The immunomodulating properties of arbidol

Surinov, B. P.; Karpova, N. A.; Kulish, Yu. S.

doi:10.1007/bf02219057

Cited by 3 publications

(6 citation statements)

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“…This effect is similar to the bystander effect demonstrated on cultured cells and manifesting in genome instability in intact cells surrounding the irradiated cell [9]. In our experiments this effect was observed in animals and was determined by urinary excretion of volatile components reducing humoral immune reactivity in intact animals even after a shortterm exposure (1 h or 1 day) [6][7][8].…”

supporting

confidence: 77%

“…Volatile compounds released on day 3 after irradiation possess a high immunosuppressive activity [6]. Immune reactivity of highly reactive recipient CBA mice decreased equally after exposure to postirradiation secretion of syngeneic CBA mice (62.0±5.6%) and allogeneic C57Bl/6 mice (69.2±1.6%) ( Table 1).…”

Section: Resultsmentioning

confidence: 97%

“…There are no publications about chemical signals of pathological states and their effects on intact animals. The only exception is reports about "fear smell" release by stressed animals; this smell modified the immunity of intact animals [6,13].…”

mentioning

confidence: 94%

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Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

2004

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The immune response in immunologically and olfactorily high- and low-reactive CBA and C57Bl/6 mice is almost similarly decreased after exposure to volatile secretions of syngeneic animals exposed to ionizing radiation in a dose of 4 Gy. In the preference/avoidance test intact animals prefer secretions of irradiated syngeneic and allogeneic animals to those of intact animals, while without irradiation animals of both strains prefer syngeneic secretions. C57Bl/6 mice differ from CBA animals by lower sensitivity.

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supporting

confidence: 77%

Section: Resultsmentioning

confidence: 97%

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Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

2004

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“…Therefore, the stimulating activity of arbidol with respect to the antibody production is not related to inhibition of the antigen-dependent suppressors. The activity is apparently due to participation of the cells of some other types, in particular, phagocytizing cells whose function can be also stimulated by arbidol [8]. In the mice with tumor, a significant stimulation of the antibody production was observed only after the fivefold drug administration ( nents of the immune system, whose functions are significantly modified in the ani-" Data reliable forp < 0.05 (against the drug-tree control).…”

Section: Resultsmentioning

confidence: 90%

“…In order to elucidate the mechanism of the immunomodulating action of arbidol, we have studied the effect of the drug on the antigen-induced suppressor activity. Previously [8] we reported that arbidol did not affect the induction of antigen dependent splenic suppressors in intact mice. In this work, we have established that introduction of the drug into irradiated mice also has no significant effect on this function.…”

Section: Resultsmentioning

confidence: 98%

Comparative study of the immunomodulating properties of arbidol and levamisole under ionizing radiation and malignant conditions

Surinov

Karpova

1997

Pharm Chem J

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The great diversity of immunodeficient states and factors affecting the immune reactivity lead to the necessity of developing and testing immunomodulating preparations capable of introducing appropriate corrections [1 -3]. Use of the immunomodulating drugs in the combined therapy of oncologic diseases is a problem of current importance because all specific antitumor drugs and ionizing radiations exhibit more or less pronounced immunodepressant effect [4,5]. The action of these factors usually develops on the background of immune deficiency caused by the presence of a malignant tumor.Unfortunately, the number of immunomodulating drugs available in practice is small [3].Arbidol, or 6-bromo-5-hydroxy-4-dimethylaminomethyl-1-methyl-2-phenylthiomethyl-3-ethoxyearhydrochloride monohydrate, is a new domestic antiviral drug possessing immunomodulating properties. The drug offers good prospects in the prophylaxis and therapy of both viral diseases and disorders induced by ionizing radiation [6 -8].Levamisole, or (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2, l-b]thiazole hydrochloride (also known as decaris), is an antihelminthic drug reported also to possess pronounced immunomodulating properties [9]. There is evidence that the drug can be used in oncology and medical radiology for the purpose of immune reactivity correction [10][11][12].It was therefore an important task to compare the immunomodulating activity of arbidol and levamisole under the conditions of ionizing radiation and experimental malignancy in animals.

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Pharmacokinetic properties and bioequivalence of two formulations of arbidol: An open-label, single-dose, randomized-sequence, two-period crossover study in healthy chinese male volunteers

Liu¹,

Wang²,

Yao³

et al. 2009

Clinical Therapeutics

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The immunomodulating properties of arbidol

Cited by 3 publications

References 1 publication

Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

Postirradiation volatile secretions of mice: syngeneic and allogeneic immune and behavioral effects

Comparative study of the immunomodulating properties of arbidol and levamisole under ionizing radiation and malignant conditions

Pharmacokinetic properties and bioequivalence of two formulations of arbidol: An open-label, single-dose, randomized-sequence, two-period crossover study in healthy chinese male volunteers

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