The immunoarchitecture of cutaneous pseudolymphoma

Wirt, Daniel P.; Grogan, Thomas M.; Jolley, Carolyn S.; Rangel, Catherine S.; Payne, Claire M.; Hansen, Ronald C.; Lynch, Peter; Schuchardt, Maria

doi:10.1016/s0046-8177(85)80089-7

Cited by 48 publications

(13 citation statements)

References 30 publications

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“…Based on that hypothesis, the number of DC should decrease with malignant evolution. Previously, Wirt et al [19] evaluated LC presence in the epidermis and dermis in cutaneous pseudolymphomas and found it enhanced. Others suggested that the abundance of CD1a + cells might be useful in the differentiation between CTCL and pseudo-CTCL [9].…”

Section: Discussionmentioning

confidence: 99%

Study of the reactive dendritic cells in small B-cell lymphoproliferations of the skin

et al. 2007

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Distinguishing between low-grade primary cutaneous B-cell lymphoma (LG-pCBCL) and cutaneous lymphoid hyperplasia (CLH) based on histological features is often difficult. CLH lesions contain numerous reactive cells of the histiocyte lineage [Langerhans cells (LC), dermal dendritic cells (DDC), and macrophages], which are also often present in CBCL. The aim of this study was to determine whether immunohistochemical detection of those cells could help differentiate between CLH and LG-pCBCL. We determined the percentages of those histiocytic cells in the dermal infiltrates of 45 cases of cutaneous lymphoproliferations comprising 16 CLH and 29 LG-pCBCL (19 follicle-center cell lymphomas and 10 marginal zone lymphomas) by immunohistochemical labeling with antibodies to CD1a, FXIIIa, and CD68 to respectively detect LC, DDC, and macrophages. To avoid observer-dependent bias, an automated morphometric analysis method was used to recognize immunoreactive cells and calculate their percentages within the infiltrate. FXIIIa(+) cells were significatively more frequent in CLH than in LG-pCBCL, whereas CD1a(+) and CD68(+) cell frequencies were comparable in the two groups. The results of our study suggest that DDC might play an important role in the genesis of cutaneous lymphomas.

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Section: Discussionmentioning

confidence: 99%

Study of the reactive dendritic cells in small B-cell lymphoproliferations of the skin

et al. 2007

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“…The follicles are mostly composed of large B cells in the center, with small B lymphocytes in close contact with T CD3 lymphocytes at the periphery, whereas interfollicular zones are mostly composed of T lymphocytes mixed with macrophages. 28,29 Furthermore, the fact that different types of vaccinations, and different lots of the same vaccine, were involved rules out a contamination of vaccines by a common agent. The negativity of patch tests using aluminium hydroxide and/or vaccine in our patients is not surprising, because contact hypersensitivity to aluminium has been scarcely documented in granulomatous delayed lesions occurring in vaccinated patients, and the injection route is likely to be mandatory in these unusual reactions.…”

Section: Discussionmentioning

confidence: 99%

Vaccination-induced cutaneous pseudolymphoma

Maubec

Pinquier

Viguier

et al. 2005

Journal of the American Academy of Dermatology

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“…In case 27 with distinct B-and T-cell compartmentalization, most B-cell nodules lacked a DRC network. This could suggest B-cell autonomy 16 and perhaps a step toward lymphomagenesis. The relative proportion of T and B cells is not a reliable feature.…”

Section: Discussionmentioning

confidence: 99%