintigraphy and computed tomography volumetry was used to estimate morphological volume. ResultsLiver uptake ratio at 15 min (LHL15) was correlated with the indocyanine green retention rate at 15 min (ICGR15; R=−0.608, P<0.01); however, five patients (7.5%) had values outside this correlation.In these patients, LHL15 reflected clinical status and patient outcomes more. Although morphological and functional volumes were well correlated (P<0.01), functional volume was decreased in the diseased liver with portal vein tumor thrombus or portal vein embolization. By applying ConclusionUnder the ICGR15 test as the standard for preoperative hepatic function, auxiliary application of LHL15 and functional volumetry provides useful information on hepatocellular carcinoma patients undergoing hepatectomy.

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Section: Resultsmentioning

confidence: 99%

“…Further, segmental liver volume varies remarkably in some cases (6). Regardless of PVE, ICG test results are unimproved, even if the embolized hemiliver is remarkably diseased and functional volume is decreased (4).…”

Section: Resultsmentioning

confidence: 99%

Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Nanashima¹,

Abo²,

Kudo

et al. 2013

Nuclear Medicine Communications

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“…Several software programs currently used were developed to analyze detailed 3D vasculature and bile duct structure as well as to predict liver resection volume. [2][3][4][5] In this manuscript, we review recent advances and clinical applications of 3D images of pulmonary vessels and the tracheobronchial tree.…”

Section: Introductionmentioning

confidence: 99%

Three Dimensional Computed Tomography Lung Modeling is Useful in Simulation and Navigation of Lung Cancer Surgery

Ikeda

Yoshimura

Hagiwara

et al. 2013

Ann Thorac Cardiovasc Surg

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The number of minimally invasive operations, such as video-assisted thoracoscopic surgery (VATS) lobectomy or segmentectomy, has enormously increased in recent years. These operations require extreme knowledge of the anatomy of pulmonary vessels and bronchi in each patient, and surgeons must carefully dissect the branches of pulmonary vessels during operation. Thus, foreknowledge of the anatomy of each patient would greatly contribute to the safety and accuracy of the operation. The development of multi-detector computed tomography (MDCT) has promoted three dimensional (3D) images of lung structures. It is possible to see the vascular and bronchial structures from the view of the operator; therefore, it is employed for preoperative simulation as well as navigation during operation. Due to advances in software, even small vessels can be accurately imaged, which is useful in performing segmentectomy. Surgical simulation and navigation systems based on high quality 3D lung modeling, including vascular and bronchial structures, can be used routinely to enhance the safety operation, education of junior staff, as well as providing a greater sense of security to the operators.

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“…Some other studies were focused on virtual planning and modeling of LDLT procedures [27], [28]. Yamanaka et al [27] developed software to virtually predict graft volumes and corresponding drainage volumes based on CT images.…”

Section: Introductionmentioning

confidence: 99%

Modeling the Impact of Partial Hepatectomy on the Hepatic Hemodynamics Using a Rat Model

Debbaut

Wilde

Casteleyn

et al. 2012

IEEE Trans. Biomed. Eng.

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Due to the growing shortage of donor livers, more patients are waiting for transplantation. Living donor liver transplantation may help expanding the donor pool, but is often confronted with the small-for-size syndrome. Since the hemodynamic effects of partial hepatectomy are not fully understood, we developed an electrical rat liver model to compare normal with resected liver hemodynamics. Detailed geometrical data and 3-D reconstructions of the liver vasculature of two rats were gathered by combining vascular corrosion casting, micro-CT scanning, and image processing. Data extrapolations allowed obtaining a total liver pressure- and flow-driven electrical analog. Subsequently, virtual resections led to 70%, 80%, or 90% partial hepatectomy models. Results demonstrated hyperperfusion effects such as portal hypertension and elevated lobe-specific portal venous flows (11, 12, and 24 mmHg, and 1.0-3.0, 1.8-3.5, and 7.4 ml/min for 70%, 80%, and 90% hepatectomy, respectively). Comparison of two 90% resection techniques demonstrated different total arterial flows (0.28 ml/min versus 0.61 ml/min), portal (24 mmHg versus 21 mmHg), and sinusoidal pressures (14 mmHg versus 9.5-12 mmHg), probably leading to better survival for lower portal and sinusoidal pressures. Toward the future, the models may be extrapolated to human livers and help us to optimize hepatectomy planning.

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The impact of 3-D virtual hepatectomy simulation in living-donor liver transplantation

Abstract: This hepatectomy simulation software reliably predicted accurate liver graft volume and the drainage volume of hepatic vein branches. This software may contribute to the preoperative planning of safe donor hepatectomy and implantation with satisfactory graft viability.

Cited by 31 publications

References 18 publications

Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Usefulness of examining hepatic functional volume using technetium-99m galactosyl serum albumin scintigraphy in hepatocellular carcinoma

Three Dimensional Computed Tomography Lung Modeling is Useful in Simulation and Navigation of Lung Cancer Surgery

Modeling the Impact of Partial Hepatectomy on the Hepatic Hemodynamics Using a Rat Model

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