The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice

Zhang, Jin; He, Shuaibing; Zhang, Xiufang; Ling, Yuhang; Li, Xiaoyü; Zhang, Hui; Hou, Diandong

doi:10.1039/d1fo01257f

Cited by 30 publications

(20 citation statements)

References 40 publications

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“…All results confirmed the potential effects of sour soybean milk with polypeptides from P. eryngii on regulating the microbial community structure and composition, restoring the biological imbalance of intestinal microorganisms in CTX-treated mice. The conclusions were consistent with Ma et al (2021) and Zhang et al (2021) , which have reported that inflammation-related and immunosuppressed disorders could be regulated by keeping the balance of intestinal flora.…”

Section: Discussionsupporting

confidence: 91%

“…It is well known that CTX is averse to the immune system of the organism and leads to immunosuppression ( Zhang et al, 2021 ), thus we have established the immunosuppression mice model induced by CTX to investigate the immunoregulation effects of sour soybean milk fermented with polypeptides from P. eryngii . As the important immune organs, the spleen and thymus indexes could reflect the immune function of the organism.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidant and Immunostimulatory Activities of Fermented Sour Soybean Milk Added With Polypeptides From Pleurotus eryngii

Song

Chen

2022

Front. Microbiol.

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The improved quality of sour soybean milk by adding polypeptide from Pleurotus eryngii was investigated in this study, and the immunomodulatory effect of sour soybean milk fermented with polypeptides from P. eryngii was also evaluated in immunosuppressed mice induced by cyclophosphamide. Results showed the physicochemical property of sour soybean milk fermented with small-molecular-weight polypeptide (<3 kDa) were superior to the others including the decrease of pH, and increase of acidity, water-holding capacity and lactic acid bacteria count. The animal experiment demonstrated that sour soybean milk with polypeptide could effectively reverse the decreasing trend of thymus/spleen index and hematological parameters, enhance murine immune functions including serum hemolysin and splenic lymphocyte proliferation, and inhibit oxidative stress. In addition, sour soybean milk fermented with polypeptide could increase the diversity of intestinal flora, and increase the abundances of Firmicutes, Bacteroides, and Lactobacillus. Taken together, it could provide a theoretical basis for developing an immunomodulatory agent or functional food additives with antioxidant activity.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Antioxidant and Immunostimulatory Activities of Fermented Sour Soybean Milk Added With Polypeptides From Pleurotus eryngii

Song

Chen

2022

Front. Microbiol.

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“…The relative abundance of Anaerotruncus , Lachnospiraceae UCG-001 , [Eubacterium] Coprostanoligenes Group , Ruminococcaceae UCG-005 , Rikenellaceae RC9 gut group , Bifidobacterium , Coriobacteriaceae UCG-002 , Faecalibaculum , and Marvinbryantia were significantly correlated with xanthine oxidase activity in the cerebral cortex. Sea buckthorn pulp oil was shown to have immunoenhancing effects in suppressed mice by cyclophosphamide-induced immunosuppression and increases the abundance of Anaerotruncus [ 28 ]. Glycine was shown to protect against lipopolysaccharide-induced intestinal injury and improve the abundance of Anaerotruncus [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Lactobacillus paracasei CCFM1229 and Lactobacillus rhamnosus CCFM1228 Alleviated Depression- and Anxiety-Related Symptoms of Chronic Stress-Induced Depression in Mice by Regulating Xanthine Oxidase Activity in the Brain

Tian

Zhu

et al. 2022

Nutrients

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Depression is a common mood disorder that affects around 350 million people worldwide. We studied the effect of supplementation with Lactobacillus strains for the treatment of depression. Except for control group (n = 8), C57BL/6J mice were treated with Lactobacillus during six weeks of chronic unpredictable stress (depression group: n = 9, Lactobacillus intervention group: n = 7). L. paracasei CCFM1229 and L. rhamnosus CCFM1228 significantly reduced depressive behaviour in the forced swimming test and tail suspension test, significantly reduced anxiety behaviour in the open field test, and reduced anxiety behaviour in the marble burying test and light/dark box test. L. paracasei CCFM1229 and L. rhamnosus CCFM1228 significantly increased the brain serotonin and brain-derived neurotrophic factor concentrations, and CCFM1229 significantly decreased the serum corticosterone concentration, all of which are closely associated with the relief of depressive symptoms. Furthermore, CCFM1229 and CCFM1228 were shown to regulate purine metabolism in mice, as indicated by decreases in brain xanthine oxidase activity and an increase in liver adenosine deaminase activity. Anxiety- and depression-related indicators were significantly associated with xanthine oxidase activity in the cerebral cortex. The strains CCFM1229 and CCFM1228 reduced anxiety- and depression-related behaviour in a mouse model of chronic stress-induced depression, which may be achieved by regulating the activity of brain xanthine oxidase.

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“…The heat map and LEfSe analysis showed that ABP decreased the relative abundance of some potentially pathogenic bacteria ( g_Streptococcus, g_Proteus, g_Corynebacterium, g_Anaeroplasma, g_Acinetobacter, and g_Ralstonia ) ( Wu et al, 2018 ; Liu et al, 2019 ; Xia X. et al, 2020 ; Zorron Cheng Tao Pu et al, 2020 ; Marongiu et al, 2021 ; Zhang et al, 2021 ). GC-MS results revealed that ABP increased the levels of SCFAs in AOM/DSS induced CAC mice.…”

Section: Discussionmentioning

confidence: 99%

Albuca Bracteata Polysaccharides Attenuate AOM/DSS Induced Colon Tumorigenesis via Regulating Oxidative Stress, Inflammation and Gut Microbiota in Mice

Qin

Liu

et al. 2022

Front. Pharmacol.

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Inflammation is an important risk factor in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Accumulating evidence indicates that some phytochemicals have anti-cancer properties. Polysaccharides extracted from Albuca bracteata (AB) have been reported to possess anti-neoplastic activities on colorectal cancer (CRC) models. However, it is still unclear whether they exert therapeutic effects on colorectal cancer. In this study, we investigate the properties of polysaccharides of A. bracteate, named ABP. The average molecular weight of ABP was 18.3 kDa and ABP consisted of glucose, mannose, galactose, xylose, galacturonic acid, glucuronic acid at a molar ratio of 37.8:8:2.5:1.7:1:1. An Azoxymethane/Dextran sodium sulfate (AOM/DSS) induced CAC mouse model was established. The CAC mice treated with ABP showed smaller tumor size and lower tumor incidence than untreated ones. ABP increased anti-inflammatory cytokine IL-10, inhibited secretion of pro-inflammatory cytokines (IL-6, IFN-γ, and TNF-α), mitigated oxidative stress by increasing GSH and decreasing MDA levels, suppressed the activation of STAT3 and expressions of its related genes c-Myc and cyclin D1. Moreover, ABP treatment increased the relative abundance of beneficial bacteria (f_Ruminococcaceae, g_Roseburia, g_Odoribacter, g_Oscillospira, and g_Akkermansia) and the levels of fecal short-chain fatty acid (SCFA) in CAC model mice. In summary, our data suggest that ABP could be a potential therapeutic agent for treating CAC.

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The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice

Abstract: In this study, the immunomodulatory effect of Seabuckthorn (SBT) pulp oil was elucidated in immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed that SBT pulp oil could reverse...

Cited by 30 publications

References 40 publications

Antioxidant and Immunostimulatory Activities of Fermented Sour Soybean Milk Added With Polypeptides From Pleurotus eryngii

Antioxidant and Immunostimulatory Activities of Fermented Sour Soybean Milk Added With Polypeptides From Pleurotus eryngii

Lactobacillus paracasei CCFM1229 and Lactobacillus rhamnosus CCFM1228 Alleviated Depression- and Anxiety-Related Symptoms of Chronic Stress-Induced Depression in Mice by Regulating Xanthine Oxidase Activity in the Brain

Albuca Bracteata Polysaccharides Attenuate AOM/DSS Induced Colon Tumorigenesis via Regulating Oxidative Stress, Inflammation and Gut Microbiota in Mice

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