The Immunology of Schistosomiasis

Smithers, S. R.; Terry, R. J.

doi:10.1016/s0065-308x(08)60518-7

Cited by 120 publications

(62 citation statements)

References 58 publications

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“…Ces observations sont tout à fait en accord avec les notions généralement admises concer nant l 'immunité au cours de la schistosomiase : l 'organisme infesté par le parasite développe une résistance à la réinfestation qui s'exerce aux dépens des formes lar vaires d'invasion du parasite ; mais cet état de résistance est incapable d'entraîner l'élimination de la population de vers adultes déjà installés dans l'organisme (état d'immunité concomitante). Des antigènes de l'hôte se fixent sur les schistosomules au cours de leur migration et masqueraient ainsi les antigènes parasitaires, permet tant ensuite aux parasites plus âgés d'échapper aux réactions immunologiques de l'organisme (11). Un tel processus ne peut, semble-t-il, intervenir dans le déroulement d'une immunostimulation non spécifique telle que celle obtenue par le B.C.G.…”

Section: Discussionunclassified

Influence du bacille de Calmette et Guérin (B.C.G.) sur la migration larvaire de Schistosoma mansoni chez la Souris

Tribouley

Tribouley-Duret

Appriou

1980

Ann. Parasitol. Hum. Comp.

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Résumé.L'injection de B.C.G. à la Souris entraîne une augmentation de la résistance non spécifi que de l'organisme vis-à-vis de Schistosoma mansoni, se traduisant par une importante dimi nution du nombre des schistosomules pulmonaires ; les mécanismes de défense mis en jeu semblent intervenir de façon précoce dès les premiers stades de migration larvaire du para site. L'état de résistance non spécifique ainsi obtenu apparaît de façon progressive après l'ino culation du bacille ; il se maintient plusieurs semaines bien qu'il ait alors tendance à s'atté nuer. Une réinoculation de B.C.G. à l'animal déjà sensibilisé aux antigènes du bacille entraîne une immunostimulation beaucoup plus intense et dont le délai d'apparition est beaucoup plus court. S u m m a ry . Effects o f Bacillus Calmette and Guérin (B.C.G.) on larvae migration o f Schistosom a mansoni in mice.The injection of B.C.G. into mice results in an increase of non-specific resistance in the organism against Schistosoma mansoni characterized by a sharp reduction in the number of pulmonary schistosomules ; the defense mechanisms involved appear to act early in first stages of migration by the parasite larvae. The state of non-specific resistance thus obtained appears progressively following innoculation of the bacillus ; it is maintained for several weeks despite its tendency to weaken afterwards. Re-inoculation of B.C.G. in an animal which has already been sensitized to the antigens of the bacillus results in a immunostimulation which is far more intense and which appears much earlier on.Accepté le 14 novembre 1979.

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Section: Discussionunclassified

Influence du bacille de Calmette et Guérin (B.C.G.) sur la migration larvaire de Schistosoma mansoni chez la Souris

Tribouley

Tribouley-Duret

Appriou

1980

Ann. Parasitol. Hum. Comp.

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“…Though some evidence has been provided for protective immunity in schistosomiasis, the adult worm escapes the immune response of the host. Among these escape mechanisms, acquisition of host antigens and antigenic competition have now been well documented [2]. In the present paper, we describe the inhibition of lymphocyte proliferation (measured by DNA synthesis) by factor(s) present in the S. mansoni incubation product and released by the worm in cell-free supernatant of in vitro culture and also in serum from infected animals.…”

Section: Introductionmentioning

confidence: 98%

Inhibition of lymphocyte proliferation by factor(s) produced by Schistosoma mansoni

et al. 1977

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Normal spleen cells of CBA mice or Fischer rats were cultured with mitogens or allogeneic cells, together with various substances of Schistosoma mansoni origin, and thymidine uptake was measured. The proliferation (DNA synthesis) of normal lymphocytes was inhibited by the incubation product of the parasite as well as by cell-free supernatant of schistosome culture. Inhibition was obtained only when active materials were added at the beginning of the culture. Both T and B cell proliferation were inhibited. The inhibitory activity found in cell-free supernatant suggested the release by the parasite of some factor(s) interfering with lymphocyte proliferation. Moreover, serum from rats infected by S. mansoni inhibited lymphocyte proliferation also. The inhibitor(s) appeared heat resistant, dialyzable and of low molecular weight (500-1000). Incubation of normal spleen cells with S. mansoni inhibitor(s) did not enhance the release of nonspecific suppressor cell factor. The inhibition of product(s) released by the parasite could explain part of the immunosuppression status found in schistosomiasis.

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“…In humans (1) and experimental animals (2,3), natural infection with the parasitic trematode Schistosoma mansoni induces a partial resistance to reinfection, and antibodies reactive against the surface of invading larvae may play an essential role in the development of this immunity (4). The majority of these antibodies recognize carbohydrate epitopes associated with surface glycoproteins of Mr 17,000, 38,000, 160,000, and >200,000 (5).…”

Section: Introductionmentioning

confidence: 99%

A Schistosoma mansoni epitope recognized by a protective monoclonal antibody is identical to the stage-specific embryonic antigen 1.

Dräger

Harn

1990

Proc. Natl. Acad. Sci. U.S.A.

114

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The Immunology of Schistosomiasis

Abstract: A French translation of the Memorandum will be published in a future issue of the Bulletin.

Cited by 120 publications

References 58 publications

Influence du bacille de Calmette et Guérin (B.C.G.) sur la migration larvaire de Schistosoma mansoni chez la Souris

Influence du bacille de Calmette et Guérin (B.C.G.) sur la migration larvaire de Schistosoma mansoni chez la Souris

Inhibition of lymphocyte proliferation by factor(s) produced by Schistosoma mansoni

A Schistosoma mansoni epitope recognized by a protective monoclonal antibody is identical to the stage-specific embryonic antigen 1.

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