The immunogenicity and safety of a tetravalent measles-mumps-rubella-varicella vaccine when co-administered with conjugated meningococcal C vaccine to healthy children: A phase IIIb, randomized, multi-center study in Italy

Abstract

NCT01506193.

Seroprevalence and Risk Factors Associated with Measles outbreaks among Children in Kwale, Lamu and Narok Counties in Kenya, 2014

“…These results concur well with other studies done elsewhere which showed the existence of a measles immunity gap between HIV positive and HIV negative children [34,41,42]. Low measles seroprotectivity among HIV sero positive children may be attributed to impaired vaccination response due to compromised immune system at the time of vaccination or accelerated waning of immunity due to impaired immunity [19,34,41,43].…”

Co-administration of vaccines: a focus on tetravalent Measles-Mumps-Rubella-Varicella (MMRV) and meningococcal C conjugate vaccines

“…3 Vaccination strategies adopted in childhood can require a high number of sessions 4 and the fulfillment of the entire vaccination schedule can be challenging for newborns, parents and health professionals. 5 This phenomenon is even more evident with the development and introduction of new vaccines. This makes the vaccination schedule more complex due to the further increase in the number of injections and immunization sessions.…”

“…12,13 Furthermore, co-administration reduces the number of visits and, therefore, decreases stress and discomfort for children and parents. 5 Combined vaccines are thoroughly tested before they are approved for marketing. The United States (US) Food and Drug Administration (FDA) and the European Medicines Agency (EMA) ensure that the new products are safe and effective.…”

“…18,19 Several authors evaluated the safety and immunogenicity of the quadrivalent meningococcal conjugate vaccine (Men ACWY) co-administered with common childhood vaccines, confirming good tolerability, elevated immunogenicity, and safety. [20][21][22][23][24] Finally, with regard to the concomitant administration of meningococcal C conjugated vaccines (as tetravalent or monovalent vaccines) and MMRV, which will be further investigated in the course of this review, in recent studies performed by Durando et al 5 and Klein et al, 2 this co-administration appears to be well tolerated, without safety issues and with a good immune response for both vaccines. 2,5 Public health impact of co-administration Combined and co-administered vaccines optimize vaccination coverage thanks to the simplification of vaccination programs.…”

“…[20][21][22][23][24] Finally, with regard to the concomitant administration of meningococcal C conjugated vaccines (as tetravalent or monovalent vaccines) and MMRV, which will be further investigated in the course of this review, in recent studies performed by Durando et al 5 and Klein et al, 2 this co-administration appears to be well tolerated, without safety issues and with a good immune response for both vaccines. 2,5 Public health impact of co-administration Combined and co-administered vaccines optimize vaccination coverage thanks to the simplification of vaccination programs. 11,25,26 These elements guarantee a significant impact in terms of public health, specifically with the increase in vaccination coverage and the more efficient management of services.…”