The immunogenesis of the multiple sclerosis plaque

Lumsden, C. E.

doi:10.1016/0006-8993(71)90052-7

Cited by 160 publications

(76 citation statements)

References 8 publications

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“…The evidence includes intrathecal Ig synthesis (Kabat and Freedman, 1950), the presence of oligoclonal IgG bands in the CSF (Johnson et al, 1977;Lowenthal et al, 1960), identification of plasma cells and Ig in MS lesions and Ig deposition at the border of actively demyelinating plaques (Esiri, 1977;Lumsden, 1971;Storch et al, 1998;Woyciechowska and Brzosko, 1977). Several studies have sought to identify the antigenic targets of the B cells and antibodies found in CSF and brain plaques in MS, yet no single target has been found which is directly responsible for the development or progression of MS. Several of the targets identified thus far are of interest to our study.…”

Section: Discussionmentioning

confidence: 99%

Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis

Peterson

Tsunoda

Masaki

et al. 2007

Journal of Neuroimmunology

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Two myelin oligodendrocyte glycoprotein ) monoclonal antibodies (mAbs) were produced from an A.SW mouse with progressive experimental autoimmune encephalomyelitis. Polyreactivity/specificity of the mAbs was demonstrated by ELISA. Functionality and a potential role in pathogenesis of systemic autoimmunity were demonstrated in vitro in a lymphocytotoxicity assay and in vivo upon injection into naïve mice. Injection of MOG mAb producing hybridomas into naïve mice resulted in immunoglobulin deposition in kidneys and liver. This model will be useful in determining whether transitional forms between CNS (organ)-specific and systemic autoimmune diseases exist, and whether progressive multiple sclerosis has features of a systemic autoimmune disease.

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Section: Discussionmentioning

confidence: 99%

Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis

Peterson

Tsunoda

Masaki

et al. 2007

Journal of Neuroimmunology

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“…The inflammatory infiltrates are composed of T lymphocytes, some B cells and plasma cells, as well as activated macrophages or microglial cells. IgG and complement are localized primarily at the periphery of plaques (12). Although it is generally believed that inflammation is an obligatory and possibly primary feature of demyelination in MS, myelin destruction may also proceed in a context nearly devoid of lymphocytic infiltration, suggesting a role for endogenous glia (microglia or astrocytes) in mediating injury (13).…”

Section: Antibody In Msmentioning

confidence: 99%

B cells in multiple sclerosis

Mark¹

2004

Front Biosci

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The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands. Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown. Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.

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“…In his seminal description of the pathologic process of multiple sclerosis, Charcot 1 did not describe lesions in the cerebral cortex. The first descriptions by Brownell and Hughes 2 and subsequently by Lumsden 3,4 made the existence of gray matter lesions apparent. Several postmortem pathologic studies have revealed significant involvement of the gray matter.…”

mentioning

confidence: 98%