The immunomodulatory ballet of tumour‐derived extracellular vesicles and neutrophils orchestrating the dynamic CD73/PD‐L1 pathway in cancer
Dominique S. Rubenich,
Jordana L. Domagalski,
Gabriela F. S. Gentil
et al.
Abstract:Head and neck squamous cell carcinoma (HNSCC) is a global cancer burden with a 5‐year overall survival rate of around 50%, stagnant for decades. A tumour‐induced immunosuppressive microenvironment contributes to HNSCC progression, with the adenosine (ADO) pathway and an upregulated expression of inhibitory immune checkpoint regulators playing a key role in this context. The correlation between high neutrophil‐to‐lymphocyte ratio (NLR) with advanced tumour staging suggests involvement of neutrophils (NØ) in can… Show more
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