The immunostimulant OM-85 BV prevents wheezing attacks in preschool children

Razi, Cem Hasan; Harmancı, Koray; Abacı, Ayhan; Özdemir, Osman; Hızlı, Şamil; Renda, Rahime; Keskin, Fersin

doi:10.1016/j.jaci.2010.07.038

Cited by 160 publications

(162 citation statements)

References 38 publications

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“…[31][32][33] For example, a randomized controlled trial of 94 preterm infants reported that supplementation of prebiotics and probiotics (Lactobacillus rhamnosus) led to a lower incidence of rhinovirus ARIs. 31 Another clinical trial of 326 healthy children also reported that…”

Section: Microbiota Profi Les and Bronchiolitismentioning

confidence: 99%

The Fecal Microbiota Profile and Bronchiolitis in Infants

et al. 2016

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Section: Microbiota Profi Les and Bronchiolitismentioning

confidence: 99%

The Fecal Microbiota Profile and Bronchiolitis in Infants

et al. 2016

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“…Their mechanism of action appears to be loosely analogous to that described for B. fragilis PSA: these products interact with dendritic cells in the gut mucosa, which in turn induced an increase in the frequency and number of FoxP31 T-regulatory cells in the intestinal lamina propria, the airway mucosa, and to a smaller extent in the vagina, but not in secondary lymphoid organs (30). Whether these same products can prevent the development of asthma in young children is still unknown (32,33). A different approach could be administration of live microorganisms, as has been attempted with probiotic and synbiotic preparations containing a small number of allegedly beneficial bacteria.…”

Section: Parker B Francis Lecturementioning

confidence: 85%

The Human Microbiome. Early Life Determinant of Health Outcomes

Martínez

2014

Annals ATS

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The development of new technologies to isolate and identify microbial genomes has markedly increased our understanding of the role of microbiomes in health and disease. The idea, first proposed as part of the hygiene hypothesis, that environmental microbes influence the developmental trajectories of the immune system in early life, has now been considerably extended and refined. The abundant microbiota present in mucosal surfaces, especially the gut, is actively selected by the host through complex receptor systems that respond differentially depending on the molecular patterns presented to mucosal cells. Germ-free mice are more likely to develop allergic airway inflammation and show alterations in normal motor control and anxiety. These effects can be reversed by neonatal microbial recolonization but remain unchanged if recolonization occurs in adults. What emerges from these recent studies is the discovery of a complex, major early environmental determinant of lifetime human phenotypes. To change the natural course of asthma, obesity, and other chronic inflammatory conditions, active manipulation of the extensive bacterial, phage, and fungal metagenomes present in mucosal surfaces may be required, specifically during the developing years. Domesticating the human microbiome and adapting it to our health needs may be a challenge akin to, but far more complex than, the one faced by humanity when a few dozen species of plants and animals were domesticated during the transition between huntergatherer and sedentary societies after the end of the Pleistocene era.

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“…In addition to the anatomical and physiological features of the respiratory tract the main causes of recurrent respiratory diseases in younger children are age-related transient changes in the immune system. As a number of studies show, not the frequency of recurrent respiratory tract infections itself, but its nature, the combination of viral and bacterial infections and severe prolonged bacterial infections allow assuming the presence of immune pathology [2][3][4]. At the same time, an increased infectious morbidity is a characteristic not only in children with classical immune pathology, but also in so-called immunocompromised children with various allergic reactions [5].…”

Section: Introductionmentioning

confidence: 99%

Characteristic of cellular immunity in children with recurrent respiratory diseases, depending on the level of immunoglobulin E production

Shumna

Nedelska

Solovieva

et al. 2017

ZMJ

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Purpose. To analyze the indices of cellular immunity in children with recurrent respiratory diseases, depending on the level of IgE production. Materials and methods.The study of cellular immunity and the level of IgE production in 81 children with recurrent respiratory diseases, aged from 2 to 6 years old (I group -45 children with IgE index above the reference values of the age norm; II group -36 children with normal IgE level).Results. In 55.56 % of children with recurrent respiratory diseases, the IgE level has exceeded the reference values of the age norm. Cellular immunity in 53.33 % of children with recurrent respiratory diseases and high IgE levels was significantly more often characterized by decrease in the relative amount of CD3+, CD4+ T-lymphocytes phenotype and increase in the relative values of CD25+ lymphocytes phenotype with a moderate positive direct correlation between CD25+ lymphocytes and IgE levels (R = 0.35, P < 0.05). In children with recurrent respiratory diseases and normal IgE levels the relative amount of СD3+, CD4+, CD8+ lymphocytes phenotype was decreased and increased CD16+, CD19+ phenotypes in 38.89 %, and increase in the relative values of CD25+ lymphocytes phenotype in 11.1 %. Regardless of the ability to IgE production the cellular immunity parameters within the age standard were recorded in 53.09 % of the examined children and violation of the cellular immunity was observed in 46.91 % of cases. Conclusions.In children with recurrent respiratory diseases changes in the cellular immunity were registered 14.44 % more often in the group of children with high IgE level.Характеристика показників клітинного імунітету в дітей із рекурентними респіраторними захворюваннями залежно від здатності до утворення імуноглобуліну EМета роботи -аналіз і визначення взаємозв'язку показників клітинного імунітету в дітей із рекурентними респіраторними захворюваннями залежно від рівня імуноглобуліну Е.Матеріали та методи. Обстежили 81 дитину з рекурентними респіраторними захворюваннями віком 2-6 років (І група спостереження -45 дітей, з показниками імуноглобуліну E, вищими за референтні значення вікової норми; ІІ група -36 дітей із нормальним рівнем імуноглобуліну E.Результати. У 55,56 % дітей із рекурентними респіраторними захворюваннями рівень імуноглобуліну E перевищував референтні значення вікової норми. Клітинний імунітет у 53,33 % дітей із рекурентними респіраторними захворюваннями та високим рівнем імуноглобуліну E характеризувався зниженням відносної кількості Т-лімфоцитів із фенотипом СD3+ і CD4+ і підвищенням лімфоцитів із фенотипом CD25+, із помірним позитивним прямим кореляційним зв'язком між показниками CD25+ та імуноглобуліном E (R = 0,35, р < 0,05). У дітей із рекурентними респіраторними захворюваннями та нормальним рівнем імуноглобуліну E в 38,89 % випадків реєструвалось зниження відносної кількості Т-лімфоцитів із фенотипами СD3+, CD4+, CD8+ та підвищення CD16+ і CD19+, а тільки в 11,1 % -підвищення лімфоцитів із фенотипом CD25+. Незалежно від здатності до утворення імуноглобуліну E, ...

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The immunostimulant OM-85 BV prevents wheezing attacks in preschool children

Cited by 160 publications

References 38 publications

The Fecal Microbiota Profile and Bronchiolitis in Infants

The Fecal Microbiota Profile and Bronchiolitis in Infants

The Human Microbiome. Early Life Determinant of Health Outcomes

Characteristic of cellular immunity in children with recurrent respiratory diseases, depending on the level of immunoglobulin E production

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