The Impact of 3:1 Ketogenic Diet on Cardiac Repolarization Changes in Children with Refractory Seizures: A Prospective Follow-Up Study

Özdemir, Rahmi; Güzel, Orkide; Küçük, Mehmet; Karadeniz, Cem; Yılmaz, Ünsal; Çalık, Tansel; Meşe, Timur

doi:10.1055/s-0036-1582139

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…Magnesium depletion, likely from the low magnesium content of the KD, can also cause long QTcs and responds to magnesium replacement [ 89 ]. Increased magnesium content is one benefit of more liberal diets, like the MAD, which allow non-starch green vegetables Prospective studies on the controversial topic have been published finding the corrected QT interval did not change significantly over a 12-month period [ 91 , 92 ].…”

Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of a Ketogenic Diet in Children and Adolescents with Refractory Epilepsy—A Review

et al. 2020

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Epilepsy in the pediatric and adolescent populations is a devastating condition where individuals are prone to recurrent epileptic seizures or changes in behavior or movement that is the direct result of a primary change in the electrical activity in the brain. Although many children with epilepsy will have seizures controlled with antiseizure medications (ASMs), a large percentage of patients are refractory to drug therapy and may consider initiating a ketogenic diet. The term Ketogenic Diet or Ketogenic Diet Therapy (KDT) refers to any diet therapy in which dietary composition results in a ketogenic state of human metabolism. Currently, there are 4 major Ketogenic diet therapies—the classic ketogenic diet (cKD), the modified Atkins diet (MAD), the medium chain triglyceride ketogenic diet (MCTKD) and the low glycemic index treatment (LGIT). The compositions of the 4 main KDTs differ and limited evidence to distinguish the efficacy among different diets currently exists. Although it is apparent that more randomized controlled trials (RCTs) and long-term studies are needed to evaluate efficacy, side effects and individual response to the diet, it is imperative to study and understand the metabolic profiles of patients with epilepsy in order to isolate which dietary restrictions are necessary to maximize clinical benefit.

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Section: Resultsmentioning

confidence: 99%

Efficacy and Safety of a Ketogenic Diet in Children and Adolescents with Refractory Epilepsy—A Review

et al. 2020

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“…Specifically, a direct correlation was observed between QT interval prolongation and β-hydroxybutyrate concentrations, and between QT interval prolongation and systemic acidosis [ 60 ]. Interestingly, in a study of 70 children with drug-resistance epilepsy, receiving a ketogenic diet for a 12-month period, no deleterious effects on corrected QT interval, QT dispersion, and Tp-e interval were reported [ 61 ]. Finally, another case described a five-year-old boy who developed selenium deficiency, acute reversible cardiomyopathy and ventricular tachycardia with prolonged QT interval after following a ketogenic diet to treat refractory epilepsy.…”

Section: Sudden Cardiac Death and Qt Prolongation Triggered By Ketogenic Dietmentioning

confidence: 99%

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

et al. 2021

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A healthy regime is fundamental for the prevention of cardiovascular diseases (CVD). In inherited channelopathies, such as Brugada syndrome (BrS) and Long QT syndrome (LQTS), unfortunately, sudden cardiac death could be the first sign for patients affected by these syndromes. Several known factors are used to stratify the risk of developing cardiac arrhythmias, although none are determinative. The risk factors can be affected by adjusting lifestyle habits, such as a particular diet, impacting the risk of arrhythmogenic events and mortality. To date, the importance of understanding the relationship between diet and inherited channelopathies has been underrated. Therefore, we describe herein the effects of dietary factors on the development of arrhythmia in patients affected by BrS and LQTS. Modifying the diet might not be enough to fully prevent arrhythmias, but it can help lower the risk.

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“… 6 The P dispersion (Pd) has been shown to be an independent risk factor for atrial fibrillation and atrial flutter. 7 , 8 Tpeak-Tend (Tp-e) interval, Tp-e dispersion, Tp-e/QT and Tp-e/QTc measured in the surface ECG have recently played a part in the articles of the literature, and these are new parameters used to evaluate ventricular arrhythmogenity in many diseases. In studies in which the aforementioned parameters compared with those such as QTd, QTc, and QTcd, which were used for a relatively long time, they were shown to give as reliable results as at least these measurements for detecting impaired ventricular repolarization.…”

Section: Introductionmentioning

confidence: 99%

The effect of type 2 diabetes on electrocardiographic markers of significant cardiac events

Kuzu¹

2018

Pak J Med Sci

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Background & Objectives:In diabetics, cardiac microvascular circulation disorder increases the risk of arrhythmia and sudden cardiac death. Tpeak-Tend (Tp-e) interval, Tp-e dispersion, and Tp-e/QT and Tp-e/QTc ratios measured by surface electrocardiogram (ECG) are new parameters used to evaluate ventricular arrhythmogenity. We aimed to compare QT dispersion (QTd), corrected QT dispersion (QTcd), P dispersion (Pd), Tp-e interval, Tp-e dispersion, and Tp-e/QT and Tp-e/QTc ratios in patients with type- 2 diabetes (T2D) with healthy population.Methods:Electrocardiographic parameters of a total of 100 patients diagnosed with T2D were retrospectively analyzed and compared with the ECG results of 100 healthy age-, sex-, and body weight and height-matched controls.Results:The Pd, QT interval, QTc interval, QTd, QTcd, Tp-e/QT, Tp-e/QT ratios were higher in the patients. A statistically significant correlation was found only between hemoglobin A1c and Tp-e dispersion, QTd, QTcd, Pd, Tp-e/QT and Tp-e/QTc parameters, in linear regression analysis. There was also a statistically significant positive correlation between the values of low-density lipoprotein, systolic blood pressure, and Tp-e dispersion.Conclusion:The risk of arrhythmia can be predicted by evaluating Tp-e interval, Tp-e dispersion, Tp-e/QT, and Tp-e/QTc ratio, suggesting heterogeneity of ventricular repolarization and P wave and Pd showing heterogeneity of atrial repolarization in diabetic patients.

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The Impact of 3:1 Ketogenic Diet on Cardiac Repolarization Changes in Children with Refractory Seizures: A Prospective Follow-Up Study

Cited by 10 publications

References 21 publications

Efficacy and Safety of a Ketogenic Diet in Children and Adolescents with Refractory Epilepsy—A Review

Efficacy and Safety of a Ketogenic Diet in Children and Adolescents with Refractory Epilepsy—A Review

Impact of Dietary Factors on Brugada Syndrome and Long QT Syndrome

The effect of type 2 diabetes on electrocardiographic markers of significant cardiac events

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