The immunoglobulin G antibody response to malaria merozoite antigens in asymptomatic children co-infected with malaria and intestinal parasites

Ndiabamoh, Crespo’o Mbe-cho; Ekali, Gabriel Loni; Esemu, Livo F.; Lloyd, Yukie Michelle; Djontu, Jean Claude; Mbacham, Wilfred; Bigoga, Jude D.; Taylor, Diane Wallace; Leke, Rose G. F.

doi:10.1371/journal.pone.0242012

Cited by 2 publications

(1 citation statement)

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“…Older under-five children were more likely to be infected as compared to younger ones [46][47][48]. Passively transferred maternal antibodies, such as lactoferrin and secretory IgA, provide protection to infants against malaria [49,50]. Besides, older children are more exposed to mosquitoes compared to younger ones, being more protected by their parents.…”

Section: Discussionmentioning

confidence: 99%

Pooled prevalence and risk factors of malaria among children aged 6–59 months in 13 sub-Saharan African countries: A multilevel analysis using recent malaria indicator surveys

et al. 2023

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Background Every 75 seconds, a child under five dies of malaria. Mainly children, aged between six months and five years, are at the highest risk for malaria. These children lost maternal immunity and did not yet developed specific immunity to the infection. Under the age of five, children bear the highest burden of malaria in Sub-Saharan Africa (SSA). Many individual and community level factors could contribute to malaria prevalence remaining high among under-five children in the region. Thus, this study aimed to assess the pooled prevalence of malaria among children aged 6–59 months and identify potential factors associated with malaria by using recent Malaria Indicator Surveys in 13 SSA countries. Methods Data for this study were drawn from recent 13 Sub-Saharan African countries Malaria Indicator Surveys (MIS). A total weighted sample of 60,541 children aged 6–59 months was included. STATA version 14.2 was used to clean, code and analyze the data. Multilevel logistic regression was employed to identify factors associated with malaria. Adjusted odds ratio with 95% CI and a P value <0.05 was reported to indicate statistical association. Model fitness and comparison were done using Inter cluster correlation coefficient, Median odds ratio, proportional change in variance, and deviance. Results The pooled prevalence of malaria among children aged 6–59 months was found to be 27.41% (95% CI: 17.94%-36.88%). It ranges from 5.04% in Senegal to 62.57% in Sierra Leone. Aged 36–47 months (AOR = 3.54, 95% CI 3.21–3.91), and 48–59 months (AOR = 4.32, 95% CI 3.91–4.77), mothers attended primary education (AOR = 0.78, 95% CI 0.73–0.84), richer (AOR = 0.35, 95% CI 0.32–0.39), and richest household (AOR = 0.16, 95% CI 0.14–0.19), number of three and more under-five children (AOR = 1.35, 95% CI 1.26–1.45), improved floor material (AOR = 0.65, 95% CI 0.57–0.73), improved wall material (AOR = 0.73, 95% CI 0.64–0.84), improved roof material (AOR = 0.70, 95% CI 0.51–0.93), insecticide-treated bed net (ITN) use (0.56, 95% CI 0.51–0.62), not anemic (AOR = 0.05, 95% CI 0.04–0.06), rural resident (AOR = 2.16, 95% CI 2.06–2.27), high community ITN use (AOR = 0.40, 95% CI 0.24–0.63) and high community poverty (AOR = 2.66, 95% CI 2.53–2.84) were strongly associated with malaria. Conclusions and recommendations Almost 3 out of 10 children were infected by malaria in 13 SSA countries. Malaria infection remains one of the main killers of children aged 6–59 months in the SSA. This study revealed that older under-five children living in large families with low incomes in rural areas are most vulnerable to malaria infection. Our results clearly indicate that ITN utilization and improved housing are promising means to effectively prevent malaria infection among children aged 6–59 months. It is therefore important to note that households with low wealth quintiles and rural residents should be prioritized in any mass distribution of ITNs. This has to be accompanied by education using mass media to enhance community awareness.

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Section: Discussionmentioning

confidence: 99%

Pooled prevalence and risk factors of malaria among children aged 6–59 months in 13 sub-Saharan African countries: A multilevel analysis using recent malaria indicator surveys

et al. 2023

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Role of Infectious Disease at Pivotal Historical Moments

2022

Historical and Epidemiological Analyses on the Impact of Infectious Disease on Society

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This chapter shifts focus away from any kind of totalizing explanation of infectious disease as a whole towards descriptions and discussions of significant historical moments that were shaped by the course of infectious disease. It is perhaps common to discuss human history as the annals of human triumph and tragedies, but, in the same way that it may be impossible to discuss the history of any particular region without at least some implication as to its peripheries, it may be impossible to discuss the Columbian exchange that led to the European colonization of the Americas without reference to the infectious disease that hitched rides westward towards immunologically unprepared lands, depopulating and weakening native civilizations just in time for Europeans to take advantage, to conquer, and to exploit. The infectious component of the Columbian exchange is one of the many macro- and micro-events detailed in this chapter.

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The immunoglobulin G antibody response to malaria merozoite antigens in asymptomatic children co-infected with malaria and intestinal parasites

Cited by 2 publications

References 53 publications

Pooled prevalence and risk factors of malaria among children aged 6–59 months in 13 sub-Saharan African countries: A multilevel analysis using recent malaria indicator surveys

Pooled prevalence and risk factors of malaria among children aged 6–59 months in 13 sub-Saharan African countries: A multilevel analysis using recent malaria indicator surveys

Role of Infectious Disease at Pivotal Historical Moments

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