“…Immunohistochemistry studies for S100 (positive in mature and immature dendritic cells), CD1a (expressed mainly in immature dendritic cells), and CD83 (expressed mainly in mature dendritic cells) found that dendritic cell density was significantly higher in PTC than in normal thyroid tissue, thyroid goiter, follicular carcinoma, follicular adenoma, Hürthle cell carcinoma, Hürthle cell adenoma, medullary thyroid carcinoma, poorly differentiated carcinoma, and undifferentiated carcinoma. [3][4][5][6][7][8][9] Consequently, some authors suggested that the relatively better prognosis of PTC may be due to the immunogenic effect of dendritic cells. Findings of an association between inflammation within the thyroid gland and prognosis in PTC [10][11][12][13][14] have led to the assumption that dendritic cells might affect PTC prognosis by reinforcing the inflammatory process.…”