The Immunogenicity and Safety of Live Attenuated Varicella-zoster Virus Vaccine in Human Immunodeficiency Virus-infected Children

Abstract

Administration of the 2 doses of varicella vaccine resulted in high seroconversion rates without serious adverse reactions. Varicella vaccination for HIV-infected children should be encouraged.

Update on Opportunistic Infections in the Era of Effective Antiretroviral Therapy

“…93,97,98 The 2014 ACIP Guidelines and the 2013 Infectious Diseases Society of America (IDSA)/HIV Medical Association (HIVMA) Primary Care Guidelines for HIV-infected Patients recommend varicella vaccination in HIV-infected/VZV-seronegative adults with CD4 cell counts >200/mm 3. 89,99 …”

Antibody response to VZV vaccination in HIV infected children

“…The clinical characteristics of the children who did not seroconvert included children with detectable viremia and low CD4% nadir [13]. This might be explained by impaired immune function in HIV-infected children despite receiving antiretroviral therapy.…”

British HIV Association Guidelines on the Use of Vaccines in HIV‐Positive Adults 2015

“…The chickenpox vaccine has been shown to be safe and immunogenic in susceptible children with asymptomatic or mildly symptomatic HIV infection, and a suppressed viral load on ART is associated with improved immunogenicity . Severe, but non‐fatal vaccine‐associated disease has been reported in some children with undiagnosed immunodeficiency .…”