2009
DOI: 10.1016/j.ijpara.2008.08.002
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The immunobiology of the innate response to Toxoplasma gondii

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Cited by 203 publications
(175 citation statements)
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“…Most humans tend to produce high avidity IgG anti-T. gondii antibodies, since contact with the infecting forms of T. gondii also stimulates the development of immune memory (16)(17)(18)(19)(20)(21). Additionally, older individuals seem to be exposed to a greater number of stimuli as well as reinfections by this parasite, without necessarily manifesting the clinical form of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…Most humans tend to produce high avidity IgG anti-T. gondii antibodies, since contact with the infecting forms of T. gondii also stimulates the development of immune memory (16)(17)(18)(19)(20)(21). Additionally, older individuals seem to be exposed to a greater number of stimuli as well as reinfections by this parasite, without necessarily manifesting the clinical form of the disease.…”
Section: Discussionmentioning
confidence: 99%
“…However, the action of NO is only beneficial to host cells in acute infections stages as 772 its prolonged action is thought to halt replication of tachyzoites, thus promoting their 773 transition to the relatively dormant bradyzoites [129], which seek refuge in cysts, thus 774 promoting a chronic condition [133]. It is thought that the expression of TgHsp70 775 during a primary infection is thought to promote subsequent tolerance to NO [138], 776 thus TgHsp70 is capable of promoting parasite development and pathogenesis.…”
Section: Introduction 713mentioning
confidence: 99%
“…cNK cells may also contribute to the rapid elimination of infected cells by direct cytotoxicity. In the absence of cNK cells, impaired priming of CD4 + and CD8 + T cells was observed [50]. Recently, cNK cells have also been identified as a major source of IL-17 during T. gondii infection, a cytokine that confers resistance to this pathogen [51].…”
Section: Cnk Cellsmentioning
confidence: 99%