The IMPACT OF 17β-Estradiol ON THE HEME OXYGENASE ACTIVITY AND TBA-ACTIVE PRODUCTS LEVEL IN VESSELS OF OVARIECTOMIZED RATS WITH INSULIN RESISTANCE

Abstract

The effect of 17β-estradiol on the heme oxygenase activity and TBA-active products level in vessels of variectomized rats with insulin resistance was investigated. Insulin resistance induced by high fructose diet in ovariectomized rats led to increase in heme oxygenase activity and TBA-active products level in vessels. Administration of 17β-estradiol prevented increase in heme oxygenase activity and TBA-active products level, that could be explained by amelioration of insulin resistance and normalization of prooxidant-antioxidant state and could be considered the one of possible mechanisms of vasoprotective estradiol effect.