The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer

Pavlidis, Efstathios T; Lambropoulou, María; Symeonidis, Nikolaos; Anagnostopoulos, Constantinos; Tsaroucha, Alexandra; Kotini, A; Nikolaidou, Christina; Kiziridou, Anastasia; Simopoulos, Constantinos

doi:10.1080/08941939.2017.1280565

Cited by 2 publications

(2 citation statements)

References 36 publications

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“…All 40 retrospective cohort studies were published between 1997 and 2017. Among the included studies, 7 were of lung cancer (non-small cell lung cancer [NSCLC]: 6 cases, [ 10 , 24 – 28 ] lung cancer: 1 case [ 29 ] ), 4 studies were of breast cancer, [ 30 – 33 ] 6 were of head and neck cancer (nasopharyngeal carcinoma [NPC]: 4 cases, [ 34 – 37 ] tonsil cancer: 1 case, [ 38 ] oral squamous cell carcinomas: 1 case [ 39 ] ), 20 of digestive tract cancers (esophageal squamous cell cancer [ESCC]: 8 cases, [ 40 – 47 ] gastric cancer: 3 cases, [ 9 , 48 , 49 ] colon cancer: 1 case, [ 50 ] colorectal cancer [CRC]: 2 cases, [ 49 , 51 ] hepatocellular carcinoma [HCC]: 4 cases, [ 52 – 55 ] pancreatic carcinoma: 2 cases, [ 56 , 57 ] gallbladder adenocarcinoma: 1 case [ 58 ] ), and 2 of gynecologic cancers (cervical cancer: 1 case, [ 59 ] ovarian carcinoma: 1 case [ 60 ] ).…”

Section: Resultsmentioning

confidence: 99%

Prognostic and clinical significance of metastasis-associated gene 1 overexpression in solid cancers

Fan

2018

Medicine

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Background:In the past 2 decades, metastasis-associated gene 1 (MTA1) has attracted attention for its close association with cancer progression and its roles in chromatin remodeling processes, making it a central gene in cancer. The present meta-analysis was performed to assess MTA1 expression in solid tumors.Materials and methods:This analysis identified studies that evaluated the relationship between MTA1 expression and clinical characteristics or prognosis of patients with solid tumors via the PubMed, Cochrane Library, and Embase electronic databases. Fixed-effect and random-effect meta-analytical techniques were used to correlate MTA1 expression with outcome measures. The outcome variables are shown as odds ratio (OR) or hazard ratio (HR) with 95% confidence interval (CI).Results:Analysis of 40 cohort studies involving 4564 cancer patients revealed a significant association of MTA1 overexpression with tumor patient age (>50 vs. <50 years: combined OR 0.73, 95% CI 0.57–0.94), tumor grade (G3/4 vs. G1/2: combined OR 1.94, 95% CI 1.48–2.53), tumor size (>3 cm vs. <3 cm: combined OR 2.35, 95% CI 1.73–3.19), T stage (T3/4 vs. T1/2: combined OR 2.11, 95% CI 1.74–2.56), lymph node metastasis (yes vs. no: combined OR 2.92, 95% CI 2.26–3.75), distant metastasis (yes vs. no: combined OR 2.26, 95% CI 1.42–3.59), TNM stage (III/IV vs. I/II: combined OR 2.50, 95% CI 1.84–3.38), vascular invasion (yes vs. no: combined OR 2.26, 95% CI 1.92–3.56), and poor overall survival time (HR 1.83; 95% CI: 1.53–2.20; P = .000).Conclusions:Our analyses demonstrate that MTA1 was an effective predictor of a worse prognosis in tumor patients. Moreover, MTA1 may play important role in tumor progression and outcome, and targeting MTA1 may be a new strategy for anti-cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Prognostic and clinical significance of metastasis-associated gene 1 overexpression in solid cancers

Fan

2018

Medicine

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“…Staining was graded as negative (0) when ≤10% of cells were stained, as weak (1) when 10-30% of cells were stained, as moderate (2) when 30-70% of cells were stained, and as strong (3) when >70% cells were stained. Histopathological examination of pancreatic and intestinal tissues was performed on hematoxylin/eosin-stained sections, while the severity of histological lesions was graded according to the following scoring system: 0, no lesions; 1, mild lesions; 2, moderate lesions; 3, severe lesions [57].…”

Section: Histopathological Examination and Immunohistochemical Stainingmentioning

confidence: 99%

Eugenol Reduced ΜPO, CD45 and HMGB1 Expression and Attenuated the Expression of Leukocyte Infiltration Markers in the Intestinal Tissue in Biliopancreatic Duct Ligation-Induced Pancreatitis in Rats

Oikonomou,

Nikolaou,

Papachristou

et al. 2023

Medicina

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Background and Objectives: Inflammation and dysregulation in the intestinal barrier function in acute pancreatitis (AP) trigger pancreatic lesions, systemic inflammatory response, and multiple organ dysfunction. Eugenol, as the main component of clove (Syzygium aromaticum), is known for its antioxidant and anti-inflammatory properties. We studied the potentially beneficial effect of eugenol in a rodent model of biliopancreatic duct ligation-induced AP. Materials and Methods: Rats were randomly divided into three groups: Sham, AP, and AP + eugenol (15 mg/kg/day). Serum TNFα, IL-6, IL-18, and resistin levels, as well as IL-6, TNFα, MPO, HMGB1, and CD45 tissue expression, were determined at various timepoints after the induction of AP. Results: Eugenol attenuated hyperemia and inflammatory cell infiltration in the intestinal mucosal, submucosal, and muscular layers. IL-6 and resistin serum levels were significantly reduced in the AP + eugenol group, while serum TNFα and IL-18 levels remained unaffected overall. TNFα pancreatic and intestinal expression was attenuated by eugenol at 72 h, while IL-6 expression was affected only in the pancreas. MPO, CD45, and HMGB1 intestinal expression was significantly reduced in eugenol-treated rats. Conclusions: Eugenol managed to attenuate the inflammatory response in the intestine in duct ligation-induced AP in rats.

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The Immunohistochemical Expression MTA 1 Protein and its Prognostic Value in Pancreatic Cancer

Abstract: MTA 1 protein may constitute an important prognostic marker in pancreatic cancer and could improve prognosis and treatment.

Cited by 2 publications

References 36 publications

Prognostic and clinical significance of metastasis-associated gene 1 overexpression in solid cancers

Prognostic and clinical significance of metastasis-associated gene 1 overexpression in solid cancers

Eugenol Reduced ΜPO, CD45 and HMGB1 Expression and Attenuated the Expression of Leukocyte Infiltration Markers in the Intestinal Tissue in Biliopancreatic Duct Ligation-Induced Pancreatitis in Rats

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