The immunoglobulins: a review.

Martin, N. H.

doi:10.1136/jcp.22.2.117

Cited by 35 publications

(24 citation statements)

References 53 publications

(24 reference statements)

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“…It is important to note that this mechanism is mediated by the Fc fragment and depends on Fc␥-receptor subtype (Fig. 1) [86]. Accordingly, antibodies can enhance dendritic cell (DC)-mediated antigen presentation to T cells [87]; this mechanism is highly dependent upon Fc␥R type IIIa [88], as it has the highest affinity to IgG1.…”

Section: Spontaneous Autoantibodies Are Able To Drive An Effective Rementioning

confidence: 99%

Autoantibodies against tumor-related antigens: Incidence and biologic significance

Kobold¹,

Lütkens²,

Cao³

et al. 2010

Human Immunology

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Section: Spontaneous Autoantibodies Are Able To Drive An Effective Rementioning

confidence: 99%

Autoantibodies against tumor-related antigens: Incidence and biologic significance

Kobold¹,

Lütkens²,

Cao³

et al. 2010

Human Immunology

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“…Immunoglobulins (Ig) are glycoproteins divided into five physiological classes (IgA, IgD, IgE, IgG, IgM). Even though they all posses the same core structure with two identical heavy and light chains connected with disulfide bonds, they differ in terms of their antigen binding capacity, molar mass, and elimination half‐life . As is generally known, approximately 80 % of serum immunoglobulins are IgG molecules with an elimination half‐life of roughly 20–21 days (except for IgG 3 ).…”

Section: Relevant Properties Of Physiologic Immunoglobulinsmentioning

confidence: 99%

Pharmacokinetic characteristics of therapeutic antibodies

Wohlrab

2015

J Deutsche Derma Gesell

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Summary Because of their high molecular weight and their highly hydrophilic character, therapeutic antibodies behave differently in terms of absorption, distribution and elimination compared to conventional drugs. Also, their pharmacokinetic profile varies significantly among individuals. After subcutaneous administration, antibodies are absorbed via the lymphatic system and become systemically bioavailable with some delay. The physicochemical properties of the molecules hinder their distribution from the bloodstream into the tissue. Elimination occurs by proteolysis in various organs (skin, muscle, liver), but mainly within the reticuloendothelial system. Also relevant is the elimination through target antigens (especially in the case of cell‐bound target antigens) as well as a recycling process through binding to the neonatal Fc receptor that provides protection from lysosomal degradation. Depending on the immunogenicity of the therapeutic antibody and the individual immune response, neutralizing antibodies can develop. Pharmacokinetic conditions can be optimized by coadministration of, for example, methotrexate. Moreover, risk factors for the loss of immunological tolerance, such as on‐demand therapy or elective switching of therapeutic antibodies, should be avoided.

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“…Waldenstrom's macroglobulinemia is established in this case by the com bined anatomic, histologic and clinical findings [14,16,21]. Occasionally, as in this case, the lymphadenopathy seems to be limited to the abdominal cavity [3, 12.…”

Section: Discussionmentioning

confidence: 99%

Waldenström’s Macroglobulinemia, Mesangio-Capillary Glomerulonephritis, Angiitis and Myositis

Lin

Orofino

Sherlock

et al. 1973

Nephron

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This is a case report of Waldenström’s macroglobulinemia associated with mesangio-capillary glomerulonephritis, angiitis and myositis. The renal lesion was a major problem. The confinement of lymphadenopathy to the abdominal cavity with absence of an M component in the serum electrophoretic pattern hindered precise antemortem diagnosis. The accompanying mild increase in serum IgA mimicked Aleutian mink disease. The possibility of dysproteinemia playing a role in the renal alteration is suggested. We believe that the primary disease is dysproteinemia with an immune disturbance in a lymphoproliferative disorder with diversified clinical manifestations.

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The immunoglobulins: a review.

Cited by 35 publications

References 53 publications

Autoantibodies against tumor-related antigens: Incidence and biologic significance

Autoantibodies against tumor-related antigens: Incidence and biologic significance

Pharmacokinetic characteristics of therapeutic antibodies

Waldenström’s Macroglobulinemia, Mesangio-Capillary Glomerulonephritis, Angiitis and Myositis

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