1980
DOI: 10.1016/0092-8674(80)90476-6
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The immunoglobulin μ chains of membrane-bound and secreted IgM molecules differ in their C-terminal segments

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Cited by 150 publications
(53 citation statements)
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“…Many cellular and viral transmembrane proteins, such as the erythrocyte glycophorin (27,231,40), heavy chains of membrane-associated IgM (234,108) and the histocompatibility antigens (249,160), as well as the envelope glycoprotein (G protein) of VSV (106) have their amino-terminal ends exposed on the luminal or extracellular face of membranes and the carboxy-terminal portions on the cytoplasmic side. It may be postulated that all proteins of this transmembrane disposition are synthesized in membrane-bound ribosomes and that their orientation results from cotranslational insertion of the polypeptides into the membrane by a process akin to an interrupted vectorial discharge (Fig; 1).…”
Section: The Disposition Of a Protein In A Membrane As A Results Of Thmentioning
confidence: 99%
See 1 more Smart Citation
“…Many cellular and viral transmembrane proteins, such as the erythrocyte glycophorin (27,231,40), heavy chains of membrane-associated IgM (234,108) and the histocompatibility antigens (249,160), as well as the envelope glycoprotein (G protein) of VSV (106) have their amino-terminal ends exposed on the luminal or extracellular face of membranes and the carboxy-terminal portions on the cytoplasmic side. It may be postulated that all proteins of this transmembrane disposition are synthesized in membrane-bound ribosomes and that their orientation results from cotranslational insertion of the polypeptides into the membrane by a process akin to an interrupted vectorial discharge (Fig; 1).…”
Section: The Disposition Of a Protein In A Membrane As A Results Of Thmentioning
confidence: 99%
“…Recent studies have indicated that membrane-associated and secretory IgM contain 1L-chains that differ in peptide segments located at their extreme carboxy-terminal ends (108,206,234). Comparison of sequences of cDNA clones obtained from the mRNA of a single myeloma tumor revealed the existence of two types of messenger RNA for tL chains, which differed only in nucleotide sequences at their 3'-terminal ends (174) .…”
Section: Halt or Stop Transfer Signalsmentioning
confidence: 99%
“…5). Despite m being 22 residues longer than s (36), the presence of an additional N-glycan in the s carboxyl-terminal tailpiece makes it difficult to distinguish the two chains electrophoretically (Fig. 5A, lane 1).…”
Section: Tcr␣ and Chains Present In Covalent Complexesmentioning
confidence: 99%
“…At least two types of cellular transmembrane surface glycoproteins have very short cytoplasmic domains consisting of three amino acid residues, immunoglobulin ~ and 5 membrane heavy chains (#m, 5m) (11,25). From previous studies it was determined that biosynthesis and maturation of.//m or 5m occurs via a pathway similar to the VSV G protein: from the rough ER through the Golgi complex to the plasma membrane (53, 60).…”
mentioning
confidence: 99%