The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens

Webster, Robert G.; Webby, Richard J.; Hoffmann, Erich; Rodenberg, Jeff; Kumar, Mahesh; Chu, Hsien-Jue; Seiler, Patrick; Krauss, Scott; Songserm, Thaweesak

doi:10.1016/j.virol.2006.01.044

Cited by 96 publications

(64 citation statements)

References 26 publications

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“…Through this treatment was observed that infl uenza virus detected in these treated samples demonstrated reduction or total elimination of the viral HA titers (Table 3 and These results are in concordance with the study in ducks developed in Sweden by Wallenstein et al (2006). Webster et al (2006), observed that after birds vaccination against infl uenza HPAI (H 5 N 1 ) that the remained alive were protected against infl uenza.…”

Section: Resultssupporting

confidence: 87%

“…Considering this knowledge of influenza interspecies transmission by ducks, Webster et al(2006), performed an experimental vaccination against HPAI (H 5 N 1 ) intending to immunize these transmitter avians. These authors verifi ed that after the virus challenge performed in these vaccinated ducks, all of them remained alive showing they were protected against the virus.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of compounds from oregano ( Origanum vulgare ) that inactivate the influenza virus in host animals

Mancini¹,

Mendonça²,

Pinto³

et al. 2009

Publ. Exatas

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The infl uenza is a respiratory disease considered as a zoonosis. Its transmisssion between humans and animals can occur through animal contact, manipulation and consumption of food from contamined animals. Avians and swine are responsible by infl uenza contamination in food. The presence of compounds with antioxidant activity in food is related in the inhibition of free-radicals formation and also to inactive viruses. To evaluate the presence of infl uenza virus in animals and the anti-viral action from oregano (Origanum vulgare L.) on the infl uenza virus was also investigated. Samples from 34 swine and 50 ducks were collected. The hemagglutination (HA) and Gold-labeled-optically-read-immunoassay (Gloria) tests were employed for isolation and identifi cation of the infl uenza virus. Antioxidant activity in oregano extract was evaluated by β carotene / linoleic acid system and the total phenolic compounds by Folin-Ciocateau reagent. The antioxidant activity of 100 ppm of phenolic compounds from oregano extract was 89.2% and the association with BHT was observed the increase to 93.6%. Infl uenza positivity was observed in 10% of ducks and 53% of swine, presenting HA 04 HAU/μL and 12 HAU/μL, respectively. These titers decreased after infl uenza virus inactivation by contact for 1 h with 100 ppm (v/v) oregano extract. Therefore, this infl uenza virus could be transmitted by both workers and migratory birds. These data suggest that animals are able to generate infl uenza contamination of food (avian meat, eggs, swine meat) and the phenolic compounds revealed anti-viral action on infl uenza virus. RESUMOA doença respiratória causada pelo vírus infl uenza é considerada uma zoonose. Através do contato entre humanos e animais e, ainda, pelo consumo de alimentos de origem animal contaminados, pode ocorrer a transmissão viral. As aves e os suínos são os mais comuns geradores de alimentos contaminados por infl uenza. Os compostos fenólicos presentes em alimentos possuem ação antioxidante inibidora da formação de radicais livres e inativante viral. Este trabalho avaliou a presença de infl uenza nesses animais e a ação antiviral do orégano (Origanum vulgare L.). Amostras de 34 suínos e 50 patos foram coletadas. O isolamento e identifi cação do vírus infl uenza foram realizados através dos testes de hemaglutinação (HA) e gold-labeled-optically-read-immunoassay (GLORIA). A atividade antioxidante do orégano foi avaliada pelo sistema β-caroteno/ácido linoleico e os teores de fenólicos totais pelo reagente de Folin-Ciocateau. A atividade antioxidante de 100 ppm dos compostos fenólicos extraídos do orégano foi de 89,2% e na associação deste com o BHT foi observado o aumento desta atividade para 93,6%. Os patos (10%) e os suínos (53%) foram positivos aos testes de infl uenza, apresentando, respectivamente, 4 UHA/μL e 12 UHA/μL. Esses títulos de HA foram reduzidos após a inativação do vírus, promovida pelo contato por uma hora com 100 ppm de extrato de orégano. Esses animais são capazes de contaminar o alimento com o vírus...

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Section: Resultssupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Evaluation of compounds from oregano ( Origanum vulgare ) that inactivate the influenza virus in host animals

Mancini¹,

Mendonça²,

Pinto³

et al. 2009

Publ. Exatas

View full text Add to dashboard Cite

show abstract

“…Mass vaccination against HPAI in Egypt was adopted on the basis of the predicted efficacy of H5N1 vaccines in a number of avian species (36)(37)(38)(39)(40) and the recommendation of FAO/OIE to use vaccination as part of a control strategy for HPAI. Furthermore, field trials of oil emulsion-whole-virus H5 vaccines have shown promise in controlling H5N1 influenza outbreaks in Vietnam and the People's Republic of China (41)(42)(43).…”

Section: Vaccinementioning

confidence: 99%

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Kim

Kayali

Walker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and in humans have failed despite increased biosecurity, quarantine, and vaccination at poultry farms. The ongoing circulation of HP H5N1 avian influenza in Egypt has caused >100 human infections and remains an unresolved threat to veterinary and public health. Here, we describe that the failure of commercially available H5 poultry vaccines in Egypt may be caused in part by the passive transfer of maternal H5N1 antibodies to chicks, inhibiting their immune response to vaccination. We propose that the induction of a protective immune response to H5N1 is suppressed for an extended period in young chickens. This issue, among others, must be resolved and additional steps must be taken before the outbreaks in Egypt can be controlled.

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“…Thus, the minimum vaccination coverage needed in the sub-district poultry population would be 21%, 51% and 32%, respectively, and the maximum value (51%) should be used as target to completely bring the epidemic under control. It should be acknowledged that vaccine efficacy is never 100% (van der Goot et al, 2005;Swayne et al, 2006;Webster et al, 2006), so an extra amount of vaccination coverage should always be added, e.g., 10% (van der Goot et al, 2005;Savill et al, 2006;Tiensin et al, 2007). Two issues must be stressed.…”

Section: Discussionmentioning

confidence: 99%

Transmissibility of the highly pathogenic avian influenza virus, subtype H5N1 in domestic poultry: a spatio-temporal estimation at the global scale

et al. 2012

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Abstract. The highly pathogenic avian influenza virus (HPAIV), subtype H5N1 poses a serious threat not only to the poultry industry and wild birds but also to humans. Despite a large number of studies conducted on various aspects of this virus, its transmissibility is still poorly understood. This study quantifies the basic reproductive number (R 0 ) of the global HPAIV H5N1 spread within domestic poultry during December 2003 to December 2009. Three different approaches were applied to estimate R 0 for HPAIV H5N1: (i) epidemic doubling time; (ii) spatial distance-based nearest neighbour; and (iii) spatiotemporal distance-based nearest neighbour. These three approaches represent temporal (tR 0 ), spatial (sR 0 ) and spatio-temporal transmissibility (stR 0 ), respectively. The joint application of these three approaches provides a more complete profile by characterising the transmissibility traits of infectious diseases from different perspectives. Estimates of tR 0 gradually decreased over the six sequential epidemic waves (EWs) examined, suggesting that the implemented control measures were effective in reducing the number of outbreaks. However, sR 0 and stR 0 increased from EW1, peaked in EW3 and then gradually decreased during EW4-EW6, reflecting different aspects of disease transmissibility compared to tR 0 . The application of all three methods in the final EW6 showed R 0 >1, suggesting that the control measures implemented did not completely interrupt the transmission cycle, and hence were insufficient to eliminate HPAIV H5N1. Close monitoring of HPAIV H5N1 outbreaks and enhanced control policies is advised.

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The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens

Cited by 96 publications

References 26 publications

Evaluation of compounds from oregano ( Origanum vulgare ) that inactivate the influenza virus in host animals

Evaluation of compounds from oregano ( Origanum vulgare ) that inactivate the influenza virus in host animals

Puzzling inefficiency of H5N1 influenza vaccines in Egyptian poultry

Transmissibility of the highly pathogenic avian influenza virus, subtype H5N1 in domestic poultry: a spatio-temporal estimation at the global scale

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