The Immunophenotype of Bone Marrow Lymphocytes in Children with Immune Thrombocytopenic Purpura

Alavi, Samin; Aryan, Zahra; Ghazizadeh, Farid; Arabi, Nahid; Nikougoftar, Mahin; Ebadi, Maryam

doi:10.3109/08880018.2014.927944

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Similar to our study, other studies showed that CD10, CD19, and CD20 B-cell markers were significantly higher in children with acute and or chronic ITP in bone marrow aspiration (12,13). CD19 has been bone marrow in the group of ITP patients because it needed to diagnose them.…”

Section: Discussionsupporting

confidence: 91%

Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura

et al. 2020

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Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction. An impaired immune system may induce by or be associated with ITP. Objectives: This study aimed to evaluate complement and humoral immune systems in ITP. Methods: We evaluated 30 children (under 19 years old) with acute and chronic ITP referred to a tertiary hospital and compared them with 30 healthy volunteers. We assessed the samples' CBC with differentiation, serum immunoglobulins (IgG, IgE, IgM, IgA, IgG1, IgG2, IgG3, IgG4) by nephelometry, antistreptolysin O titer by agglutination, CH50, C3, C4 by nephelometry, CD19 by flow cytometry, and anti-tetanus antibody titer by ELISA. Their demographic data were obtained with a questionnaire. Results: Our findings showed that humoral and complement components were normal in both patients and healthy groups. However, based on independent t test results, the mean serum levels of IgM, IgE, IgG1, C3, and tetanus antibody levels were significantly higher in the patient group. Conclusions: Humoral and complementary immunodeficiency in these patients is unlikely. However, more studies with larger sample sizes are needed.

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Section: Discussionsupporting

confidence: 91%

Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura

et al. 2020

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“…Moreover, infections caused by the invasion of pathogenic microorganisms are also important causes (16)(17)(18). In terms of the specific signaling pathways, the B cell receptor (BCR) pathway of peripheral blood B-lymphocytes in IRH patients is enhanced, and the number and function of CD22 are also enhanced (19,20). The expression of the transcription factor, Transcription factor 2 (Bach2), is also different between IRH patients and normal controls, suggesting that Bach2 is also related to the occurrence of IRH (21).…”

Section: Discussionmentioning

confidence: 99%

Atorvastatin improves bone marrow endothelial progenitor cell function from patients with immune-related hemocytopenia

Qian¹,

Shen

Yan³

et al. 2021

Ann Transl Med

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Background: Immune-related hemocytopenia (IRH) is a type of autoimmune disease that targets bone marrow hematopoietic cells. This study investigated the influence of atorvastatin on the functional aspects of bone marrow endothelial progenitor cells (BM EPCs) in IRH patients. Methods: BM EPCs were isolated from 15 patients with IRH and 20 normal controls. The isolated BM EPCs were characterized by flow cytometry. Cell counting kit-8, flow cytometry, and Transwell migration assays were used to determine the proliferation, apoptosis, and migration of BM EPCs, respectively. Protein levels were determined by western blot assay. Results: The BM EPCs isolated from IRH patients showed reduced proliferation, increased apoptosis, and attenuated migratory ability compared to those from normal controls. Western blot analysis showed that the protein level of p-p38 was significantly increased, while that of Phosphorylated protein kinase B (p-AKT) was significantly decreased in the BM EPCs from IRH patients, compared to BM EPCs from healthy subjects. Cell proliferation and migration were significantly enhanced by atorvastatin, recombinant human thrombopoietin, and SB20358 compared to the untreated BM EPCs from IRH patients. Atorvastatin, Recombinant human thrombopoietin (TPO), and SB20358 treatment significantly suppressed the protein levels of p-p38 protein, but increased those of p-AKT in BM EPCS from IRH patients. Conclusions: In summary, atorvastatin increases the number and function of BM EPCs in IRH patients by regulating the p38 and AKT signaling pathways.

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Clinical utility of the CD10+/HLA-DR+ population in bone marrow mononuclear cells from adults with immune thrombocytopenia

Tabata¹,

Tabata

2022

International Immunopharmacology

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The Immunophenotype of Bone Marrow Lymphocytes in Children with Immune Thrombocytopenic Purpura

Cited by 4 publications

References 18 publications

Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura

Humoral and Complement Systems in Children With Acute Immune Thrombocytopenic Purpura

Atorvastatin improves bone marrow endothelial progenitor cell function from patients with immune-related hemocytopenia

Clinical utility of the CD10+/HLA-DR+ population in bone marrow mononuclear cells from adults with immune thrombocytopenia

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