The immunology of exceptional individuals: the lesson of centenarians

Franceschi, Claudio; Monti, Daniela; Sansoni, Paolo; Cossarizza, Andrea

doi:10.1016/0167-5699(95)80064-6

Cited by 505 publications

(269 citation statements)

References 27 publications

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“…5 A dysregulation of both immune and inflammatory responses occurring with increasing age is believed to substantially contribute to morbidity and mortality in humans. [6][7][8] Conversely, human longevity seems to be directly correlated with optimal functioning of the immune system, 9 suggesting that some genetic determinants of successful ageing might reside in those polymorphisms for the immune system genes that regulate immune responses. 5,10 In several cytokine genes, polymorphisms located within promoter regions, mostly single nucleotide polymorphisms (SNP), or microsatellites, have been described which affect gene transcription, causing interindividual variations in cytokine production.…”

Section: Introductionmentioning

confidence: 99%

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

et al. 2002

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Section: Introductionmentioning

confidence: 99%

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

et al. 2002

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“…Longevity is associated with appropriate immune function (Sansoni et al, , 1997Franceschi et al, 1995). Moreover, recent research indicates that the immune system is not autonomous.…”

Section: Introductionmentioning

confidence: 99%

Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets

Schindowski

Fröhlich

Maurer

et al. 2002

Mechanisms of Ageing and Development

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The relevance of physiological immune aging is of great interest with respect to determining disorders with pathologic immune function in aging individuals. In recent years, the relevance of changes in peripheral lymphocytes in age-associated neurologic diseases has become more evident. Due to the lack of immunological studies. covering moce than one event after mitogenic activation, we envisaged a new concept in the present study, aiming to investigate several events, starting from T cell receptor (TCR) ligation up to T cell proliferation. In addition, we addressed the question whether changes are present in the subsets (CD4, CDR) with aging. Phosphorylation of tyrosine residues declines with increasing age in CD4+ cells. Fewer levels of CD69 positive cells after 4 h mitogenic activation, altered expression of cytokines (IL2, IFN-7 and TNF-a; 22 h) and lower proliferation (72 h) were detemined in aging. Moreover, it could be shown that CD8" lymphocytes react more effectively to mitogenic stirnulation with referenoe to CD69 expression and proliferation in both age groups ( < 35 and > 60 years old). These data indicate that T cell activation, rnediated by TCR engagement, is significantly impaired in aging and both subsets are affected. However, bypassing the TCR does not fully restore T cell function, indicating that there are more mechanisms involved than impaired signal transduction thwugh TCR only. The results will be discussed in relation to iiheir relevance in neurodegenerative and psychiatric disorders.

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“…These findings in various strains of rodents stand in some contrast to the less consistent declines in immune function observed in humans (30,31,32,33). These findings are therefore difficult to apply directly to humans, however, the diet-induced alterations in such physical properties as membrane fluidity or fatty acid composition are intriguing and merit further study.…”

Section: Amelioration Of Immune Function In Long-lived Strains Of Animentioning

confidence: 78%

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

Troyer

Venkatraman

Fernandes

1998

AGE

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Aging is accompanied by a steady increase in the incidence of spontaneous tumors and a decline in immune function. Calorie restriction (CR) or supplementation with (0-3 fats prolongs life span, suppresses tumorigenesis, and ameliorates immune function in a variety of experimental models. We suggest that decreased oxidant stress and upregulation of apoptosis mediate the effects of calorie restriction on immunity and longevity. CR prolongs life span in several animal models and our studies have examined the effects of CR on the immune system and on tumorigenesis.

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The immunology of exceptional individuals: the lesson of centenarians

Cited by 505 publications

References 27 publications

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

Gender-specific association between −1082 IL-10 promoter polymorphism and longevity

Age-related impairment of human T lymphocytes’ activation: specific differences between CD4+ and CD8+ subsets

Effects of calorie restriction and ω-3 dietary fat on aging in short-and long-lived rodents

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