1999
DOI: 10.1590/s0104-79301999000100006
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THE IMMUNOCHEMICAL REACTIVITY AND NEUTRALIZING CAPACITY OF POLYVALENT Vipera (EUROPEAN) ANTIVENOM ON ENZYMATIC AND TOXIC ACTIVITIES IN THE VENOMS OF CROTALIDS FROM ARGENTINA

Abstract: The immunochemical reactivity and neutralizing capacity of polyvalent Vipera antivenom (Vipera ammodytes, Vipera aspis, Vipera berus, Vipera lebetina, and Vipera xanthina) were tested on the enzymatic and biological activities of Crotalus durissus terrificus and the following Bothrops venoms from Argentina (Bothrops alternatus, Bothrops ammodytoides, Bothrops neuwiedii, Bothrops jararaca, Bothrops jararacussu, and Bothrops moojeni). The Vipera antivenom reacted weakly when tested by double immunoprecipitation … Show more

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Cited by 8 publications
(3 citation statements)
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“…Improving antiviperinum production by immunizing horses with horned viper toxin is still important because horned viper is the most venomous and most widespread European venomous snake. In addition, V. ammodytes antivenom is cross-reactive with the venom of the common European adder (V. berus), as well as with venoms of other European Viperidae [26,27]. In this paper, we describe a new immunization protocol used for anti-viper antivenom production.…”
Section: Discussionmentioning
confidence: 99%
“…Improving antiviperinum production by immunizing horses with horned viper toxin is still important because horned viper is the most venomous and most widespread European venomous snake. In addition, V. ammodytes antivenom is cross-reactive with the venom of the common European adder (V. berus), as well as with venoms of other European Viperidae [26,27]. In this paper, we describe a new immunization protocol used for anti-viper antivenom production.…”
Section: Discussionmentioning
confidence: 99%
“…One of the most used and aged antivenom potency assessing method is based on the injection in the animal experiment bodies of a significant venom-antivenom mixture and interpolation of the 50% survival animal 1,3,7,8,10,11 . Another way is represented by immunoenzymatic method for the assay of antivenom potency [11][12][13][14] . In these cases, antivenom potency is directly articulated on venom unit quantity but, as it is already well known, even the venom of the same snake species differs (sometime substantially) in theirs biological and toxicological properties.…”
Section: Introductionmentioning
confidence: 99%
“…Because all venoms (particularly harvested from snake) possess a very significant enzymatic content, the antivenom potency can be also determined by antienzymatic assay 1,13,15,16 . The antivenom efficacy values obtained by all previously mentioned methods can be indirectly compared using correlation coefficients 15,16 .…”
Section: Introductionmentioning
confidence: 99%