The Immunohistochemistry of Kaposi’s Sarcoma

Pantanowitz, Liron; Caponetti, Gabriel C.; Dezube, Bruce J.

doi:10.1007/978-90-481-2918-8_33

Cited by 9 publications

(15 citation statements)

References 65 publications

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“…26 IMMUNOHISTOCHEMISTRY More than 100 different primary antibodies have been evaluated in KS with immunohistochemistry. 27 Kaposi sarcoma lesional cells stain positively with the endothelial markers factor VIII-related antigen, CD31 (PECAM-1), and CD34. CD34 tends to show stronger expression than CD31 in advanced-stage lesions of KS.…”

Section: Histologic Variantsmentioning

confidence: 99%

Kaposi Sarcoma

Radu

Pantanowitz

2013

Archives of Pathology &Amp; Laboratory Medicine

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248

207

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Kaposi sarcoma (KS) is a low-grade vascular tumor associated with Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) infection. Kaposi sarcoma lesions predominantly present at mucocutaneous sites, but may involve all organs and anatomic locations. Recognized epidemiologic-clinical forms of KS include classic, African (endemic), AIDS-associated (epidemic), and iatrogenic KS. New clinical manifestations have been described, such as antiretroviral therapy–related KS regression or flares. Kaposi sarcoma lesions evolve from early (patch stage) macules into plaques (plaque stage) that grow into larger nodules (tumor stage). Newer histologic variants include anaplastic, hyperkeratotic, lymphangioma-like, bullous, telangiectatic, ecchymotic, keloidal, pyogenic granuloma–like, micronodular, intravascular, glomeruloid and pigmented KS, as well as KS with sarcoidlike granulomas and KS with myoid nodules. Latency-associated nuclear antigen (HHV8) is the most specific immunohistochemical marker available to help distinguish KS from its mimics. Since KS remains one of the most common AIDS-defining malignancies, it is important that pathologists be able to recognize KS and its contemporary manifestations.

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Section: Histologic Variantsmentioning

confidence: 99%

Kaposi Sarcoma

Radu

Pantanowitz

2013

Archives of Pathology &Amp; Laboratory Medicine

Self Cite

248

207

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“…During the latent phase, viral DNA copies are maintained as episomes attached to the host chromosome with the help of LNA-1. 50 This explains why LNA-1 immunoreactivity in KS cells most often appears as stippled nuclear staining. Most cells in KS lesions and HHV-8-infected cell cultures are latently infected.…”

Section: Human Herpesvirusmentioning

confidence: 96%

“…These histopathologic variants of KS are characterized by the proliferation of well-formed capillaries organized in lobules and surrounded by epidermal collarets, with no solid aggregates of fusiform cells, and they mimic benign vascular proliferations with a lobular capillary hemangioma pattern. 50 (3) KS presenting in unusual locations. (4) Histopathologic differential diagnosis with other vascular proliferations mimicking KS, such as hobnail hemangioma, spindle cell hemangioma, benign lymphangioendothelioma, and kaposiform hemangioendothelioma.…”

Section: Human Herpesvirusmentioning

confidence: 99%

Immunohistochemistry in the Diagnosis of Cutaneous Viral Infections—Part I. Cutaneous Viral Infections by Herpesviruses and Papillomaviruses

Molina-Ruiz¹,

Santonja²,

Rütten

et al. 2015

The American Journal of Dermatopathology

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“…Histologic features include spindle shaped cells, inflammatory infiltrates, and angioproliferation with erythrocyte extravasation. Endothelial cell markers (CD31, CD34, factor VIII) and lymphatic endothelial cell markers (lymphatic vessel endothelial receptor 1) are oftentimes useful to support the diagnosis of KS . However, detection of HHV‐8 latency‐associated nuclear antigen, expressed in all clinical stages of KS, in spindle cells, which are the proliferating HHV‐8‐infected endothelial cells, is a more definitive histologic diagnosis .…”

Section: Introductionmentioning

confidence: 99%

Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV‐8

Jackson

Dickson

Sadjadi

et al. 2015

Pediatr Blood Cancer

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Kaposi sarcoma (KS) is an endothelial malignancy caused by human herpes virus‐8 (HHV‐8) infection. The epidemic and iatrogenic forms of childhood KS result from a profound and acquired T cell deficiency. Recent studies have shown that classic KS of childhood can result from rare single‐gene inborn errors of immunity, with mutations in WAS, IFNGR1, STIM1, and TNFRSF4. The pathogenesis of the endemic form of childhood KS has remained elusive. We review childhood KS pathogenesis and its relationship to inherited and acquired immunodeficiency to oncogenic HHV‐8.

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The Immunohistochemistry of Kaposi’s Sarcoma

Cited by 9 publications

References 65 publications

Kaposi Sarcoma

Kaposi Sarcoma

Immunohistochemistry in the Diagnosis of Cutaneous Viral Infections—Part I. Cutaneous Viral Infections by Herpesviruses and Papillomaviruses

Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV‐8

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