The Immune System during Exposure to Extreme Physiologic Conditions

Pedersen, Bente Klarlund; Käppel, M.; Klokker, Mads; Nielsen, Henrik; Secher, N. H.

doi:10.1055/s-2007-1021125

Cited by 88 publications

(56 citation statements)

References 30 publications

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“…18,19 Previous studies showed that prostaglandins from activated monocytes and neutrophils that have migrated into damaged tissue might contribute to the reduction of NKCA. 9,11 In the present study, prostaglandins significantly increased after exercise in SCI subjects but not in able-bodied persons. Since the intensity of exercise in SCI subjects was similar to that of able-bodied subjects, we suggest that arm cranking during ergometer exercise in SCI subjects could result in compression of the tissue in paralyzed trunk, hip and lower limbs and induce distress and/or microdamage in the paralyzed area.…”

Section: Discussioncontrasting

confidence: 46%

“…12,13 NKCA is stimulated by adrenaline, 3 suppressed by cortisol 10 and inhibited by prostaglandins. 9,11 The purpose of this study was to investigate the pattern of NKCA during exercise in SCI persons and to determine the mechanism(s) of any exerciseinduced change in NKCA, including the effects of adrenaline, PGE 2 and cortisol. For this purpose, we examined NKCA response to 2-h arm ergometer exercise at 60% of maximum oxygen consumption (VO 2max ) in SCI and ablebodied persons.…”

Section: Introductionmentioning

confidence: 99%

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Attenuation of natural killer cell activity during 2-h exercise in individuals with spinal cord injuries

Ueta

Furusawa²,

Takahashi

et al. 2007

Spinal Cord

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Design: Non-randomized study. Objective: To determine natural killer cell cytotoxic activity (NKCA) to 2-h arm ergometer exercise in persons with spinal cord injuries (SCI) and the underlying mechanism of such response. Setting: University of Occupational and Environmental Health, Japan. Methods: We examined NKCA response to 2-h arm crank ergometer exercise at 60% of maximum oxygen consumption (VO 2max ) in SCI and able-bodied persons. NKCA and plasma concentrations of prostaglandin E 2 (PGE 2 ), adrenaline and cortisol were measured before, during and immediately after the exercise. The study included seven subjects with SCI between Th11 and L4 and six able-bodied persons.Results: NKCA in able-bodied subjects increased (Po0.05) at 60 min of exercise and immediately after the exercise, and remained elevated up to 2 h after exercise. However, NKCA in SCI decreased (Po0.05) immediately after exercise but recovered at 2 h after exercise. Plasma adrenaline in both groups increased significantly (Po0.05) immediately after exercise and returned to baseline level 2 h after the exercise. Plasma cortisol in both groups remained constant throughout the study. In SCI, PGE 2 significantly increased immediately after 2 h exercise and returned to the baseline level 2 h after exercise; however, it remained unchanged during the test in able-bodied subjects. Conclusion: Our results suggested that increase of PGE 2 in SCI partially contributes to NKCA.

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Section: Discussioncontrasting

confidence: 46%

Section: Introductionmentioning

confidence: 99%

Attenuation of natural killer cell activity during 2-h exercise in individuals with spinal cord injuries

Ueta

Furusawa²,

Takahashi

et al. 2007

Spinal Cord

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“…Estudos demonstraram que este sistema, quando relacionado ao exercício físico como modelo mensurável de indução ao estresse também sofre alterações funcionais consideráveis 6,[8][9][10][11] .…”

Section: Introductionunclassified

“…Além disso, sabe-se que o exercício físico como um dos fatores de indução ao estresse também contribui para que ocorram alterações funcionais neste sistema 6,9,10,11 .…”

Section: Introductionunclassified

Desempenho De Indivíduos Com Dermopigmentação Submetidos À Prática De Exercício Físico

Uzunian

Marquezi

Ugolini

et al. 2016

Rev Bras Med Esporte

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RESUMOIntrodução: A duração e a intensidade dos exercícios provocam diferentes alterações no sistema imunológico, dentre elas a diminuição das respostas imunes, acarretando queda no desempenho físico. Sabe-se também que a dermopigmentação pode colaborar com tais alterações no comportamento deste sistema. Objetivo: Avaliar os efeitos da dermopigmentação sobre o desempenho no exercício físico. Método: Neste ensaio clínico participaram 12 sujeitos, dentre eles seis com dermopigmentação, idade (anos), peso (Kg), estatura (cm) e gordura corporal (%) de 16,5 ± 1,16; 68,10 ± 6,83; 176,29 ± 7,71; 11,49 ± 0,58 respectivamente, divididos em dois grupos, sendo submetidos a teste de esforço máximo com intensidade progressiva em esteira ergométrica para determinação do consumo máximo de oxigênio (VO2 máx ), limiares anaeróbios (LAns) e economia de corrida (EC 14km/h %), sendo realizadas coletas de lactato pré e 5 minutos pós-teste. Os dados foram tratados por "teste t" para variáveis independentes, tendo como nível de significância adotado α < 0,05. Resultados: Foram observadas diferenças significativas entre os grupos em relação à concentração sanguínea de lactato (CSL) pré-teste (4,6 ± 0,11 e 3,23 ± 0,88 para dermopigmentados e não dermopigmentados, respectivamente; p < 0,05) e 5 minutos pós-teste (5,65 ± 0,49 e 13,13 ± 2,20 para dermopigmentados e não dermopigmentados, respectivamente; p < 0,05). O tempo de teste também foi significativamente superior para o grupo não dermopigmentado em comparação ao grupo com dermopigmentação (8 min 47 seg ± 0,08 e 7 min 39 seg ± 0,03 respectivamente; p < 0,05), bem como análise do WURSS-21 (3,33 ± 3,14 e 2,00 ± 1,09, respectivamente; p > 0,05). Em relação às demais variáveis dependentes (VO2 máx , segundo limiar anaeróbio e economia de corrida) não foram encontradas diferenças estatisticamente significativas. Conclusão: A dermopigmentação produziu rendimento inferior no teste de esforço máximo, influenciando o desempenho no exercício físico.Descritores: esforço físico, tatuagem, imunidade. 16.5 ± 1.16; 68.10 ± 6.83; 176.29 ± 7.71; 11.49 ± 0.58, respectively, divided (4.6 ± 0.11 and 3.23 ± 0.88 for the dermal pigmented and non-dermal pigmented groups, respectively; p <0.05) and 5 minutes post-test (5.65 ± 0.49 and 13.13 ± 2.20 ABSTRACT Introduction: Duration and intensity of exercises cause different alterations in the immunity

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“…AT (anaerobic threshold; 무산소성 작업역치)수준을 상위하 는 30분 이상의 운동강도에서는 면역기능은 감소하며 [8], 반면 장·단 시간의 최대하 운동에서는 혈중NK-세포가 증가한다는 보고도 있다 [20]. 관련해서 고지환경에서는 약한 강도의 운동 스트레스가 면역반응을 향상시키고, 장시간 운동스트레스가 강해지면 그 효과가 감소된다고 보고하였으며, 에베레스트 등 반의 검토에서는 높은 극고도에서 T-세포의 활성이 약화된다 고 보고하였다 [19].…”

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The Influences of Immune Function and Respiratory System on Aerobic Exercise by Exposed Acute Hypobaric Hypoxic Environment.

Lee¹

2009

Journal of Life Science

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-The purpose of this study was to investigate the influences of immune function and respiratory system on aerobic exercise of 75 %HRmax intensity in an exposed acute hypobaric hypoxic environment. The subjects were 20 male college students, 10 of which were soccer players (19.6±0.8 yr, BMI 22.3±1.0, VO2max 56.5±4.8 ml/kg/min) and 10 general students (22.2±2.3 yr, BMI 22.7±2.1, VO2max 50.5±6.6 ml/kg/min). Items of measurement after exercise on level and high altitude were O2, CO2, ventilation (VE), respiratory frequency, respiratory quotient, RBC, MCV, MCH, MCHC, Hb, Hct, reticulocyte, WBC, neutrophil, lymphocyte, monocyte, basophil, and immunoglobulin (IgA, IgD, IgG, IgM). As the result of the verifying hypothesis, these results may suggest three new findings: first, to produce hypoxic ventilatory depression not only at level land but also at 3,000 m high altitude during 30 minute aerobics exercise of 75 %HRmax intensity, second to be more excellent for soccer players in adaptation and sensibility on response of respiratory system at high altitude, and third, to change each other by regular exercise habits or altitude in the monocyte. 우리나라 연구진에 의한 고지환경 및 고지시뮬레이션(저 압·저산소환경, 산소분압 조절장치)에서의 적응능력과 관련 된 선행연구는 다수 보고된 바가 있다 [9][10][11]14,15,23,31].구체적으로, 일정기간의 고지 트레이닝의 적응 후 생체적 응 반응으로써는 평지에서의 산소운반 능력 증가(적혈구수 및 헤모글로빈농도의 증가, 근육마이오글로빈 중가, 미토콘 드리아 관련 효소활성도 증가)를 통해 심폐기능의 향상을 가 져오며 [4,5,12,25,17]

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The Immune System during Exposure to Extreme Physiologic Conditions

Cited by 88 publications

References 30 publications

Attenuation of natural killer cell activity during 2-h exercise in individuals with spinal cord injuries

Attenuation of natural killer cell activity during 2-h exercise in individuals with spinal cord injuries

Desempenho De Indivíduos Com Dermopigmentação Submetidos À Prática De Exercício Físico

The Influences of Immune Function and Respiratory System on Aerobic Exercise by Exposed Acute Hypobaric Hypoxic Environment.

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