The immunomodulatory effects of measles‐mumps‐rubella vaccination on persistence of heterologous vaccine responses

Zimmermann, Petra; Perrett, Kirsten P.; Klis, Fiona R.M. van der; Curtis, Nigel

doi:10.1111/imcb.12246

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…For example, the Bacille Calmette-Guérin (BCG) vaccine for Mycobacterium tuberculosis, used in countries where tuberculosis is still prevalent, modulates the innate immune response and induces protection against non-mycobacterial species and some types of cancers [16][17][18][19] . Similar effects have been observed with the measles, mumps, and rubella (MMR) vaccine 20,21 .…”

Section: Introductionsupporting

confidence: 60%

Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

et al. 2022

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Whole cell vaccines are complex mixtures of antigens, immunogens, and sometimes adjuvants that can trigger potent and protective immune responses. In some instances, such as whole cell Bordetella pertussis vaccination, the immune response to vaccination extends beyond the pathogen the vaccine was intended for and contributes to protection against other clinically significant pathogens. In this study, we describe how B. pertussis whole cell vaccination protects mice against acute pneumonia caused by Pseudomonas aeruginosa. Using ELISA and western blot, we identified that B. pertussis whole cell vaccination induces production of antibodies that bind to lab-adapted and clinical strains of P. aeruginosa, regardless of immunization route or adjuvant used. The cross-reactive antigens were identified using immunoprecipitation, mass spectrometry, and subsequent immunoblotting. We determined that B. pertussis GroEL and OmpA present in the B. pertussis whole cell vaccine led to production of antibodies against P. aeruginosa GroEL and OprF, respectively. Finally, we showed that recombinant B. pertussis OmpA was sufficient to induce protection against P. aeruginosa acute murine pneumonia. This study highlights the potential for use of B. pertussis OmpA as a vaccine antigen for prevention of P. aeruginosa infection, and the potential of broadly protective antigens for vaccine development.

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Section: Introductionsupporting

confidence: 60%

Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

et al. 2022

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“…Interestingly, we found negative correlations between responses to the live-vaccines measles, mumps and rubella, and non-live vaccines (MenC, tetanus, Hib). The finding is not easily explained as several studies have shown that simultaneous or delayed administration of MMR does not influence antibody concentrations to non-live vaccines ( 11 – 14 ).…”

Section: Discussionmentioning

confidence: 87%

Correlation of Vaccine Responses

et al. 2021

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IntroductionThe humoral response to vaccinations varies widely between individuals. There is no data available on the correlation between responses to different vaccines. In this study, we investigated the correlation of antibody responses between routine vaccine antigens in infants.MethodsOne and seven months after the 6-month vaccinations and one month after the 12-month vaccinations, antibody concentrations to diphtheria, tetanus, pertussis, polio (serotypes 1-3), Haemophilus influenzae type b (Hib), pneumococcus (13 serotypes), meningococcus C, measles, mumps and rubella were measured using fluorescent bead-based multiplex immune-assays. For the correlation of antibody responses, Spearman’s rank correlation coefficients (ρ) with 95% confidence intervals (CI) were calculated between responses to each vaccine antigen.ResultsThe correlation between concentrations of antibodies to the vaccinations ending at 6 months of age was higher one month compared to seven months after vaccination. The strongest correlations at both time points were observed between antibody responses to different polio serotypes, certain pneumococcal serotypes and between responses to diphtheria and pneumococcal (conjugated to a diphtheria toxoid) vaccine antigens. Correlation between responses to tetanus, Hib, pertussis, polio and other vaccine antigens were weak. The correlation between antibody responses to the 12-month vaccine antigens was weaker than to the 6-month vaccine antigens and there was a negative correlation between responses to measles, mumps, rubella vaccine and non-live vaccine antigens (meningococcus C, tetanus and Hib). There was only weak correlation between antibody responses to vaccines of the same type (e.g. conjugated polysaccharide or toxoid vaccines).ConclusionCorrelation between antibody responses to similar antigens in the same vaccine (such as different serotypes of a bacteria or virus), as well as responses to antigens conjugated to similar carrier proteins, are strong. In contrast, correlation between responses to other vaccines are weak. Measuring antibody responses to one or a few vaccine antigens therefore does not offer a reliable surrogate marker of responses to unrelated vaccines.

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“…Live attenuated vaccines, including BCG (Bacillus Calmette Guerin) and MMR (measles, mumps and rubella) are known to activate innate immune responses in addition to vaccine-specific immune responses, leading to a bystander or off-target effects on the immune system (10)(11)(12)(13)(14). The role of COVID vaccines in inducing such an effect remains unexplored.…”

Section: Discussionmentioning

confidence: 99%

Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses

Kumar

Banurekha

et al. 2021

Front. Immunol.

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Covaxin/BBV152 is a whole virion inactivated SARS-CoV-2 vaccine. The effect of prime-boost vaccination with Covaxin on systemic immune responses is not known. We investigated the effect of Covaxin on the plasma levels of a wide panel of cytokines and chemokines at baseline (M0) and at months 1 (M1), 2 (M2) and 3 (M3) following prime-boost vaccination in healthy volunteers. Our results demonstrate that Covaxin induces enhanced plasma levels of Type 1 cytokines (IFNγ, IL-2, TNFα), Type 2/regulatory cytokines (IL-4, IL-5, IL-10 and IL-13), Type 17 cytokine (IL-17A), other pro-inflammatory cytokines (IL-6, IL-12, IL-1α, IL-1β) and other cytokines (IL-3 and IL-7) but diminished plasma levels of IL-25, IL-33, GM-CSF and Type 1 IFNs. Covaxin also induced enhanced plasma levels of CC chemokine (CCL4) and CXC chemokines (CXCL1, CXCL2 and CX3CL1) but diminished levels of CXCL10. Covaxin vaccination induces enhanced cytokine and chemokine responses as early as month 1, following prime-boost vaccination, indicating robust activation of innate and adaptive immune responses in vaccine recipients.

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The immunomodulatory effects of measles‐mumps‐rubella vaccination on persistence of heterologous vaccine responses

Cited by 9 publications

References 46 publications

Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

Bordetella pertussis whole cell immunization protects against Pseudomonas aeruginosa infections

Correlation of Vaccine Responses

Prime-Boost Vaccination With Covaxin/BBV152 Induces Heightened Systemic Cytokine and Chemokine Responses

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