The Immunopathology of Pulmonary Rejection after Murine Lung Transplantation
Janne Kaes,
Emilie Pollenus,
Charlotte Hooft
et al.
Abstract:To improve outcomes following lung transplantation, it is essential to understand the immunological mechanisms that result in chronic graft failure. The associated clinical syndrome is termed chronic lung allograft dysfunction (CLAD), which is known to be induced by alloimmune-dependent (i.e., rejection) and alloimmune-independent factors (e.g., infections, reflux and environmental factors). We aimed to explore the alloimmune-related mechanism, i.e., pulmonary rejection. In this study, we use a murine orthotop… Show more
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