The immunosuppressive effect of acute doses of emetine on murine thymic cells

Antoni, Ferenc András; Luat, Nguyem Nghiem; Csuka, I; Oláh, Ilona; Sooki-Toth, A.; Bánflavi, G.

doi:10.1016/0192-0561(87)90058-0

Cited by 12 publications

(3 citation statements)

References 17 publications

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“…Experimentation with the protein synthesis inhibitor emetine dihydrochloride was used to eliminate plasma cells from the HG since it was previously found to have dramatic effects on DNA, RNA, and protein synthesis (Antoni et al, 1987;Farkas et al, 1974). Our light microscopy experiment showed that plasma cells are nearly all eliminated following emetine dihydrochloride treatment, but these cells repopulate the gland and return to numbers equivalent to those found in control chickens by 1 week.…”

Section: Resultsmentioning

confidence: 99%

Immune cell proliferation in the Harderian gland: An avian model

Scott

Savage

1996

Microsc. Res. Tech.

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Section: Resultsmentioning

confidence: 99%

Immune cell proliferation in the Harderian gland: An avian model

Scott

Savage

1996

Microsc. Res. Tech.

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“…94 Emetine has also been reported to inhibit DNA synthesis in sea urchin 95 and mice. 96 Emetine specifically targets and blocks the early S phase of DNA replication. 97 The potential of this naturally occuring drug to inhibit protein synthesis was used in maintenance of the activity of alcohol dehydrogenase to reduce the pathological alcohol addiction.…”

Section: Biological Activities Of Emetine and Cephalinementioning

confidence: 99%

A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review

Mondal¹,

Moktan²

2020

IJPER

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Background: Carapichea ipecacuanha (Brot.) L. Andersson is the botanical source of Ipecac drug and contains major alkaloids emetine, cephaline that are pharmaceutically used against bronchitis associated with cough in children, severe diarrhea (amoebic dysentery) and also cancer. Ipecac serves as an expectorant to thin mucous and easy coughing. Low doses are used to enhance appetite and it is administered orally to cause vomiting after suspected poisoning. Materials and Methods: The review highlights the taxonomy, nomenclature, distribution, medicinal uses and major pharmacological activities including side effects of Ipecac drug reported in recent years consulting various published papers dealing with Ipecac. Results and Conclusion: The species is rarely distributed due to disturbances in their habitats in natural growing condition. Further studies are required to scientifically evaluate the traditional uses of this plant through extraction and identification of their active ingredients and the mechanisms and mode of action that would serve as a source of collective information on this plant.

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“…Emetine acts by blocking the early S phase of DNA replication [21]. At a single dose of 33 mg/Kg, administered subcutaneously to mice, DNA, RNA and protein synthesis of thymic cells were reduced by 90, 50 and 65%, respectively [22].…”

Section: Inhibition Of Protein Dna and Rna Syn-thesismentioning

confidence: 99%

Biological Activities of Emetine

Akinboye¹,

Bakare

2011

TONPJ

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Emetine is a natural product alkaloid from ipecac species. It is one of the main active ingredients in ipecac syrup used as emetic, and has been used extensively in phytomedicine as an antiparasitic drug. It inhibits both ribosomal and mitochondrial protein synthesis and interferes with the synthesis and activities of DNA and RNA. For this reason, it has been a vital tool to pharmacologists and has demonstrated many biological properties, such as antiviral, anticancer, antiparasitic and contraceptive activities. Also, it has been reported to cause the up-regulation and down-regulation of a number of genes. Some synthetic analogs with interesting biological activities have been prepared. This article reviews the biological activities of emetine and some emetine derived molecules.

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The immunosuppressive effect of acute doses of emetine on murine thymic cells

Cited by 12 publications

References 17 publications

Immune cell proliferation in the Harderian gland: An avian model

Immune cell proliferation in the Harderian gland: An avian model

A Paradoxically Significant Medicinal Plant Carapichea ipecacuanha: A Review

Biological Activities of Emetine

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